Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1477-7525-9-112 http://hdl.handle.net/11449/11470 |
Resumo: | Background: The association between disease markers and health status (HS) overtime is unclear. The aim of this study was to verify the predictors of HS at baseline and after three years in Chronic Obstructive Pulmonary Disease (COPD) patients.Methods: Ninety-five consecutive COPD patients (66% male, age = 67 +/- 9 y, FEV(1) = 58 +/- 23%) underwent the following evaluations at baseline and after three years: body composition, pulse oximetry (SpO(2)), six-minute walk distance (6MWD), Modified edical Research Council dyspnea scale (MMRC) and Saint George's Respiratory Questionnaire (SGRQ). The Charlson comorbidity index and BODE index were calculated. COPD exacerbations during the follow-up were evaluated. At baseline, age, gender, smoking, SpO(2), BODE index or its components (BMI, MMRC, FEV(1) and 6MWD), and Charlson index were included in a multiple linear regression analysis with the baseline SGRQ total score as the dependent variable. After three years, we included the final values of the variables plus the number of exacerbations and the final SGRQ total score as the dependent variable.Results: SGRQ total score (42 +/- 19% vs 44 +/- 19%; p = 0.041) and activity domain (52 +/- 21% vs 60 +/- 22%; p < 0.001) deteriorated during follow-up. At baseline, BODE index was selected as a predictor of SGRQ total score (R(2) = 0.46; p < 0.001); after three years, BODE index and age were the predictors (R(2) = 0.49; p < 0.001). When the BODE index was replaced by its variables, MMRC was selected as the only variable associated with the SGRQ total score (R(2) = 0.58; p < 0.001). After three years, MMRC, FEV(1) and number of exacerbations were selected as predictors of SGRQ total score (R(2) = 0.63; p < 0.001).Conclusion: HS deteriorated significantly over the three-year period and the predictors of HS do not change over time. BODE index and dyspnea were predictors at baseline and after three years. Exacerbation was also a predictor of HS after three years. |
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Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary diseaseCOPDHealth statusBODE indexdyspneaBackground: The association between disease markers and health status (HS) overtime is unclear. The aim of this study was to verify the predictors of HS at baseline and after three years in Chronic Obstructive Pulmonary Disease (COPD) patients.Methods: Ninety-five consecutive COPD patients (66% male, age = 67 +/- 9 y, FEV(1) = 58 +/- 23%) underwent the following evaluations at baseline and after three years: body composition, pulse oximetry (SpO(2)), six-minute walk distance (6MWD), Modified edical Research Council dyspnea scale (MMRC) and Saint George's Respiratory Questionnaire (SGRQ). The Charlson comorbidity index and BODE index were calculated. COPD exacerbations during the follow-up were evaluated. At baseline, age, gender, smoking, SpO(2), BODE index or its components (BMI, MMRC, FEV(1) and 6MWD), and Charlson index were included in a multiple linear regression analysis with the baseline SGRQ total score as the dependent variable. After three years, we included the final values of the variables plus the number of exacerbations and the final SGRQ total score as the dependent variable.Results: SGRQ total score (42 +/- 19% vs 44 +/- 19%; p = 0.041) and activity domain (52 +/- 21% vs 60 +/- 22%; p < 0.001) deteriorated during follow-up. At baseline, BODE index was selected as a predictor of SGRQ total score (R(2) = 0.46; p < 0.001); after three years, BODE index and age were the predictors (R(2) = 0.49; p < 0.001). When the BODE index was replaced by its variables, MMRC was selected as the only variable associated with the SGRQ total score (R(2) = 0.58; p < 0.001). After three years, MMRC, FEV(1) and number of exacerbations were selected as predictors of SGRQ total score (R(2) = 0.63; p < 0.001).Conclusion: HS deteriorated significantly over the three-year period and the predictors of HS do not change over time. BODE index and dyspnea were predictors at baseline and after three years. Exacerbation was also a predictor of HS after three years.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP Univ Estadual Paulista, Fac Med, Dept Clin Med, Botucatu, SP, BrazilUNESP Univ Estadual Paulista, Fac Med, Dept Clin Med, Botucatu, SP, BrazilFAPESP: 04/00517-4FAPESP: 08/52667-0Biomed Central Ltd.Universidade Estadual Paulista (Unesp)Ferrari, Renata [UNESP]Tanni, Suzana E. [UNESP]Caram, Laura M. O. [UNESP]Naves, Cristiane R. [UNESP]Godoy, Irma de [UNESP]2014-05-20T13:33:28Z2014-05-20T13:33:28Z2011-12-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://dx.doi.org/10.1186/1477-7525-9-112Health and Quality of Life Outcomes. London: Biomed Central Ltd., v. 9, p. 10, 2011.1477-7525http://hdl.handle.net/11449/1147010.1186/1477-7525-9-112WOS:000299050000001WOS000299050000001.pdf5079454858778041Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHealth and Quality of Life Outcomes2.2781,069info:eu-repo/semantics/openAccess2024-01-13T06:36:29Zoai:repositorio.unesp.br:11449/11470Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-13T06:36:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
