Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ijms12042757 http://hdl.handle.net/11449/8069 |
Resumo: | Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi. |
id |
UNSP_7568571697e764f22a9029fe184f7f67 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/8069 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchiEndopleura uchiminimum inhibitory concentrationIC(50)tanninsEndopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, BR-502 Araraquara, SP, BrazilUniversidade Estadual de Maringá (UEM), Dept Pharm, BR-87020900 Maringa, PR, BrazilUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Dept Nat Act Principles & Toxicol, BR-502 Araraquara, SP, BrazilUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, BR-502 Araraquara, SP, BrazilUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Dept Nat Act Principles & Toxicol, BR-502 Araraquara, SP, BrazilMdpi AgUniversidade Estadual Paulista (Unesp)Universidade Estadual de Maringá (UEM)Politi, Flavio A. S. [UNESP]de Mello, Joao C. P.Migliato, Ketylin F. [UNESP]Nepomuceno, Andrea L. A. [UNESP]Moreira, Raquel Regina Duarte [UNESP]Pietro, Rosemeire C. L. R. [UNESP]2014-05-20T13:25:29Z2014-05-20T13:25:29Z2011-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2757-2768application/pdfhttp://dx.doi.org/10.3390/ijms12042757International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 12, n. 4, p. 2757-2768, 2011.1661-6596http://hdl.handle.net/11449/806910.3390/ijms12042757WOS:000289974600018WOS000289974600018.pdf77103444618649240000-0002-4253-0320Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Molecular Sciencesinfo:eu-repo/semantics/openAccess2023-10-27T06:06:04Zoai:repositorio.unesp.br:11449/8069Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-27T06:06:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
title |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
spellingShingle |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi Politi, Flavio A. S. [UNESP] Endopleura uchi minimum inhibitory concentration IC(50) tannins |
title_short |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
title_full |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
title_fullStr |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
title_full_unstemmed |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
title_sort |
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi |
author |
Politi, Flavio A. S. [UNESP] |
author_facet |
Politi, Flavio A. S. [UNESP] de Mello, Joao C. P. Migliato, Ketylin F. [UNESP] Nepomuceno, Andrea L. A. [UNESP] Moreira, Raquel Regina Duarte [UNESP] Pietro, Rosemeire C. L. R. [UNESP] |
author_role |
author |
author2 |
de Mello, Joao C. P. Migliato, Ketylin F. [UNESP] Nepomuceno, Andrea L. A. [UNESP] Moreira, Raquel Regina Duarte [UNESP] Pietro, Rosemeire C. L. R. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Maringá (UEM) |
dc.contributor.author.fl_str_mv |
Politi, Flavio A. S. [UNESP] de Mello, Joao C. P. Migliato, Ketylin F. [UNESP] Nepomuceno, Andrea L. A. [UNESP] Moreira, Raquel Regina Duarte [UNESP] Pietro, Rosemeire C. L. R. [UNESP] |
dc.subject.por.fl_str_mv |
Endopleura uchi minimum inhibitory concentration IC(50) tannins |
topic |
Endopleura uchi minimum inhibitory concentration IC(50) tannins |
description |
Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04-01 2014-05-20T13:25:29Z 2014-05-20T13:25:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ijms12042757 International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 12, n. 4, p. 2757-2768, 2011. 1661-6596 http://hdl.handle.net/11449/8069 10.3390/ijms12042757 WOS:000289974600018 WOS000289974600018.pdf 7710344461864924 0000-0002-4253-0320 |
url |
http://dx.doi.org/10.3390/ijms12042757 http://hdl.handle.net/11449/8069 |
identifier_str_mv |
International Journal of Molecular Sciences. Basel: Mdpi Ag, v. 12, n. 4, p. 2757-2768, 2011. 1661-6596 10.3390/ijms12042757 WOS:000289974600018 WOS000289974600018.pdf 7710344461864924 0000-0002-4253-0320 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Molecular Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2757-2768 application/pdf |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789523824869376 |