Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration
Autor(a) principal: | |
---|---|
Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1117/12.548647 http://hdl.handle.net/11449/33709 |
Resumo: | In this paper a piezoelectric composite membranes were developed for charge generator to promoter bone regeneration on defects sites. Is known that the osteogenesis process is induced by interactions between biological mechanisms and electrical phenomena. The membranes were prepared by mixing Barium Titanate (BT) powders and PVDF-TrFE (PVDF:TrFE = 60:40 mol%) on dimethylformamide medium. This precursor solution was dried and crystallized at 100degreesC for 12 hours. Composites membranes were obtained by following methods: solvent casting (SC), spincoating (SP), solvent extraction by water addition (WS) and hot pressing (HP).The microstructural analysis performed by SEM showed connectivity type 3-0 and 3-1 with high homogeneity for samples of ceramic volume fraction major than 0.50. Powder agglomerates within the polymer matrix was evidenced were observed for composites with the BT volume fraction major than 40%. The composite of ceramic fraction of 0.55 presented the best values of remanent polarization (similar to33 muC/cm(2)), but the flexibility of these composites with the larger ceramic fraction was significantly affected.For in vivo evaluation PVDF-TrFE/BT 90/10 membranes with 3cm larger were longitudinally implanted under tibiae of male rabbit. After 21 days the animals were sacrificed. By histological analyses were observed neo formed bone with a high mitotic activity. In the interface bone-membrane was evidenced a pronounced callus formation. These results encourage further applications of these membranes in bone-repair process. |
id |
UNSP_62c360df5270476694d1f7276bead5dd |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/33709 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regenerationcopolymer (PVDF-TrFE)bio-active membranebone promoterbarium titanateferroelectric compositesIn this paper a piezoelectric composite membranes were developed for charge generator to promoter bone regeneration on defects sites. Is known that the osteogenesis process is induced by interactions between biological mechanisms and electrical phenomena. The membranes were prepared by mixing Barium Titanate (BT) powders and PVDF-TrFE (PVDF:TrFE = 60:40 mol%) on dimethylformamide medium. This precursor solution was dried and crystallized at 100degreesC for 12 hours. Composites membranes were obtained by following methods: solvent casting (SC), spincoating (SP), solvent extraction by water addition (WS) and hot pressing (HP).The microstructural analysis performed by SEM showed connectivity type 3-0 and 3-1 with high homogeneity for samples of ceramic volume fraction major than 0.50. Powder agglomerates within the polymer matrix was evidenced were observed for composites with the BT volume fraction major than 40%. The composite of ceramic fraction of 0.55 presented the best values of remanent polarization (similar to33 muC/cm(2)), but the flexibility of these composites with the larger ceramic fraction was significantly affected.For in vivo evaluation PVDF-TrFE/BT 90/10 membranes with 3cm larger were longitudinally implanted under tibiae of male rabbit. After 21 days the animals were sacrificed. By histological analyses were observed neo formed bone with a high mitotic activity. In the interface bone-membrane was evidenced a pronounced callus formation. These results encourage further applications of these membranes in bone-repair process.UNESP, Chem Inst, BR-1480090 Araraquara, SP, BrazilUNESP, Chem Inst, BR-1480090 Araraquara, SP, BrazilSpie - Int Soc Optical EngineeringUniversidade Estadual Paulista (Unesp)Gimenes, R.Zaghete, M. A.Bertolini, M.Varela, José Arana [UNESP]Coelho, L. O.Silva, N. F.2014-05-20T15:22:47Z2014-05-20T15:22:47Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject539-547http://dx.doi.org/10.1117/12.548647Smart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad). Bellingham: Spie-int Soc Optical Engineering, v. 5385, p. 539-547, 2004.0277-786Xhttp://hdl.handle.net/11449/3370910.1117/12.548647WOS:000223368700063Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSmart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad)info:eu-repo/semantics/openAccess2021-10-23T21:41:25Zoai:repositorio.unesp.br:11449/33709Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T21:41:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
title |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
spellingShingle |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration Gimenes, R. copolymer (PVDF-TrFE) bio-active membrane bone promoter barium titanate ferroelectric composites |
title_short |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
title_full |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
title_fullStr |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
title_full_unstemmed |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
title_sort |
Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration |
author |
Gimenes, R. |
author_facet |
Gimenes, R. Zaghete, M. A. Bertolini, M. Varela, José Arana [UNESP] Coelho, L. O. Silva, N. F. |
author_role |
author |
author2 |
Zaghete, M. A. Bertolini, M. Varela, José Arana [UNESP] Coelho, L. O. Silva, N. F. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gimenes, R. Zaghete, M. A. Bertolini, M. Varela, José Arana [UNESP] Coelho, L. O. Silva, N. F. |
dc.subject.por.fl_str_mv |
copolymer (PVDF-TrFE) bio-active membrane bone promoter barium titanate ferroelectric composites |
topic |
copolymer (PVDF-TrFE) bio-active membrane bone promoter barium titanate ferroelectric composites |
description |
In this paper a piezoelectric composite membranes were developed for charge generator to promoter bone regeneration on defects sites. Is known that the osteogenesis process is induced by interactions between biological mechanisms and electrical phenomena. The membranes were prepared by mixing Barium Titanate (BT) powders and PVDF-TrFE (PVDF:TrFE = 60:40 mol%) on dimethylformamide medium. This precursor solution was dried and crystallized at 100degreesC for 12 hours. Composites membranes were obtained by following methods: solvent casting (SC), spincoating (SP), solvent extraction by water addition (WS) and hot pressing (HP).The microstructural analysis performed by SEM showed connectivity type 3-0 and 3-1 with high homogeneity for samples of ceramic volume fraction major than 0.50. Powder agglomerates within the polymer matrix was evidenced were observed for composites with the BT volume fraction major than 40%. The composite of ceramic fraction of 0.55 presented the best values of remanent polarization (similar to33 muC/cm(2)), but the flexibility of these composites with the larger ceramic fraction was significantly affected.For in vivo evaluation PVDF-TrFE/BT 90/10 membranes with 3cm larger were longitudinally implanted under tibiae of male rabbit. After 21 days the animals were sacrificed. By histological analyses were observed neo formed bone with a high mitotic activity. In the interface bone-membrane was evidenced a pronounced callus formation. These results encourage further applications of these membranes in bone-repair process. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-01-01 2014-05-20T15:22:47Z 2014-05-20T15:22:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1117/12.548647 Smart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad). Bellingham: Spie-int Soc Optical Engineering, v. 5385, p. 539-547, 2004. 0277-786X http://hdl.handle.net/11449/33709 10.1117/12.548647 WOS:000223368700063 |
url |
http://dx.doi.org/10.1117/12.548647 http://hdl.handle.net/11449/33709 |
identifier_str_mv |
Smart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad). Bellingham: Spie-int Soc Optical Engineering, v. 5385, p. 539-547, 2004. 0277-786X 10.1117/12.548647 WOS:000223368700063 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Smart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad) |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
539-547 |
dc.publisher.none.fl_str_mv |
Spie - Int Soc Optical Engineering |
publisher.none.fl_str_mv |
Spie - Int Soc Optical Engineering |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964783575826432 |