Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100050&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/128616 |
Resumo: | Introduction: Leptospirosis is a zoonosis that affects both humans and animals. Dogs may serve as sentinels and indicators of environmental contamination as well as potential carriers for Leptospira. This study aimed to evaluate the seroprevalence and seroincidence of leptospirosis infection in dogs in an urban low-income community in southern Brazil where human leptospirosis is endemic. Methods: A prospective cohort study was designed that consisted of sampling at recruitment and four consecutive trimestral follow-up sampling trials. All households in the area were visited, and those that owned dogs were invited to participate in the study. The seroprevalence (MAT titers >= 100) of Leptospira infection in dogs was calculated for each visit, the seroincidence (seroconversion or four-fold increase in serogroup-specific MAT titer) density rate was calculated for each follow-up, and a global seroincidence density rate was calculated for the overall period. Results: A total of 378 dogs and 902.7 dog-trimesters were recruited and followed, respectively. The seroprevalence of infection ranged from 9.3% (95% CI; 6.7 - 12.6) to 19% (14.1 - 25.2), the seroincidence density rate of infection ranged from 6% (3.3 - 10.6) to 15.3% (10.8 - 21.2), and the global seroincidence density rate of infection was 11% (9.1 - 13.2) per dog-trimester. Canicola and Icterohaemorraghiae were the most frequent incident serogroups observed in all follow-ups. Conclusions: Follow-ups with mean trimester intervals were incapable of detecting any increase in seroprevalence due to seroincident cases of canine leptospirosis, suggesting that antibody titers may fall within three months. Further studies on incident infections, disease burden or risk factors for incident Leptospira cases should take into account the detectable lifespan of the antibody. |
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Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern BrazilLeptospirosisDogsSeroincidenceSeroprevalenceSlumIntroduction: Leptospirosis is a zoonosis that affects both humans and animals. Dogs may serve as sentinels and indicators of environmental contamination as well as potential carriers for Leptospira. This study aimed to evaluate the seroprevalence and seroincidence of leptospirosis infection in dogs in an urban low-income community in southern Brazil where human leptospirosis is endemic. Methods: A prospective cohort study was designed that consisted of sampling at recruitment and four consecutive trimestral follow-up sampling trials. All households in the area were visited, and those that owned dogs were invited to participate in the study. The seroprevalence (MAT titers >= 100) of Leptospira infection in dogs was calculated for each visit, the seroincidence (seroconversion or four-fold increase in serogroup-specific MAT titer) density rate was calculated for each follow-up, and a global seroincidence density rate was calculated for the overall period. Results: A total of 378 dogs and 902.7 dog-trimesters were recruited and followed, respectively. The seroprevalence of infection ranged from 9.3% (95% CI; 6.7 - 12.6) to 19% (14.1 - 25.2), the seroincidence density rate of infection ranged from 6% (3.3 - 10.6) to 15.3% (10.8 - 21.2), and the global seroincidence density rate of infection was 11% (9.1 - 13.2) per dog-trimester. Canicola and Icterohaemorraghiae were the most frequent incident serogroups observed in all follow-ups. Conclusions: Follow-ups with mean trimester intervals were incapable of detecting any increase in seroprevalence due to seroincident cases of canine leptospirosis, suggesting that antibody titers may fall within three months. Further studies on incident infections, disease burden or risk factors for incident Leptospira cases should take into account the detectable lifespan of the antibody.Univ Fed Parana, Dept Vet Med, BR-80060000 Curitiba, PR, BrazilSecretaria Municipal Meio Ambiente, Dept Pesquisa Conservacao Fauna, BR-80810000 Curitiba, PR, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Microbiol &Imunol, Botucatu, SP, BrazilUniv Fed Bahia, Inst Saude Colet, Salvador, BA, BrazilUniv Estadual Paulista, Fac Med Vet &Zootecnia, Dept Higiene &Saude Publ, Botucatu, SP, BrazilUniv Illinois, Urbana, IL 61801 USAUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Microbiol e Imunol, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet e Zootecnia, Dept Higiene &Saude Publ, Botucatu, SP, BrazilSoc Brasileira Medicina TropicalUniversidade Federal do Paraná (UFPR)Secretaria Municipal Meio AmbienteUniversidade Estadual Paulista (Unesp)Universidade Federal da Bahia (UFBA)Univ IllinoisMorikawa, Vivien MidoriBier, DanielePellizzaro, MaysaUllmann, Leila Sabrina [UNESP]Dexheimer Paploski, Igor AdolfoKikuti, MarianaLangoni, Helio [UNESP]Biondo, Alexander WelkerMolento, Marcelo Beltrao2015-10-21T13:11:33Z2015-10-21T13:11:33Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article50-55application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100050&lng=en&nrm=iso&tlng=enRevista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 48, n. 1, p. 50-55, 2015.0037-8682http://hdl.handle.net/11449/12861610.1590/0037-8682-0213-2014S0037-86822015000100050WOS:000352735300009S0037-86822015000100050.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Da Sociedade Brasileira De Medicina Tropical1.3580,658info:eu-repo/semantics/openAccess2023-11-21T06:13:12Zoai:repositorio.unesp.br:11449/128616Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-21T06:13:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
