Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.5935/1676-2444.20170010 http://hdl.handle.net/11449/169566 |
Resumo: | Primary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted with bone and abdomen pain, vomiting, fever, headache, anemia, elevated serum calcium and normal parathyroid hormone levels. Bone radiographs: osteolytic lesions. Bone marrow biopsy showed an infiltration by ALL with immunohistochemical positivity for CD45, CD20, CD79a, TdT and CD10, clinically characterized by hypercalcemia, multifocal osteolytic lesions and single cytopenia. Bone marrow biopsy was a relevant aid in establishing the diagnosis of multifocal osteolytic lesions, associated with hypercalcemia. |
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Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a childBone marrowHypercalcemiaPrecursor B-cell lymphoblastic leukemia-lymphomaPrimary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted with bone and abdomen pain, vomiting, fever, headache, anemia, elevated serum calcium and normal parathyroid hormone levels. Bone radiographs: osteolytic lesions. Bone marrow biopsy showed an infiltration by ALL with immunohistochemical positivity for CD45, CD20, CD79a, TdT and CD10, clinically characterized by hypercalcemia, multifocal osteolytic lesions and single cytopenia. Bone marrow biopsy was a relevant aid in establishing the diagnosis of multifocal osteolytic lesions, associated with hypercalcemia.Universidade Estadual Paulista (Unesp)Universidade Estadual Paulista (Unesp)Universidade Estadual Paulista (Unesp)Oliveira, Cristiano C. [UNESP]Kucko, Luan [UNESP]Hirama, Eric J. [UNESP]Guerra, Helena M. [UNESP]Terra, Simone A. [UNESP]Santiago, Lied M. [UNESP]Segredo, Manuella P. [UNESP]Niero-Melo, Ligia [UNESP]Domingues, Maria Aparecida C. [UNESP]2018-12-11T16:46:28Z2018-12-11T16:46:28Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article61-64application/pdfhttp://dx.doi.org/10.5935/1676-2444.20170010Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 53, n. 1, p. 61-64, 2017.1678-47741676-2444http://hdl.handle.net/11449/16956610.5935/1676-2444.20170010S1676-244420170001000612-s2.0-85015962367S1676-24442017000100061.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal Brasileiro de Patologia e Medicina Laboratorial0,143info:eu-repo/semantics/openAccess2023-12-25T06:20:42Zoai:repositorio.unesp.br:11449/169566Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-25T06:20:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| title |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| spellingShingle |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child Oliveira, Cristiano C. [UNESP] Bone marrow Hypercalcemia Precursor B-cell lymphoblastic leukemia-lymphoma |
| title_short |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| title_full |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| title_fullStr |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| title_full_unstemmed |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| title_sort |
Acute lymphoblastic leukemia: Primary bone manifestation with hypercalcemia in a child |
| author |
Oliveira, Cristiano C. [UNESP] |
| author_facet |
Oliveira, Cristiano C. [UNESP] Kucko, Luan [UNESP] Hirama, Eric J. [UNESP] Guerra, Helena M. [UNESP] Terra, Simone A. [UNESP] Santiago, Lied M. [UNESP] Segredo, Manuella P. [UNESP] Niero-Melo, Ligia [UNESP] Domingues, Maria Aparecida C. [UNESP] |
| author_role |
author |
| author2 |
Kucko, Luan [UNESP] Hirama, Eric J. [UNESP] Guerra, Helena M. [UNESP] Terra, Simone A. [UNESP] Santiago, Lied M. [UNESP] Segredo, Manuella P. [UNESP] Niero-Melo, Ligia [UNESP] Domingues, Maria Aparecida C. [UNESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Oliveira, Cristiano C. [UNESP] Kucko, Luan [UNESP] Hirama, Eric J. [UNESP] Guerra, Helena M. [UNESP] Terra, Simone A. [UNESP] Santiago, Lied M. [UNESP] Segredo, Manuella P. [UNESP] Niero-Melo, Ligia [UNESP] Domingues, Maria Aparecida C. [UNESP] |
| dc.subject.por.fl_str_mv |
Bone marrow Hypercalcemia Precursor B-cell lymphoblastic leukemia-lymphoma |
| topic |
Bone marrow Hypercalcemia Precursor B-cell lymphoblastic leukemia-lymphoma |
| description |
Primary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted with bone and abdomen pain, vomiting, fever, headache, anemia, elevated serum calcium and normal parathyroid hormone levels. Bone radiographs: osteolytic lesions. Bone marrow biopsy showed an infiltration by ALL with immunohistochemical positivity for CD45, CD20, CD79a, TdT and CD10, clinically characterized by hypercalcemia, multifocal osteolytic lesions and single cytopenia. Bone marrow biopsy was a relevant aid in establishing the diagnosis of multifocal osteolytic lesions, associated with hypercalcemia. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T16:46:28Z 2018-12-11T16:46:28Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/1676-2444.20170010 Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 53, n. 1, p. 61-64, 2017. 1678-4774 1676-2444 http://hdl.handle.net/11449/169566 10.5935/1676-2444.20170010 S1676-24442017000100061 2-s2.0-85015962367 S1676-24442017000100061.pdf |
| url |
http://dx.doi.org/10.5935/1676-2444.20170010 http://hdl.handle.net/11449/169566 |
| identifier_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 53, n. 1, p. 61-64, 2017. 1678-4774 1676-2444 10.5935/1676-2444.20170010 S1676-24442017000100061 2-s2.0-85015962367 S1676-24442017000100061.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial 0,143 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
61-64 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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|
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1799965401636929536 |