Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.colsurfb.2016.07.061 http://hdl.handle.net/11449/231382 |
Resumo: | There are requirements for surfaces with antibacterial properties in various technological fields. U-PEO hybrids with antibacterial properties were synthesized by the sol-gel process, incorporating combinations of cerium and silver salts at different silver molar fractions (0, 0.02, 0.05, 0.10, and 1) relative to the total amount of doped cations. The loaded hybrids were characterized by TGA, XRD, and Raman spectroscopy. Release tests were performed using UV–vis spectroscopy, and the antibacterial properties of the hybrids were studied in agar tests and turbidimetry assays. The nanostructural evolution of the hybrids during the release of the antibacterial agents was investigated by in situ SAXS. XRD results showed the presence of the AgCl crystalline phase in the loaded hybrids from a silver molar fraction of 0.05. Raman spectroscopy evidenced the interaction of silver cations with the polymeric part of the hybrid. SAXS results confirmed these interactions and showed that cerium species interacted with both organic and inorganic parts of the hybrids. The loaded U-PEO hybrids were found to release all the incorporated cerium in 1 h, while the hybrid containing 100% of silver released only 78% of the incorporated silver. All the loaded hybrids displayed antibacterial activity against the Pseudomonas aeruginosa bacterium. The antibacterial activity was found to increase with silver molar fraction. Due to its high antibacterial activity and low silver molar fraction, the loaded hybrid with silver molar fraction of 0.10 seemed to be a good compromise between efficiency, esthetic transparency, and photostability. |
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Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activityAntibacterial release agentCeriumOrganic-inorganic hybridsSilverSol-gel processThere are requirements for surfaces with antibacterial properties in various technological fields. U-PEO hybrids with antibacterial properties were synthesized by the sol-gel process, incorporating combinations of cerium and silver salts at different silver molar fractions (0, 0.02, 0.05, 0.10, and 1) relative to the total amount of doped cations. The loaded hybrids were characterized by TGA, XRD, and Raman spectroscopy. Release tests were performed using UV–vis spectroscopy, and the antibacterial properties of the hybrids were studied in agar tests and turbidimetry assays. The nanostructural evolution of the hybrids during the release of the antibacterial agents was investigated by in situ SAXS. XRD results showed the presence of the AgCl crystalline phase in the loaded hybrids from a silver molar fraction of 0.05. Raman spectroscopy evidenced the interaction of silver cations with the polymeric part of the hybrid. SAXS results confirmed these interactions and showed that cerium species interacted with both organic and inorganic parts of the hybrids. The loaded U-PEO hybrids were found to release all the incorporated cerium in 1 h, while the hybrid containing 100% of silver released only 78% of the incorporated silver. All the loaded hybrids displayed antibacterial activity against the Pseudomonas aeruginosa bacterium. The antibacterial activity was found to increase with silver molar fraction. Due to its high antibacterial activity and low silver molar fraction, the loaded hybrid with silver molar fraction of 0.10 seemed to be a good compromise between efficiency, esthetic transparency, and photostability.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry Physico-Chemistry Department University of São Paulo State, Rua Prof. Francisco Degni no 55, PO Box 335, QuitandinhaSchool of Pharmaceutical Sciences Department of Drugs and Medicines University of São Paulo State, Rodovia Araraquara, Jaú km 1CNPq: 150170/2014-9Universidade de São Paulo (USP)Truffault, LaurianneRodrigues, Danilo FernandoSalgado, Hérida Regida NunesSantilli, Celso ValentimPulcinelli, Sandra Helena2022-04-29T08:45:01Z2022-04-29T08:45:01Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article151-160http://dx.doi.org/10.1016/j.colsurfb.2016.07.061Colloids and Surfaces B: Biointerfaces, v. 147, p. 151-160.1873-43670927-7765http://hdl.handle.net/11449/23138210.1016/j.colsurfb.2016.07.0612-s2.0-84982860522Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids and Surfaces B: Biointerfacesinfo:eu-repo/semantics/openAccess2022-04-29T08:45:01Zoai:repositorio.unesp.br:11449/231382Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:45:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
title |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
spellingShingle |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity Truffault, Laurianne Antibacterial release agent Cerium Organic-inorganic hybrids Silver Sol-gel process |
title_short |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
title_full |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
title_fullStr |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
title_full_unstemmed |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
title_sort |
Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity |
author |
Truffault, Laurianne |
author_facet |
Truffault, Laurianne Rodrigues, Danilo Fernando Salgado, Hérida Regida Nunes Santilli, Celso Valentim Pulcinelli, Sandra Helena |
author_role |
author |
author2 |
Rodrigues, Danilo Fernando Salgado, Hérida Regida Nunes Santilli, Celso Valentim Pulcinelli, Sandra Helena |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Truffault, Laurianne Rodrigues, Danilo Fernando Salgado, Hérida Regida Nunes Santilli, Celso Valentim Pulcinelli, Sandra Helena |
dc.subject.por.fl_str_mv |
Antibacterial release agent Cerium Organic-inorganic hybrids Silver Sol-gel process |
topic |
Antibacterial release agent Cerium Organic-inorganic hybrids Silver Sol-gel process |
description |
There are requirements for surfaces with antibacterial properties in various technological fields. U-PEO hybrids with antibacterial properties were synthesized by the sol-gel process, incorporating combinations of cerium and silver salts at different silver molar fractions (0, 0.02, 0.05, 0.10, and 1) relative to the total amount of doped cations. The loaded hybrids were characterized by TGA, XRD, and Raman spectroscopy. Release tests were performed using UV–vis spectroscopy, and the antibacterial properties of the hybrids were studied in agar tests and turbidimetry assays. The nanostructural evolution of the hybrids during the release of the antibacterial agents was investigated by in situ SAXS. XRD results showed the presence of the AgCl crystalline phase in the loaded hybrids from a silver molar fraction of 0.05. Raman spectroscopy evidenced the interaction of silver cations with the polymeric part of the hybrid. SAXS results confirmed these interactions and showed that cerium species interacted with both organic and inorganic parts of the hybrids. The loaded U-PEO hybrids were found to release all the incorporated cerium in 1 h, while the hybrid containing 100% of silver released only 78% of the incorporated silver. All the loaded hybrids displayed antibacterial activity against the Pseudomonas aeruginosa bacterium. The antibacterial activity was found to increase with silver molar fraction. Due to its high antibacterial activity and low silver molar fraction, the loaded hybrid with silver molar fraction of 0.10 seemed to be a good compromise between efficiency, esthetic transparency, and photostability. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2022-04-29T08:45:01Z 2022-04-29T08:45:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.colsurfb.2016.07.061 Colloids and Surfaces B: Biointerfaces, v. 147, p. 151-160. 1873-4367 0927-7765 http://hdl.handle.net/11449/231382 10.1016/j.colsurfb.2016.07.061 2-s2.0-84982860522 |
url |
http://dx.doi.org/10.1016/j.colsurfb.2016.07.061 http://hdl.handle.net/11449/231382 |
identifier_str_mv |
Colloids and Surfaces B: Biointerfaces, v. 147, p. 151-160. 1873-4367 0927-7765 10.1016/j.colsurfb.2016.07.061 2-s2.0-84982860522 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Colloids and Surfaces B: Biointerfaces |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
151-160 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965744753016832 |