Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-865020150120000005 http://hdl.handle.net/11449/172429 |
Resumo: | PURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course. |
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Repositório Institucional da UNESP |
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Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot studyCerebrospinal fluidHydrocephalusMagnetic resonance imagingNeurocysticercosisRatsPURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course.Botucatu Medical School Universidade Estadual Paulista (UNESP)Department of Neurology Psychology and Psychiatry Botucatu Medical School UNESPBotucatu Medical School UNESPDepartment of Microbiology and Immunology Institute of Biosciences UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPDepartment of Veterinary Hygiene ad Public Health School of Veterinary Medicine and Animal Science UNESPBotucatu Medical School Universidade Estadual Paulista (UNESP)Department of Neurology Psychology and Psychiatry Botucatu Medical School UNESPBotucatu Medical School UNESPDepartment of Microbiology and Immunology Institute of Biosciences UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science UNESPDepartment of Veterinary Hygiene ad Public Health School of Veterinary Medicine and Animal Science UNESPUniversidade Estadual Paulista (Unesp)Filho, Pedro Tadao Hamamoto [UNESP]Zanini, Marco Antônio [UNESP]Botta, Fabio Pires [UNESP]Rodrigues, Marianna Vaz [UNESP]Bazan, Rodrigo [UNESP]Vulcano, Luiz Carlos [UNESP]Biondi, Germano Francisco [UNESP]2018-12-11T17:00:15Z2018-12-11T17:00:15Z2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article819-823application/pdfhttp://dx.doi.org/10.1590/S0102-865020150120000005Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015.1678-26740102-8650http://hdl.handle.net/11449/17242910.1590/S0102-865020150120000005S0102-865020150012008192-s2.0-84954450185S0102-86502015001200819.pdf4065105014625753Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0,395info:eu-repo/semantics/openAccess2024-09-09T14:06:17Zoai:repositorio.unesp.br:11449/172429Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
title |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
spellingShingle |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study Filho, Pedro Tadao Hamamoto [UNESP] Cerebrospinal fluid Hydrocephalus Magnetic resonance imaging Neurocysticercosis Rats |
title_short |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
title_full |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
title_fullStr |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
title_full_unstemmed |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
title_sort |
Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study |
author |
Filho, Pedro Tadao Hamamoto [UNESP] |
author_facet |
Filho, Pedro Tadao Hamamoto [UNESP] Zanini, Marco Antônio [UNESP] Botta, Fabio Pires [UNESP] Rodrigues, Marianna Vaz [UNESP] Bazan, Rodrigo [UNESP] Vulcano, Luiz Carlos [UNESP] Biondi, Germano Francisco [UNESP] |
author_role |
author |
author2 |
Zanini, Marco Antônio [UNESP] Botta, Fabio Pires [UNESP] Rodrigues, Marianna Vaz [UNESP] Bazan, Rodrigo [UNESP] Vulcano, Luiz Carlos [UNESP] Biondi, Germano Francisco [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Filho, Pedro Tadao Hamamoto [UNESP] Zanini, Marco Antônio [UNESP] Botta, Fabio Pires [UNESP] Rodrigues, Marianna Vaz [UNESP] Bazan, Rodrigo [UNESP] Vulcano, Luiz Carlos [UNESP] Biondi, Germano Francisco [UNESP] |
dc.subject.por.fl_str_mv |
Cerebrospinal fluid Hydrocephalus Magnetic resonance imaging Neurocysticercosis Rats |
topic |
Cerebrospinal fluid Hydrocephalus Magnetic resonance imaging Neurocysticercosis Rats |
description |
PURPOSE: To develop an experimental model of neurocysticercosis-induced hydrocephalus METHODS: There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0.1ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement. RESULTS: Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance. CONCLUSION: The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 2018-12-11T17:00:15Z 2018-12-11T17:00:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-865020150120000005 Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015. 1678-2674 0102-8650 http://hdl.handle.net/11449/172429 10.1590/S0102-865020150120000005 S0102-86502015001200819 2-s2.0-84954450185 S0102-86502015001200819.pdf 4065105014625753 |
url |
http://dx.doi.org/10.1590/S0102-865020150120000005 http://hdl.handle.net/11449/172429 |
identifier_str_mv |
Acta Cirurgica Brasileira, v. 30, n. 12, p. 819-823, 2015. 1678-2674 0102-8650 10.1590/S0102-865020150120000005 S0102-86502015001200819 2-s2.0-84954450185 S0102-86502015001200819.pdf 4065105014625753 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira 0,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
819-823 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546617937068032 |