Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0004-282X20190172 http://hdl.handle.net/11449/197336 |
Resumo: | Ischemic stroke is a common cause of death. The role of statins in the secondary prevention of the chronic ischemic stroke phase has been established. However, evidence regarding their efficacy in this phase is limited and contradictory. Objective: To evaluate the association between statin use and mortality risk during the acute phase of ischemic stroke in patients admitted to an intensive care unit. Methods: This was an observational and prospective study of ischemic stroke patients aged >= 18, admitted to an intensive care unit. Medications used during the first 7 days after the ictus, as well as medications used previously, were recorded. The primary outcome was all-cause mortality during the first 7 days. Results: We screened 212 patients and included 97 patients with ischemic stroke in the study period.The mortality rate among patients who used statins during the acute IS phase [14% (9/63)]was significantly lower than that among patients who did not use statins [41% (14/34); p=0.007]. This was confirmed in logistical regression with an 0.19 Odds Ratio - OR [p=0.018; 95% confidence interval - 95%CI 0.05-0.75]. Patients who died were older, had a higher incidence of acute myocardial infarction, higher scores on the NIHSS and lower systolic blood pressure. Statins and angiotensin converting enzyme inhibitors were used more frequently among survivors. These associations persisted even after adjustment for confounding variables. Conclusion: Statins and angiotensin converting enzyme inhibitors use during hospitalization were independently associated to a lower rate of all-cause mortality in the first 7 days of intensive care unit admission. |
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Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unitstrokestatinsintensive care unitmortalityIschemic stroke is a common cause of death. The role of statins in the secondary prevention of the chronic ischemic stroke phase has been established. However, evidence regarding their efficacy in this phase is limited and contradictory. Objective: To evaluate the association between statin use and mortality risk during the acute phase of ischemic stroke in patients admitted to an intensive care unit. Methods: This was an observational and prospective study of ischemic stroke patients aged >= 18, admitted to an intensive care unit. Medications used during the first 7 days after the ictus, as well as medications used previously, were recorded. The primary outcome was all-cause mortality during the first 7 days. Results: We screened 212 patients and included 97 patients with ischemic stroke in the study period.The mortality rate among patients who used statins during the acute IS phase [14% (9/63)]was significantly lower than that among patients who did not use statins [41% (14/34); p=0.007]. This was confirmed in logistical regression with an 0.19 Odds Ratio - OR [p=0.018; 95% confidence interval - 95%CI 0.05-0.75]. Patients who died were older, had a higher incidence of acute myocardial infarction, higher scores on the NIHSS and lower systolic blood pressure. Statins and angiotensin converting enzyme inhibitors were used more frequently among survivors. These associations persisted even after adjustment for confounding variables. Conclusion: Statins and angiotensin converting enzyme inhibitors use during hospitalization were independently associated to a lower rate of all-cause mortality in the first 7 days of intensive care unit admission.Univ Estado Sao Paulo, Fac Med, Dept Med Interna, Botucatu, SP, BrazilUniv Fed Triangulo Mineiro, Dept Fisioterapia Aplicada, Uberaba, MG, BrazilUniv Estado Sao Paulo, Fac Med, Dept Neurol Psicol & Psiquiatria, Botucatu, SP, BrazilAssoc Arquivos Neuro- PsiquiatriaUniv Estado Sao PauloUniv Fed Triangulo MineiroUniversidade Estadual Paulista (Unesp)Furlan, Natalia EduardaSouza, Juli Thomaz deZanati Bazan, Silmeia GarciaSilva Franco, Roberto Jorge daLuvizutto, Gustavo JoseGut, Ana LuciaModolo, Gabriel PinheiroWinckler, Fernanda CristinaMartin, Luis CuadradoBazan, Rodrigo2020-12-10T20:13:48Z2020-12-10T20:13:48Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article158-162application/pdfhttp://dx.doi.org/10.1590/0004-282X20190172Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 78, n. 3, p. 158-162, 2020.0004-282Xhttp://hdl.handle.net/11449/19733610.1590/0004-282X20190172S0004-282X2020000300158WOS:000530031000006S0004-282X2020000300158.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos De Neuro-psiquiatriainfo:eu-repo/semantics/openAccess2024-01-14T06:22:43Zoai:repositorio.unesp.br:11449/197336Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-14T06:22:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
