Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2018.09.007 http://hdl.handle.net/11449/189819 |
Resumo: | The objectives of this study were to evaluate differences between the racing and cutting lines of Quarter Horses in the allele frequencies of polymorphisms identified in the chromosomal region of the myostatin gene (MSTN, ECA18) and to analyze the association of polymorphisms in this chromosomal region with the estimated breeding values (EBVs) for racing performance, given by the maximum speed index, height at withers (HW), thoracic perimeter (TP), and body length (BL) in the racing line, and with EBVs for HW, TP, and BL in the cutting line. Genomic, phenotypic, and pedigree data from 420 horses of both sexes, registered in the Brazilian Association of Quarter Horse breeders, were used (352 of racing line and 68 of cutting line). In the genome region studied (MSTN ± 2 Mb), 46 SNPs and one SINE (ERE1) shared among the cutting and racing lines were identified, and the allele frequencies of 32 SNPs and the one SINE differed significantly between the two lines (P <.05). Furthermore, the part of this region closest to the MSTN (±1 Mb) was found to be less polymorphic in the racing line. Regarding phenotype-associated polymorphisms (unadjusted P <.05), those related to HW in the racing line are highlighted because of their large number and extensive linkage disequilibrium. In addition, these markers exhibited significantly higher frequencies of the favorable allele compared to the cutting line. |
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Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter HorsesERE1HorseMolecular markersQTLSNPSpeedThe objectives of this study were to evaluate differences between the racing and cutting lines of Quarter Horses in the allele frequencies of polymorphisms identified in the chromosomal region of the myostatin gene (MSTN, ECA18) and to analyze the association of polymorphisms in this chromosomal region with the estimated breeding values (EBVs) for racing performance, given by the maximum speed index, height at withers (HW), thoracic perimeter (TP), and body length (BL) in the racing line, and with EBVs for HW, TP, and BL in the cutting line. Genomic, phenotypic, and pedigree data from 420 horses of both sexes, registered in the Brazilian Association of Quarter Horse breeders, were used (352 of racing line and 68 of cutting line). In the genome region studied (MSTN ± 2 Mb), 46 SNPs and one SINE (ERE1) shared among the cutting and racing lines were identified, and the allele frequencies of 32 SNPs and the one SINE differed significantly between the two lines (P <.05). Furthermore, the part of this region closest to the MSTN (±1 Mb) was found to be less polymorphic in the racing line. Regarding phenotype-associated polymorphisms (unadjusted P <.05), those related to HW in the racing line are highlighted because of their large number and extensive linkage disequilibrium. In addition, these markers exhibited significantly higher frequencies of the favorable allele compared to the cutting line.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Animal Science College of Agriculture and Veterinary Science São Paulo State University (UNESP)Department of Animal Breeding and Nutrition College of Veterinary and Animal Science São Paulo State University (UNESP)Department of Animal Science College of Agriculture and Veterinary Science São Paulo State University (UNESP)Department of Animal Breeding and Nutrition College of Veterinary and Animal Science São Paulo State University (UNESP)FAPESP: 2014/20207-1Universidade Estadual Paulista (Unesp)de Matteis, Rafael [UNESP]Pereira, Guilherme L. [UNESP]Casarotto, Letícia T. [UNESP]Tavernaro, Anna Júlia S. [UNESP]Silva, Josineudson Augusto II. V. [UNESP]Chardulo, Luís Artur L. [UNESP]Curi, Rogério A. [UNESP]2019-10-06T16:53:15Z2019-10-06T16:53:15Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-83http://dx.doi.org/10.1016/j.jevs.2018.09.007Journal of Equine Veterinary Science, v. 71, p. 75-83.0737-0806http://hdl.handle.net/11449/18981910.1016/j.jevs.2018.09.0072-s2.0-8505510951535147134139191260000-0001-6289-0406Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-23T14:48:10Zoai:repositorio.unesp.br:11449/189819Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T14:48:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
title |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
spellingShingle |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses de Matteis, Rafael [UNESP] ERE1 Horse Molecular markers QTL SNP Speed |
title_short |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
title_full |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
title_fullStr |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
title_full_unstemmed |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
title_sort |
Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses |
author |
de Matteis, Rafael [UNESP] |
author_facet |
de Matteis, Rafael [UNESP] Pereira, Guilherme L. [UNESP] Casarotto, Letícia T. [UNESP] Tavernaro, Anna Júlia S. [UNESP] Silva, Josineudson Augusto II. V. [UNESP] Chardulo, Luís Artur L. [UNESP] Curi, Rogério A. [UNESP] |
author_role |
author |
author2 |
Pereira, Guilherme L. [UNESP] Casarotto, Letícia T. [UNESP] Tavernaro, Anna Júlia S. [UNESP] Silva, Josineudson Augusto II. V. [UNESP] Chardulo, Luís Artur L. [UNESP] Curi, Rogério A. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Matteis, Rafael [UNESP] Pereira, Guilherme L. [UNESP] Casarotto, Letícia T. [UNESP] Tavernaro, Anna Júlia S. [UNESP] Silva, Josineudson Augusto II. V. [UNESP] Chardulo, Luís Artur L. [UNESP] Curi, Rogério A. [UNESP] |
dc.subject.por.fl_str_mv |
ERE1 Horse Molecular markers QTL SNP Speed |
topic |
ERE1 Horse Molecular markers QTL SNP Speed |
description |
The objectives of this study were to evaluate differences between the racing and cutting lines of Quarter Horses in the allele frequencies of polymorphisms identified in the chromosomal region of the myostatin gene (MSTN, ECA18) and to analyze the association of polymorphisms in this chromosomal region with the estimated breeding values (EBVs) for racing performance, given by the maximum speed index, height at withers (HW), thoracic perimeter (TP), and body length (BL) in the racing line, and with EBVs for HW, TP, and BL in the cutting line. Genomic, phenotypic, and pedigree data from 420 horses of both sexes, registered in the Brazilian Association of Quarter Horse breeders, were used (352 of racing line and 68 of cutting line). In the genome region studied (MSTN ± 2 Mb), 46 SNPs and one SINE (ERE1) shared among the cutting and racing lines were identified, and the allele frequencies of 32 SNPs and the one SINE differed significantly between the two lines (P <.05). Furthermore, the part of this region closest to the MSTN (±1 Mb) was found to be less polymorphic in the racing line. Regarding phenotype-associated polymorphisms (unadjusted P <.05), those related to HW in the racing line are highlighted because of their large number and extensive linkage disequilibrium. In addition, these markers exhibited significantly higher frequencies of the favorable allele compared to the cutting line. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2019-10-06T16:53:15Z 2019-10-06T16:53:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2018.09.007 Journal of Equine Veterinary Science, v. 71, p. 75-83. 0737-0806 http://hdl.handle.net/11449/189819 10.1016/j.jevs.2018.09.007 2-s2.0-85055109515 3514713413919126 0000-0001-6289-0406 |
url |
http://dx.doi.org/10.1016/j.jevs.2018.09.007 http://hdl.handle.net/11449/189819 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 71, p. 75-83. 0737-0806 10.1016/j.jevs.2018.09.007 2-s2.0-85055109515 3514713413919126 0000-0001-6289-0406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
75-83 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792961991379255296 |