Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1152/japplphysiol.00321.2019 http://hdl.handle.net/11449/196441 |
Resumo: | The study investigated the influence of beta-alanine supplementation during a high-intensity interval training (HIIT) program on repeated sprint ability (RSA) performance. This study was randomized, double-blinded, and placebo controlled. Eighteen men performed an incremental running test until exhaustion (T-INC) at baseline and followed by 4-wk HIIT (10 x 1min runs 90% maximal T-INC velocity [1-min recovery]). Then, participants were randomized into two groups and performed a 6-wk HIIT associated with supplementation of 6.4 g/day of beta-alanine (G beta) or dextrose (placebo group; GP). Pre- and post-6-wk HIIT + supplementation, participants performed the following tests: 1) T-INC; 2) supramaximal running test; and 3) 2 x 6 x 35-m sprints (RSA). Before and immediately after RSA, neuromuscular function was assessed by vertical jumps, maximal isometric voluntary contractions of knee extension, and neuromuscular electrical stimulations. Muscle biopsies were performed to determine muscle carnosine content, muscle buffering capacity in vitro (beta m(in) (vitro)), and content of phos-phofructokinase (PFK), monocarboxylate transporter 4 (MCT4), and hypoxia-inducible factor-1 alpha (HIF-1 alpha). Both groups showed a significant time effect for maximal oxygen uptake (G beta: 6.2 +/- 3.6% and GP: 6.5 +/- 4.2%; P > 0.01); only G beta showed a time effect for total (-3.0 +/- 2.0%; P > 0.001) and best (-3.3 +/- 3.0%; P = 0.03) RSA times. A group-by-time interaction was shown after HIIT + Supplementation for muscle carnosine (G beta: 34.4 +/- 2.3 mmol.kg(-1).dm(-1) and GP: 20.7 +/- 3.0 mmol.kg(-1) dm(-1); P = 0.003) and neuromuscular voluntary activation after RSA (G beta: 87.2 +/- 3.3% and GP: 78.9 +/- 12.4%; P = 0.02). No time effect or group-by-time interaction was shown for supramaximal running test performance, beta m, and content of PFK, MCT4, and HIF-1 alpha. In summary, beta-alanine supplementation during HIIT increased muscle carnosine and attenuated neuromuscular fatigue, which may contribute to an enhancement of RSA performance. NEW & NOTEWORTHY beta-Alanine supplementation during a high-intensity interval training program increased repeated sprint performance. The improvement of muscle carnosine content induced by beta-alanine supplementation may have contributed to an attenuation of central fatigue during repeated sprint. Overall, beta-alanine supplementation may be a useful dietary intervention to prevent fatigue. |
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Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigueanaerobic capacitymuscle buffering capacitymuscle carnosineWestern blotThe study investigated the influence of beta-alanine supplementation during a high-intensity interval training (HIIT) program on repeated sprint ability (RSA) performance. This study was randomized, double-blinded, and placebo controlled. Eighteen men performed an incremental running test until exhaustion (T-INC) at baseline and followed by 4-wk HIIT (10 x 1min runs 90% maximal T-INC velocity [1-min recovery]). Then, participants were randomized into two groups and performed a 6-wk HIIT associated with supplementation of 6.4 g/day of beta-alanine (G beta) or dextrose (placebo group; GP). Pre- and post-6-wk HIIT + supplementation, participants performed the following tests: 1) T-INC; 2) supramaximal running test; and 3) 2 x 6 x 35-m sprints (RSA). Before and immediately after RSA, neuromuscular function was assessed by vertical jumps, maximal isometric voluntary contractions of knee extension, and neuromuscular electrical stimulations. Muscle biopsies were performed to determine muscle carnosine content, muscle buffering capacity in vitro (beta m(in) (vitro)), and content of phos-phofructokinase (PFK), monocarboxylate transporter 4 (MCT4), and hypoxia-inducible factor-1 alpha (HIF-1 alpha). Both groups showed a significant time effect for maximal oxygen uptake (G beta: 6.2 +/- 3.6% and GP: 6.5 +/- 4.2%; P > 0.01); only G beta showed a time effect for total (-3.0 +/- 2.0%; P > 0.001) and best (-3.3 +/- 3.0%; P = 0.03) RSA times. A group-by-time interaction was shown after HIIT + Supplementation for muscle carnosine (G beta: 34.4 +/- 2.3 mmol.kg(-1).dm(-1) and GP: 20.7 +/- 3.0 mmol.kg(-1) dm(-1); P = 0.003) and neuromuscular voluntary activation after RSA (G beta: 87.2 +/- 3.3% and GP: 78.9 +/- 12.4%; P = 0.02). No time effect or group-by-time interaction was shown for supramaximal running test performance, beta m, and content of PFK, MCT4, and HIF-1 alpha. In summary, beta-alanine supplementation during HIIT increased muscle carnosine and attenuated neuromuscular fatigue, which may contribute to an enhancement of RSA performance. NEW & NOTEWORTHY beta-Alanine supplementation during a high-intensity interval training program increased repeated sprint performance. The improvement of muscle carnosine content induced by beta-alanine supplementation may have contributed to an attenuation of central fatigue during repeated sprint. Overall, beta-alanine supplementation may be a useful dietary intervention to prevent fatigue.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sao Paulo State Univ, Lab Physiol & Human Performance, Post Grad Program Human Movement Sci, Bauru, SP, BrazilUniv Sao Paulo, Fac Med, Sch Phys Educ & Sport, Rheumatol Div,Appl Physiol & Nutr Res Grp, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Inst Orthopaed & Traumatol, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, Ribeirao Preto, SP, BrazilMato Grosso do Sul Fed Univ, Lab Resp Pathophysiol, Sao Paulo, SP, BrazilSao Paulo State Univ, Fac Sci, Dept Phys Educ, Bauru, SP, BrazilSao Paulo State Univ, Lab Physiol & Human Performance, Post Grad Program Human Movement Sci, Bauru, SP, BrazilSao Paulo State Univ, Fac Sci, Dept Phys Educ, Bauru, SP, BrazilFAPESP: 2016/02683-6FAPESP: 2016/11076-6FAPESP: 2016/17836-2FAPESP: 2016/50438-0CNPq: 307719/2016-2CAPES: 001Amer Physiological SocUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Mato Grosso do Sul Fed UnivMilioni, Fabio [UNESP]Bonetti de Poli, Rodrigo Araujo [UNESP]Saunders, BryanGualano, BrunoRocha, Alisson L. daRamos da Silva, Adelino SanchezGuerrero Muller, Paulo de TarsoZagatto, Alessandro Moura [UNESP]2020-12-10T19:45:06Z2020-12-10T19:45:06Z2019-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1599-1610http://dx.doi.org/10.1152/japplphysiol.00321.2019Journal Of Applied Physiology. Bethesda: Amer Physiological Soc, v. 127, n. 6, p. 1599-1610, 2019.8750-7587http://hdl.handle.net/11449/19644110.1152/japplphysiol.00321.2019WOS:000504408200011Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Applied Physiologyinfo:eu-repo/semantics/openAccess2024-04-24T18:53:09Zoai:repositorio.unesp.br:11449/196441Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-24T18:53:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
title |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
spellingShingle |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue Milioni, Fabio [UNESP] anaerobic capacity muscle buffering capacity muscle carnosine Western blot |
title_short |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
title_full |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
title_fullStr |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
title_full_unstemmed |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
title_sort |
Effect of beta-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue |
author |
Milioni, Fabio [UNESP] |
author_facet |
Milioni, Fabio [UNESP] Bonetti de Poli, Rodrigo Araujo [UNESP] Saunders, Bryan Gualano, Bruno Rocha, Alisson L. da Ramos da Silva, Adelino Sanchez Guerrero Muller, Paulo de Tarso Zagatto, Alessandro Moura [UNESP] |
author_role |
author |
author2 |
