Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cyto.2017.09.030 http://hdl.handle.net/11449/164075 |
Resumo: | Depression and anxiety, the most important psychological disorders in cancer patients, have now been considered as psychoneuroimmunological disorders, in which peripheral immune activation, through the release of proinflammatory cytokines, is implicated in the variety of behavioral, neuroendocrine and neurochemical alterations associated with these disorders. Along with the tumor itself, cancer treatment can also contribute to exacerbate the production of proinflammatory cytokines. This study aimed to investigate whether proinflammatory cytokine levels are related to depression and anxiety in CRC patients in different stages of the antitumor therapy We evaluated 60 patients in three stages of antitumor therapy (Pre-chemotherapy, Under chemotherapy and Post-chemotherapy, n = 20 in each group) and 20 healthy volunteers by the Hospital Anxiety and Depression Scale (HADS). Serum levels of cytokines were measured by CBA. Depression and/or anxiety were found at clinically relevant levels in CRC patients during all antitumor therapy. Patients in pre-chemotherapy group exhibited the highest concentrations of pro-inflammatory cytokines and the lowest levels of IL-10. In latter stages of treatment, cytokines reached levels similar to the control group. Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1 beta, IL-6, IL-8, and TNF-alpha, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients. A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of new therapeutic strategies to assist in alleviating such symptoms in cancer patients. |
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Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapyCytokinesAnxietyDepressionColorectal cancerDepression and anxiety, the most important psychological disorders in cancer patients, have now been considered as psychoneuroimmunological disorders, in which peripheral immune activation, through the release of proinflammatory cytokines, is implicated in the variety of behavioral, neuroendocrine and neurochemical alterations associated with these disorders. Along with the tumor itself, cancer treatment can also contribute to exacerbate the production of proinflammatory cytokines. This study aimed to investigate whether proinflammatory cytokine levels are related to depression and anxiety in CRC patients in different stages of the antitumor therapy We evaluated 60 patients in three stages of antitumor therapy (Pre-chemotherapy, Under chemotherapy and Post-chemotherapy, n = 20 in each group) and 20 healthy volunteers by the Hospital Anxiety and Depression Scale (HADS). Serum levels of cytokines were measured by CBA. Depression and/or anxiety were found at clinically relevant levels in CRC patients during all antitumor therapy. Patients in pre-chemotherapy group exhibited the highest concentrations of pro-inflammatory cytokines and the lowest levels of IL-10. In latter stages of treatment, cytokines reached levels similar to the control group. Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1 beta, IL-6, IL-8, and TNF-alpha, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients. A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of new therapeutic strategies to assist in alleviating such symptoms in cancer patients.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Ribeirao Preto Coll Nursing, Ribeirao Preto, BrazilSao Paulo State Univ, Dept Biol, Inst Biosci Language & Literature & Exact Sci, Sao Jose Do Rio Preto, BrazilUniv Sao Paulo, Ribeirao Preto Sch Med, Dept Internal Med, Ribeirao Preto, BrazilUniv Sao Paulo, Ribeirao Preto Coll Nursing, Postgrad Program Publ Hlth Nursing, Ribeirao Preto, BrazilSao Paulo State Univ, Dept Biol, Inst Biosci Language & Literature & Exact Sci, Sao Jose Do Rio Preto, BrazilFAPESP: 2011/17118-9FAPESP: 2013/01262-9Elsevier B.V.Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Miranda, Diego O.Anatriello, ElenAzevedo, Lucas R. [UNESP]Cordeiro, Jessica F. C.Peria, Fernanda M.Floria-Santos, MilenaPereira-da-Silva, Gabriela2018-11-26T17:49:00Z2018-11-26T17:49:00Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article72-77application/pdfhttp://dx.doi.org/10.1016/j.cyto.2017.09.030Cytokine. London: Academic Press Ltd- Elsevier Science Ltd, v. 104, p. 72-77, 2018.1043-4666http://hdl.handle.net/11449/16407510.1016/j.cyto.2017.09.030WOS:000429393800012WOS000429393800012.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCytokine1,433info:eu-repo/semantics/openAccess2023-09-30T06:00:31Zoai:repositorio.unesp.br:11449/164075Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-09-30T06:00:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
title |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
spellingShingle |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy Miranda, Diego O. Cytokines Anxiety Depression Colorectal cancer |
title_short |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
title_full |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
title_fullStr |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
title_full_unstemmed |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
title_sort |
Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy |
author |
Miranda, Diego O. |
author_facet |
Miranda, Diego O. Anatriello, Elen Azevedo, Lucas R. [UNESP] Cordeiro, Jessica F. C. Peria, Fernanda M. Floria-Santos, Milena Pereira-da-Silva, Gabriela |
author_role |
author |
author2 |
Anatriello, Elen Azevedo, Lucas R. [UNESP] Cordeiro, Jessica F. C. Peria, Fernanda M. Floria-Santos, Milena Pereira-da-Silva, Gabriela |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Miranda, Diego O. Anatriello, Elen Azevedo, Lucas R. [UNESP] Cordeiro, Jessica F. C. Peria, Fernanda M. Floria-Santos, Milena Pereira-da-Silva, Gabriela |
dc.subject.por.fl_str_mv |
Cytokines Anxiety Depression Colorectal cancer |
topic |
Cytokines Anxiety Depression Colorectal cancer |
description |
Depression and anxiety, the most important psychological disorders in cancer patients, have now been considered as psychoneuroimmunological disorders, in which peripheral immune activation, through the release of proinflammatory cytokines, is implicated in the variety of behavioral, neuroendocrine and neurochemical alterations associated with these disorders. Along with the tumor itself, cancer treatment can also contribute to exacerbate the production of proinflammatory cytokines. This study aimed to investigate whether proinflammatory cytokine levels are related to depression and anxiety in CRC patients in different stages of the antitumor therapy We evaluated 60 patients in three stages of antitumor therapy (Pre-chemotherapy, Under chemotherapy and Post-chemotherapy, n = 20 in each group) and 20 healthy volunteers by the Hospital Anxiety and Depression Scale (HADS). Serum levels of cytokines were measured by CBA. Depression and/or anxiety were found at clinically relevant levels in CRC patients during all antitumor therapy. Patients in pre-chemotherapy group exhibited the highest concentrations of pro-inflammatory cytokines and the lowest levels of IL-10. In latter stages of treatment, cytokines reached levels similar to the control group. Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1 beta, IL-6, IL-8, and TNF-alpha, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients. A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of new therapeutic strategies to assist in alleviating such symptoms in cancer patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:49:00Z 2018-11-26T17:49:00Z 2018-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cyto.2017.09.030 Cytokine. London: Academic Press Ltd- Elsevier Science Ltd, v. 104, p. 72-77, 2018. 1043-4666 http://hdl.handle.net/11449/164075 10.1016/j.cyto.2017.09.030 WOS:000429393800012 WOS000429393800012.pdf |
url |
http://dx.doi.org/10.1016/j.cyto.2017.09.030 http://hdl.handle.net/11449/164075 |
identifier_str_mv |
Cytokine. London: Academic Press Ltd- Elsevier Science Ltd, v. 104, p. 72-77, 2018. 1043-4666 10.1016/j.cyto.2017.09.030 WOS:000429393800012 WOS000429393800012.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cytokine 1,433 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
72-77 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792961416459714560 |