title |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
spellingShingle |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease Ferrari, Renata [UNESP] COPD Health status BODE index dyspnea |
title_short |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
title_full |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
title_fullStr |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
title_full_unstemmed |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
title_sort |
Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease |
author |
Ferrari, Renata [UNESP] |
author_facet |
Ferrari, Renata [UNESP] Tanni, Suzana E. [UNESP] Caram, Laura M. O. [UNESP] Naves, Cristiane R. [UNESP] Godoy, Irma de [UNESP] |
author_role |
author |
author2 |
Tanni, Suzana E. [UNESP] Caram, Laura M. O. [UNESP] Naves, Cristiane R. [UNESP] Godoy, Irma de [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ferrari, Renata [UNESP] Tanni, Suzana E. [UNESP] Caram, Laura M. O. [UNESP] Naves, Cristiane R. [UNESP] Godoy, Irma de [UNESP] |
dc.subject.por.fl_str_mv |
COPD Health status BODE index dyspnea |
topic |
COPD Health status BODE index dyspnea |
description |
Background: The association between disease markers and health status (HS) overtime is unclear. The aim of this study was to verify the predictors of HS at baseline and after three years in Chronic Obstructive Pulmonary Disease (COPD) patients.Methods: Ninety-five consecutive COPD patients (66% male, age = 67 +/- 9 y, FEV(1) = 58 +/- 23%) underwent the following evaluations at baseline and after three years: body composition, pulse oximetry (SpO(2)), six-minute walk distance (6MWD), Modified edical Research Council dyspnea scale (MMRC) and Saint George's Respiratory Questionnaire (SGRQ). The Charlson comorbidity index and BODE index were calculated. COPD exacerbations during the follow-up were evaluated. At baseline, age, gender, smoking, SpO(2), BODE index or its components (BMI, MMRC, FEV(1) and 6MWD), and Charlson index were included in a multiple linear regression analysis with the baseline SGRQ total score as the dependent variable. After three years, we included the final values of the variables plus the number of exacerbations and the final SGRQ total score as the dependent variable.Results: SGRQ total score (42 +/- 19% vs 44 +/- 19%; p = 0.041) and activity domain (52 +/- 21% vs 60 +/- 22%; p < 0.001) deteriorated during follow-up. At baseline, BODE index was selected as a predictor of SGRQ total score (R(2) = 0.46; p < 0.001); after three years, BODE index and age were the predictors (R(2) = 0.49; p < 0.001). When the BODE index was replaced by its variables, MMRC was selected as the only variable associated with the SGRQ total score (R(2) = 0.58; p < 0.001). After three years, MMRC, FEV(1) and number of exacerbations were selected as predictors of SGRQ total score (R(2) = 0.63; p < 0.001).Conclusion: HS deteriorated significantly over the three-year period and the predictors of HS do not change over time. BODE index and dyspnea were predictors at baseline and after three years. Exacerbation was also a predictor of HS after three years. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-09 2014-05-20T13:33:28Z 2014-05-20T13:33:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1477-7525-9-112 Health and Quality of Life Outcomes. London: Biomed Central Ltd., v. 9, p. 10, 2011. 1477-7525 http://hdl.handle.net/11449/11470 10.1186/1477-7525-9-112 WOS:000299050000001 WOS000299050000001.pdf 5079454858778041 |
url |
http://dx.doi.org/10.1186/1477-7525-9-112 http://hdl.handle.net/11449/11470 |
identifier_str_mv |
Health and Quality of Life Outcomes. London: Biomed Central Ltd., v. 9, p. 10, 2011. 1477-7525 10.1186/1477-7525-9-112 WOS:000299050000001 WOS000299050000001.pdf 5079454858778041 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Health and Quality of Life Outcomes 2.278 1,069 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965607376977920 |