Bonetti de Poli, Rodrigo Araujo [UNESP] Saunders, Bryan Gualano, Bruno Rocha, Alisson L. da Ramos da Silva, Adelino Sanchez Guerrero Muller, Paulo de Tarso Zagatto, Alessandro Moura [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Mato Grosso do Sul Fed Univ |
dc.contributor.author.fl_str_mv |
Milioni, Fabio [UNESP] Bonetti de Poli, Rodrigo Araujo [UNESP] Saunders, Bryan Gualano, Bruno Rocha, Alisson L. da Ramos da Silva, Adelino Sanchez Guerrero Muller, Paulo de Tarso Zagatto, Alessandro Moura [UNESP] |
dc.subject.por.fl_str_mv |
anaerobic capacity muscle buffering capacity muscle carnosine Western blot |
topic |
anaerobic capacity muscle buffering capacity muscle carnosine Western blot |
description |
The study investigated the influence of beta-alanine supplementation during a high-intensity interval training (HIIT) program on repeated sprint ability (RSA) performance. This study was randomized, double-blinded, and placebo controlled. Eighteen men performed an incremental running test until exhaustion (T-INC) at baseline and followed by 4-wk HIIT (10 x 1min runs 90% maximal T-INC velocity [1-min recovery]). Then, participants were randomized into two groups and performed a 6-wk HIIT associated with supplementation of 6.4 g/day of beta-alanine (G beta) or dextrose (placebo group; GP). Pre- and post-6-wk HIIT + supplementation, participants performed the following tests: 1) T-INC; 2) supramaximal running test; and 3) 2 x 6 x 35-m sprints (RSA). Before and immediately after RSA, neuromuscular function was assessed by vertical jumps, maximal isometric voluntary contractions of knee extension, and neuromuscular electrical stimulations. Muscle biopsies were performed to determine muscle carnosine content, muscle buffering capacity in vitro (beta m(in) (vitro)), and content of phos-phofructokinase (PFK), monocarboxylate transporter 4 (MCT4), and hypoxia-inducible factor-1 alpha (HIF-1 alpha). Both groups showed a significant time effect for maximal oxygen uptake (G beta: 6.2 +/- 3.6% and GP: 6.5 +/- 4.2%; P > 0.01); only G beta showed a time effect for total (-3.0 +/- 2.0%; P > 0.001) and best (-3.3 +/- 3.0%; P = 0.03) RSA times. A group-by-time interaction was shown after HIIT + Supplementation for muscle carnosine (G beta: 34.4 +/- 2.3 mmol.kg(-1).dm(-1) and GP: 20.7 +/- 3.0 mmol.kg(-1) dm(-1); P = 0.003) and neuromuscular voluntary activation after RSA (G beta: 87.2 +/- 3.3% and GP: 78.9 +/- 12.4%; P = 0.02). No time effect or group-by-time interaction was shown for supramaximal running test performance, beta m, and content of PFK, MCT4, and HIF-1 alpha. In summary, beta-alanine supplementation during HIIT increased muscle carnosine and attenuated neuromuscular fatigue, which may contribute to an enhancement of RSA performance. NEW & NOTEWORTHY beta-Alanine supplementation during a high-intensity interval training program increased repeated sprint performance. The improvement of muscle carnosine content induced by beta-alanine supplementation may have contributed to an attenuation of central fatigue during repeated sprint. Overall, beta-alanine supplementation may be a useful dietary intervention to prevent fatigue. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 2020-12-10T19:45:06Z 2020-12-10T19:45:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1152/japplphysiol.00321.2019 Journal Of Applied Physiology. Bethesda: Amer Physiological Soc, v. 127, n. 6, p. 1599-1610, 2019. 8750-7587 http://hdl.handle.net/11449/196441 10.1152/japplphysiol.00321.2019 WOS:000504408200011 |
url |
http://dx.doi.org/10.1152/japplphysiol.00321.2019 http://hdl.handle.net/11449/196441 |
identifier_str_mv |
Journal Of Applied Physiology. Bethesda: Amer Physiological Soc, v. 127, n. 6, p. 1599-1610, 2019. 8750-7587 10.1152/japplphysiol.00321.2019 WOS:000504408200011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Applied Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1599-1610 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789559662051328 |