title |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
spellingShingle |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil Morikawa, Vivien Midori Leptospirosis Dogs Seroincidence Seroprevalence Slum |
title_short |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
title_full |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
title_fullStr |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
title_full_unstemmed |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
title_sort |
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil |
author |
Morikawa, Vivien Midori |
author_facet |
Morikawa, Vivien Midori Bier, Daniele Pellizzaro, Maysa Ullmann, Leila Sabrina [UNESP] Dexheimer Paploski, Igor Adolfo Kikuti, Mariana Langoni, Helio [UNESP] Biondo, Alexander Welker Molento, Marcelo Beltrao |
author_role |
author |
author2 |
Bier, Daniele Pellizzaro, Maysa Ullmann, Leila Sabrina [UNESP] Dexheimer Paploski, Igor Adolfo Kikuti, Mariana Langoni, Helio [UNESP] Biondo, Alexander Welker Molento, Marcelo Beltrao |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Paraná (UFPR) Secretaria Municipal Meio Ambiente Universidade Estadual Paulista (Unesp) Universidade Federal da Bahia (UFBA) Univ Illinois |
dc.contributor.author.fl_str_mv |
Morikawa, Vivien Midori Bier, Daniele Pellizzaro, Maysa Ullmann, Leila Sabrina [UNESP] Dexheimer Paploski, Igor Adolfo Kikuti, Mariana Langoni, Helio [UNESP] Biondo, Alexander Welker Molento, Marcelo Beltrao |
dc.subject.por.fl_str_mv |
Leptospirosis Dogs Seroincidence Seroprevalence Slum |
topic |
Leptospirosis Dogs Seroincidence Seroprevalence Slum |
description |
Introduction: Leptospirosis is a zoonosis that affects both humans and animals. Dogs may serve as sentinels and indicators of environmental contamination as well as potential carriers for Leptospira. This study aimed to evaluate the seroprevalence and seroincidence of leptospirosis infection in dogs in an urban low-income community in southern Brazil where human leptospirosis is endemic. Methods: A prospective cohort study was designed that consisted of sampling at recruitment and four consecutive trimestral follow-up sampling trials. All households in the area were visited, and those that owned dogs were invited to participate in the study. The seroprevalence (MAT titers >= 100) of Leptospira infection in dogs was calculated for each visit, the seroincidence (seroconversion or four-fold increase in serogroup-specific MAT titer) density rate was calculated for each follow-up, and a global seroincidence density rate was calculated for the overall period. Results: A total of 378 dogs and 902.7 dog-trimesters were recruited and followed, respectively. The seroprevalence of infection ranged from 9.3% (95% CI; 6.7 - 12.6) to 19% (14.1 - 25.2), the seroincidence density rate of infection ranged from 6% (3.3 - 10.6) to 15.3% (10.8 - 21.2), and the global seroincidence density rate of infection was 11% (9.1 - 13.2) per dog-trimester. Canicola and Icterohaemorraghiae were the most frequent incident serogroups observed in all follow-ups. Conclusions: Follow-ups with mean trimester intervals were incapable of detecting any increase in seroprevalence due to seroincident cases of canine leptospirosis, suggesting that antibody titers may fall within three months. Further studies on incident infections, disease burden or risk factors for incident Leptospira cases should take into account the detectable lifespan of the antibody. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:11:33Z 2015-10-21T13:11:33Z 2015-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100050&lng=en&nrm=iso&tlng=en Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 48, n. 1, p. 50-55, 2015. 0037-8682 http://hdl.handle.net/11449/128616 10.1590/0037-8682-0213-2014 S0037-86822015000100050 WOS:000352735300009 S0037-86822015000100050.pdf |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100050&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/128616 |
identifier_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 48, n. 1, p. 50-55, 2015. 0037-8682 10.1590/0037-8682-0213-2014 S0037-86822015000100050 WOS:000352735300009 S0037-86822015000100050.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical 1.358 0,658 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
50-55 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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