title |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
spellingShingle |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit Furlan, Natalia Eduarda stroke statins intensive care unit mortality |
title_short |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
title_full |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
title_fullStr |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
title_full_unstemmed |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
title_sort |
Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit |
author |
Furlan, Natalia Eduarda |
author_facet |
Furlan, Natalia Eduarda Souza, Juli Thomaz de Zanati Bazan, Silmeia Garcia Silva Franco, Roberto Jorge da Luvizutto, Gustavo Jose Gut, Ana Lucia Modolo, Gabriel Pinheiro Winckler, Fernanda Cristina Martin, Luis Cuadrado Bazan, Rodrigo |
author_role |
author |
author2 |
Souza, Juli Thomaz de Zanati Bazan, Silmeia Garcia Silva Franco, Roberto Jorge da Luvizutto, Gustavo Jose Gut, Ana Lucia Modolo, Gabriel Pinheiro Winckler, Fernanda Cristina Martin, Luis Cuadrado Bazan, Rodrigo |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Estado Sao Paulo Univ Fed Triangulo Mineiro Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Furlan, Natalia Eduarda Souza, Juli Thomaz de Zanati Bazan, Silmeia Garcia Silva Franco, Roberto Jorge da Luvizutto, Gustavo Jose Gut, Ana Lucia Modolo, Gabriel Pinheiro Winckler, Fernanda Cristina Martin, Luis Cuadrado Bazan, Rodrigo |
dc.subject.por.fl_str_mv |
stroke statins intensive care unit mortality |
topic |
stroke statins intensive care unit mortality |
description |
Ischemic stroke is a common cause of death. The role of statins in the secondary prevention of the chronic ischemic stroke phase has been established. However, evidence regarding their efficacy in this phase is limited and contradictory. Objective: To evaluate the association between statin use and mortality risk during the acute phase of ischemic stroke in patients admitted to an intensive care unit. Methods: This was an observational and prospective study of ischemic stroke patients aged >= 18, admitted to an intensive care unit. Medications used during the first 7 days after the ictus, as well as medications used previously, were recorded. The primary outcome was all-cause mortality during the first 7 days. Results: We screened 212 patients and included 97 patients with ischemic stroke in the study period.The mortality rate among patients who used statins during the acute IS phase [14% (9/63)]was significantly lower than that among patients who did not use statins [41% (14/34); p=0.007]. This was confirmed in logistical regression with an 0.19 Odds Ratio - OR [p=0.018; 95% confidence interval - 95%CI 0.05-0.75]. Patients who died were older, had a higher incidence of acute myocardial infarction, higher scores on the NIHSS and lower systolic blood pressure. Statins and angiotensin converting enzyme inhibitors were used more frequently among survivors. These associations persisted even after adjustment for confounding variables. Conclusion: Statins and angiotensin converting enzyme inhibitors use during hospitalization were independently associated to a lower rate of all-cause mortality in the first 7 days of intensive care unit admission. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T20:13:48Z 2020-12-10T20:13:48Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0004-282X20190172 Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 78, n. 3, p. 158-162, 2020. 0004-282X http://hdl.handle.net/11449/197336 10.1590/0004-282X20190172 S0004-282X2020000300158 WOS:000530031000006 S0004-282X2020000300158.pdf |
url |
http://dx.doi.org/10.1590/0004-282X20190172 http://hdl.handle.net/11449/197336 |
identifier_str_mv |
Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 78, n. 3, p. 158-162, 2020. 0004-282X 10.1590/0004-282X20190172 S0004-282X2020000300158 WOS:000530031000006 S0004-282X2020000300158.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos De Neuro-psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
158-162 application/pdf |
dc.publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797790292373405696 |