Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study

Detalhes bibliográficos
Autor(a) principal: Filho, Pedro Tadao Hamamoto [UNESP]
Data de Publicação: 2015
Outros Autores: Zanini, Marco Antônio [UNESP], Botta, Fabio Pires [UNESP], Rodrigues, Marianna Vaz [UNESP], Bazan, Rodrigo [UNESP], Vulcano, Luiz Carlos [UNESP], Biondi, Germano Francisco [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0102-865020150120000005
http://hdl.handle.net/11449/172429
Resumo: PURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course.
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spelling Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot studyCerebrospinal fluidHydrocephalusMagnetic resonance imagingNeurocysticercosisRatsPURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course.Botucatu Medical School Universidade Estadual Paulista (UNESP)Department of Neurology Psychology and Psychiatry Botucatu Medical School UNESPBotucatu Medical School UNESPDepartment of Microbiology and Immunology Institute of Biosciences UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPDepartment of Veterinary Hygiene ad Public Health School of Veterinary Medicine and Animal Science UNESPBotucatu Medical School Universidade Estadual Paulista (UNESP)Department of Neurology Psychology and Psychiatry Botucatu Medical School UNESPBotucatu Medical School UNESPDepartment of Microbiology and Immunology Institute of Biosciences UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPDepartment of Veterinary Hygiene ad Public Health School of Veterinary Medicine and Animal Science UNESPUniversidade Estadual Paulista (Unesp)Filho, Pedro Tadao Hamamoto [UNESP]Zanini, Marco Antônio [UNESP]Botta, Fabio Pires [UNESP]Rodrigues, Marianna Vaz [UNESP]Bazan, Rodrigo [UNESP]Vulcano, Luiz Carlos [UNESP]Biondi, Germano Francisco [UNESP]2018-12-11T17:00:15Z2018-12-11T17:00:15Z2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article819-823application/pdfhttp://dx.doi.org/10.1590/S0102-865020150120000005Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015.1678-26740102-8650http://hdl.handle.net/11449/17242910.1590/S0102-865020150120000005S0102-865020150012008192-s2.0-84954450185S0102-86502015001200819.pdf4065105014625753Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0,395info:eu-repo/semantics/openAccess2024-09-09T14:06:17Zoai:repositorio.unesp.br:11449/172429Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
title Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
spellingShingle Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
Filho, Pedro Tadao Hamamoto [UNESP]
Cerebrospinal fluid
Hydrocephalus
Magnetic resonance imaging
Neurocysticercosis
Rats
title_short Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
title_full Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
title_fullStr Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
title_full_unstemmed Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
title_sort Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
author Filho, Pedro Tadao Hamamoto [UNESP]
author_facet Filho, Pedro Tadao Hamamoto [UNESP]
Zanini, Marco Antônio [UNESP]
Botta, Fabio Pires [UNESP]
Rodrigues, Marianna Vaz [UNESP]
Bazan, Rodrigo [UNESP]
Vulcano, Luiz Carlos [UNESP]
Biondi, Germano Francisco [UNESP]
author_role author
author2 Zanini, Marco Antônio [UNESP]
Botta, Fabio Pires [UNESP]
Rodrigues, Marianna Vaz [UNESP]
Bazan, Rodrigo [UNESP]
Vulcano, Luiz Carlos [UNESP]
Biondi, Germano Francisco [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Filho, Pedro Tadao Hamamoto [UNESP]
Zanini, Marco Antônio [UNESP]
Botta, Fabio Pires [UNESP]
Rodrigues, Marianna Vaz [UNESP]
Bazan, Rodrigo [UNESP]
Vulcano, Luiz Carlos [UNESP]
Biondi, Germano Francisco [UNESP]
dc.subject.por.fl_str_mv Cerebrospinal fluid
Hydrocephalus
Magnetic resonance imaging
Neurocysticercosis
Rats
topic Cerebrospinal fluid
Hydrocephalus
Magnetic resonance imaging
Neurocysticercosis
Rats
description PURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
2018-12-11T17:00:15Z
2018-12-11T17:00:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-865020150120000005
Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015.
1678-2674
0102-8650
http://hdl.handle.net/11449/172429
10.1590/S0102-865020150120000005
S0102-86502015001200819
2-s2.0-84954450185
S0102-86502015001200819.pdf
4065105014625753
url http://dx.doi.org/10.1590/S0102-865020150120000005
http://hdl.handle.net/11449/172429
identifier_str_mv Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015.
1678-2674
0102-8650
10.1590/S0102-865020150120000005
S0102-86502015001200819
2-s2.0-84954450185
S0102-86502015001200819.pdf
4065105014625753
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 819-823
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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