Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1039/d0nr08693b http://hdl.handle.net/11449/206080 |
Resumo: | Loading active ingredients on nanocarrier systems is becoming a common strategy for improving pesticide formulations. One of the most important properties of these nanoformulations is the proportion of pesticide associated with the nanocarriers (encapsulation efficiency, EE). EE is often determined by centrifugal ultrafiltration. However, the losses of active ingredient in the centrifugal ultrafiltration devices are typically not assessed, potentially leading to erroneous results. In this work, the losses of three pesticides (tebuconazole, terbuthylazine and chlorpyrifos) during centrifugal ultrafiltration have been systematically evaluated for nine different devices. Results suggest that centrifugal ultrafiltration is not suitable for determining the EE of compounds such as chlorpyrifos as 100% losses were observed on all the devices tested. Losses of tebuconazole and terbuthylazine were highly variable according to the type of membrane and the lowest losses were observed in the devices with hydrophilic regenerated cellulose membranes. Based on these results, we propose a correction factor and demonstrate its application to calculate the EE of two nanoformulations based on poly(ϵ-caprolactone) nanocarriers. The approach extends the applicability of centrifugal ultrafiltration to a wider range of pesticide nanoformulations. We also discuss the effect of dilution on EE and make recommendations to improve the characterisation of nanoparticles-based pesticide nanoformulations in the future. This journal is |
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Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?Loading active ingredients on nanocarrier systems is becoming a common strategy for improving pesticide formulations. One of the most important properties of these nanoformulations is the proportion of pesticide associated with the nanocarriers (encapsulation efficiency, EE). EE is often determined by centrifugal ultrafiltration. However, the losses of active ingredient in the centrifugal ultrafiltration devices are typically not assessed, potentially leading to erroneous results. In this work, the losses of three pesticides (tebuconazole, terbuthylazine and chlorpyrifos) during centrifugal ultrafiltration have been systematically evaluated for nine different devices. Results suggest that centrifugal ultrafiltration is not suitable for determining the EE of compounds such as chlorpyrifos as 100% losses were observed on all the devices tested. Losses of tebuconazole and terbuthylazine were highly variable according to the type of membrane and the lowest losses were observed in the devices with hydrophilic regenerated cellulose membranes. Based on these results, we propose a correction factor and demonstrate its application to calculate the EE of two nanoformulations based on poly(ϵ-caprolactone) nanocarriers. The approach extends the applicability of centrifugal ultrafiltration to a wider range of pesticide nanoformulations. We also discuss the effect of dilution on EE and make recommendations to improve the characterisation of nanoparticles-based pesticide nanoformulations in the future. This journal isResearch Centre for Toxic Compounds in the Environment (RECETOX) Faculty of Science Masaryk University, Kamenice 753/5School of Environment University of Auckland, 23 Symonds StreetSão Paulo State University (UNESP) Department of Physics and Chemistry School of Sciences and EngineeringSão Paulo State University (UNESP) Department of Physics and Chemistry School of Sciences and EngineeringMasaryk UniversityUniversity of AucklandUniversidade Estadual Paulista (Unesp)López-Cabeza, RocíoKah, MelanieGrillo, Renato [UNESP]Bílková, ZuzanaHofman, Jakub2021-06-25T10:26:14Z2021-06-25T10:26:14Z2021-03-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5410-5418http://dx.doi.org/10.1039/d0nr08693bNanoscale, v. 13, n. 10, p. 5410-5418, 2021.2040-33722040-3364http://hdl.handle.net/11449/20608010.1039/d0nr08693b2-s2.0-85102860594Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanoscaleinfo:eu-repo/semantics/openAccess2021-10-22T20:56:08Zoai:repositorio.unesp.br:11449/206080Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T20:56:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
title |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
spellingShingle |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? López-Cabeza, Rocío |
title_short |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
title_full |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
title_fullStr |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
title_full_unstemmed |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
title_sort |
Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? |
author |
López-Cabeza, Rocío |
author_facet |
López-Cabeza, Rocío Kah, Melanie Grillo, Renato [UNESP] Bílková, Zuzana Hofman, Jakub |
author_role |
author |
author2 |
Kah, Melanie Grillo, Renato [UNESP] Bílková, Zuzana Hofman, Jakub |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Masaryk University University of Auckland Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
López-Cabeza, Rocío Kah, Melanie Grillo, Renato [UNESP] Bílková, Zuzana Hofman, Jakub |
description |
Loading active ingredients on nanocarrier systems is becoming a common strategy for improving pesticide formulations. One of the most important properties of these nanoformulations is the proportion of pesticide associated with the nanocarriers (encapsulation efficiency, EE). EE is often determined by centrifugal ultrafiltration. However, the losses of active ingredient in the centrifugal ultrafiltration devices are typically not assessed, potentially leading to erroneous results. In this work, the losses of three pesticides (tebuconazole, terbuthylazine and chlorpyrifos) during centrifugal ultrafiltration have been systematically evaluated for nine different devices. Results suggest that centrifugal ultrafiltration is not suitable for determining the EE of compounds such as chlorpyrifos as 100% losses were observed on all the devices tested. Losses of tebuconazole and terbuthylazine were highly variable according to the type of membrane and the lowest losses were observed in the devices with hydrophilic regenerated cellulose membranes. Based on these results, we propose a correction factor and demonstrate its application to calculate the EE of two nanoformulations based on poly(ϵ-caprolactone) nanocarriers. The approach extends the applicability of centrifugal ultrafiltration to a wider range of pesticide nanoformulations. We also discuss the effect of dilution on EE and make recommendations to improve the characterisation of nanoparticles-based pesticide nanoformulations in the future. This journal is |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:26:14Z 2021-06-25T10:26:14Z 2021-03-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1039/d0nr08693b Nanoscale, v. 13, n. 10, p. 5410-5418, 2021. 2040-3372 2040-3364 http://hdl.handle.net/11449/206080 10.1039/d0nr08693b 2-s2.0-85102860594 |
url |
http://dx.doi.org/10.1039/d0nr08693b http://hdl.handle.net/11449/206080 |
identifier_str_mv |
Nanoscale, v. 13, n. 10, p. 5410-5418, 2021. 2040-3372 2040-3364 10.1039/d0nr08693b 2-s2.0-85102860594 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nanoscale |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5410-5418 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965436908929024 |