Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00580-015-2157-1 http://hdl.handle.net/11449/177484 |
Resumo: | Ehrlichia canis and Hepatozoon canis have been reported infecting a variety of Carnivora species worldwide, including domestic dogs and wild canids. Since both diseases can follow their course while the infected animals remain asymptomatic, assessments of different parameters that may help toward reaching a more accurate diagnosis are welcome. In this regard, the aim of the present study was to assess the activity of adenosine deaminase (ADA) in serum from naturally infected dogs. Forty-nine samples from dogs were used in our study: 15 positive for E. canis (8 asymptomatic and 7 symptomatic animals); 8 positive for H. canis; 14 with mixed infection; and 12 uninfected (used with control). Our results showed that the ADA activity was lower (P < 0.001) in serum from dogs with both infections singly and with mixed infection, in comparison with the uninfected animals (P < 0.001). The symptomatic dogs for E. canis had lower ADA activity when compared with asymptomatic dogs by H. canis (P < 0.01). Therefore, ADA activity reduces in positive dogs for E. canis and H. canis, which can be related to an inflammatory response against infection. |
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Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canisADACanidsE. canisH. canisEhrlichia canis and Hepatozoon canis have been reported infecting a variety of Carnivora species worldwide, including domestic dogs and wild canids. Since both diseases can follow their course while the infected animals remain asymptomatic, assessments of different parameters that may help toward reaching a more accurate diagnosis are welcome. In this regard, the aim of the present study was to assess the activity of adenosine deaminase (ADA) in serum from naturally infected dogs. Forty-nine samples from dogs were used in our study: 15 positive for E. canis (8 asymptomatic and 7 symptomatic animals); 8 positive for H. canis; 14 with mixed infection; and 12 uninfected (used with control). Our results showed that the ADA activity was lower (P < 0.001) in serum from dogs with both infections singly and with mixed infection, in comparison with the uninfected animals (P < 0.001). The symptomatic dogs for E. canis had lower ADA activity when compared with asymptomatic dogs by H. canis (P < 0.01). Therefore, ADA activity reduces in positive dogs for E. canis and H. canis, which can be related to an inflammatory response against infection.Department of Biochemistry and Molecular Biology Universidade Federal de Santa MariaDepartment of Animal Health Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de ColombiaFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista (Unesp)Department of Microbiology and Parasitology Universidade Federal de Santa MariaDepartment of Animal Science Universidade do Estado de Santa Catarina (UDESC)Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista (Unesp)Universidade Federal de Santa MariaUniversidad Nacional de ColombiaUniversidade Estadual Paulista (Unesp)Universidade do Estado de Santa Catarina (UDESC)Bottari, Nathieli B.Vargas-Hernández, Giovanni [UNESP]Tonin, Alexandre A.Pelinson, Luana P.Schetinger, Maria R. C.Morsch, Vera M.André, Marcos R. [UNESP]Machado, Rosangela Z. [UNESP]Tinucci-Costa, Mirela [UNESP]Da Silva, Aleksandro S.2018-12-11T17:25:42Z2018-12-11T17:25:42Z2015-09-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1289-1292application/pdfhttp://dx.doi.org/10.1007/s00580-015-2157-1Comparative Clinical Pathology, v. 24, n. 5, p. 1289-1292, 2015.1618-565X1618-5641http://hdl.handle.net/11449/17748410.1007/s00580-015-2157-12-s2.0-849413167892-s2.0-84941316789.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComparative Clinical Pathology0,224info:eu-repo/semantics/openAccess2023-11-12T06:11:15Zoai:repositorio.unesp.br:11449/177484Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-12T06:11:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
title |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
spellingShingle |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis Bottari, Nathieli B. ADA Canids E. canis H. canis |
title_short |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
title_full |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
title_fullStr |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
title_full_unstemmed |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
title_sort |
Effects of reduction of adenosine deaminase activity in the serum of dogs naturally infected by Ehrlichia canis and Hepatozoon canis |
author |
Bottari, Nathieli B. |
author_facet |
Bottari, Nathieli B. Vargas-Hernández, Giovanni [UNESP] Tonin, Alexandre A. Pelinson, Luana P. Schetinger, Maria R. C. Morsch, Vera M. André, Marcos R. [UNESP] Machado, Rosangela Z. [UNESP] Tinucci-Costa, Mirela [UNESP] Da Silva, Aleksandro S. |
author_role |
author |
author2 |
Vargas-Hernández, Giovanni [UNESP] Tonin, Alexandre A. Pelinson, Luana P. Schetinger, Maria R. C. Morsch, Vera M. André, Marcos R. [UNESP] Machado, Rosangela Z. [UNESP] Tinucci-Costa, Mirela [UNESP] Da Silva, Aleksandro S. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Santa Maria Universidad Nacional de Colombia Universidade Estadual Paulista (Unesp) Universidade do Estado de Santa Catarina (UDESC) |
dc.contributor.author.fl_str_mv |
Bottari, Nathieli B. Vargas-Hernández, Giovanni [UNESP] Tonin, Alexandre A. Pelinson, Luana P. Schetinger, Maria R. C. Morsch, Vera M. André, Marcos R. [UNESP] Machado, Rosangela Z. [UNESP] Tinucci-Costa, Mirela [UNESP] Da Silva, Aleksandro S. |
dc.subject.por.fl_str_mv |
ADA Canids E. canis H. canis |
topic |
ADA Canids E. canis H. canis |
description |
Ehrlichia canis and Hepatozoon canis have been reported infecting a variety of Carnivora species worldwide, including domestic dogs and wild canids. Since both diseases can follow their course while the infected animals remain asymptomatic, assessments of different parameters that may help toward reaching a more accurate diagnosis are welcome. In this regard, the aim of the present study was to assess the activity of adenosine deaminase (ADA) in serum from naturally infected dogs. Forty-nine samples from dogs were used in our study: 15 positive for E. canis (8 asymptomatic and 7 symptomatic animals); 8 positive for H. canis; 14 with mixed infection; and 12 uninfected (used with control). Our results showed that the ADA activity was lower (P < 0.001) in serum from dogs with both infections singly and with mixed infection, in comparison with the uninfected animals (P < 0.001). The symptomatic dogs for E. canis had lower ADA activity when compared with asymptomatic dogs by H. canis (P < 0.01). Therefore, ADA activity reduces in positive dogs for E. canis and H. canis, which can be related to an inflammatory response against infection. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-13 2018-12-11T17:25:42Z 2018-12-11T17:25:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00580-015-2157-1 Comparative Clinical Pathology, v. 24, n. 5, p. 1289-1292, 2015. 1618-565X 1618-5641 http://hdl.handle.net/11449/177484 10.1007/s00580-015-2157-1 2-s2.0-84941316789 2-s2.0-84941316789.pdf |
url |
http://dx.doi.org/10.1007/s00580-015-2157-1 http://hdl.handle.net/11449/177484 |
identifier_str_mv |
Comparative Clinical Pathology, v. 24, n. 5, p. 1289-1292, 2015. 1618-565X 1618-5641 10.1007/s00580-015-2157-1 2-s2.0-84941316789 2-s2.0-84941316789.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Comparative Clinical Pathology 0,224 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1289-1292 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789683992756224 |