Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system

Detalhes bibliográficos
Autor(a) principal: Roberto, Matheus Mantuanelli [UNESP]
Data de Publicação: 2016
Outros Autores: Jamal, Claudia Masrouah, Malaspina, Osmar [UNESP], Marin-Morales, Maria Aparecida [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-4685-GMB-2015-0130
http://hdl.handle.net/11449/161624
Resumo: Brazilian green propolis is a resinous substance prepared by bees from parts of the plant Baccharis dracunculifolia. As it possess several biological properties, this work assessed the cytotoxic/anticytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic potential of ethanolic extracts of Brazilian green propolis (EEGP) and of B. dracunculifolia (EEBD), by means of the Allium cepa test system. The effects were evaluated by assessing the chromosomal aberrations (CA) and micronuclei (MN) frequencies on meristematic and F1 generation cells from onion roots. Chemical analyses performed with the extracts showed differences in flavonoid quality and quantity. No genotoxic or mutagenic potential was detected, and both extracts were capable of inhibiting cellular damage caused by methyl methanesulfonate (MMS) treatment, reducing the frequencies of CA and MN. By these data, we can infer that, independent of their flavonoid content, the extracts presented a protective effect in A. cepa cells against the clastogenicity of MMS.
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spelling Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test systemchromosomal aberrationmicronucleusanticlastogenicityprotective effectsflavonoidsBrazilian green propolis is a resinous substance prepared by bees from parts of the plant Baccharis dracunculifolia. As it possess several biological properties, this work assessed the cytotoxic/anticytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic potential of ethanolic extracts of Brazilian green propolis (EEGP) and of B. dracunculifolia (EEBD), by means of the Allium cepa test system. The effects were evaluated by assessing the chromosomal aberrations (CA) and micronuclei (MN) frequencies on meristematic and F1 generation cells from onion roots. Chemical analyses performed with the extracts showed differences in flavonoid quality and quantity. No genotoxic or mutagenic potential was detected, and both extracts were capable of inhibiting cellular damage caused by methyl methanesulfonate (MMS) treatment, reducing the frequencies of CA and MN. By these data, we can infer that, independent of their flavonoid content, the extracts presented a protective effect in A. cepa cells against the clastogenicity of MMS.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Inst Biociencias, Dept Biol, Rio Claro, SP, BrazilUniv Fed Espirito Santo, Centro Ciencias Saude, Dept Ciencias Farmaceut, Vitoria, ES, SpainUniv Estadual Paulista, Ctr Estudo Insetos Sociais, Rio Claro, SP, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Biol, Rio Claro, SP, BrazilUniv Estadual Paulista, Ctr Estudo Insetos Sociais, Rio Claro, SP, BrazilSoc Brasil GeneticaUniversidade Estadual Paulista (Unesp)Univ Fed Espirito SantoRoberto, Matheus Mantuanelli [UNESP]Jamal, Claudia MasrouahMalaspina, Osmar [UNESP]Marin-Morales, Maria Aparecida [UNESP]2018-11-26T16:40:42Z2018-11-26T16:40:42Z2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article257-269application/pdfhttp://dx.doi.org/10.1590/1678-4685-GMB-2015-0130Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 39, n. 2, p. 257-269, 2016.1415-4757http://hdl.handle.net/11449/16162410.1590/1678-4685-GMB-2015-0130S1415-47572016000200257WOS:000378135600014S1415-47572016000200257.pdf75385560855058190000-0002-1650-257XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics And Molecular Biology0,638info:eu-repo/semantics/openAccess2023-11-02T06:13:14Zoai:repositorio.unesp.br:11449/161624Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-02T06:13:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
title Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
spellingShingle Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
Roberto, Matheus Mantuanelli [UNESP]
chromosomal aberration
micronucleus
anticlastogenicity
protective effects
flavonoids
title_short Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
title_full Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
title_fullStr Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
title_full_unstemmed Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
title_sort Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
author Roberto, Matheus Mantuanelli [UNESP]
author_facet Roberto, Matheus Mantuanelli [UNESP]
Jamal, Claudia Masrouah
Malaspina, Osmar [UNESP]
Marin-Morales, Maria Aparecida [UNESP]
author_role author
author2 Jamal, Claudia Masrouah
Malaspina, Osmar [UNESP]
Marin-Morales, Maria Aparecida [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Univ Fed Espirito Santo
dc.contributor.author.fl_str_mv Roberto, Matheus Mantuanelli [UNESP]
Jamal, Claudia Masrouah
Malaspina, Osmar [UNESP]
Marin-Morales, Maria Aparecida [UNESP]
dc.subject.por.fl_str_mv chromosomal aberration
micronucleus
anticlastogenicity
protective effects
flavonoids
topic chromosomal aberration
micronucleus
anticlastogenicity
protective effects
flavonoids
description Brazilian green propolis is a resinous substance prepared by bees from parts of the plant Baccharis dracunculifolia. As it possess several biological properties, this work assessed the cytotoxic/anticytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic potential of ethanolic extracts of Brazilian green propolis (EEGP) and of B. dracunculifolia (EEBD), by means of the Allium cepa test system. The effects were evaluated by assessing the chromosomal aberrations (CA) and micronuclei (MN) frequencies on meristematic and F1 generation cells from onion roots. Chemical analyses performed with the extracts showed differences in flavonoid quality and quantity. No genotoxic or mutagenic potential was detected, and both extracts were capable of inhibiting cellular damage caused by methyl methanesulfonate (MMS) treatment, reducing the frequencies of CA and MN. By these data, we can infer that, independent of their flavonoid content, the extracts presented a protective effect in A. cepa cells against the clastogenicity of MMS.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
2018-11-26T16:40:42Z
2018-11-26T16:40:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-4685-GMB-2015-0130
Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 39, n. 2, p. 257-269, 2016.
1415-4757
http://hdl.handle.net/11449/161624
10.1590/1678-4685-GMB-2015-0130
S1415-47572016000200257
WOS:000378135600014
S1415-47572016000200257.pdf
7538556085505819
0000-0002-1650-257X
url http://dx.doi.org/10.1590/1678-4685-GMB-2015-0130
http://hdl.handle.net/11449/161624
identifier_str_mv Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 39, n. 2, p. 257-269, 2016.
1415-4757
10.1590/1678-4685-GMB-2015-0130
S1415-47572016000200257
WOS:000378135600014
S1415-47572016000200257.pdf
7538556085505819
0000-0002-1650-257X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics And Molecular Biology
0,638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 257-269
application/pdf
dc.publisher.none.fl_str_mv Soc Brasil Genetica
publisher.none.fl_str_mv Soc Brasil Genetica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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