Behavior of cardiac variables in animals exposed to cigarette smoke
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0066-782X2003001100002 http://hdl.handle.net/11449/26435 |
Resumo: | OBJECTIVE: To assess the behavior of cardiac variables in animals exposed to cigarette smoke. METHODS: Two groups of Wistar rats were studied as follows: control group (C), comprising 28 animals; and smoking group (S), comprising 23 animals exposed to cigarette smoke for 30 days. Left ventricular cardiac function was assessed in vivo with transthoracic echocardiography, and myocardial performance was analyzed in vitro in preparations of isolated left ventricular papillary muscle. The cardiac muscle was assessed in isometric contractions with an extracellular calcium concentration of 2.5 mmol/L. RESULTS: No statistical difference was observed in the values of the body variables of the rats and in the mechanical data obtained from the papillary muscle between the control and smoking groups. The values of left ventricular systolic diameter were significantly greater in the smoking animals than in the control animals (C= 3.39 ± 0.4 mm and S= 3.71 ± 0.51 mm, P=0.02). A significant reduction was observed in systolic shortening fraction (C= 56.7 ± 4.2% and S= 53.5 ± 5.3%, P=0.02) and in ejection fraction (C= 0.92 ± 0.02 and S= 0.89 ± 0.04, P=0.01). CONCLUSION: The rats exposed to cigarette smoke had a reduction in left ventricular systolic function, although their myocardial function was preserved. |
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Behavior of cardiac variables in animals exposed to cigarette smokesmokingleft ventricular junctioncigaretteechocardiographyOBJECTIVE: To assess the behavior of cardiac variables in animals exposed to cigarette smoke. METHODS: Two groups of Wistar rats were studied as follows: control group (C), comprising 28 animals; and smoking group (S), comprising 23 animals exposed to cigarette smoke for 30 days. Left ventricular cardiac function was assessed in vivo with transthoracic echocardiography, and myocardial performance was analyzed in vitro in preparations of isolated left ventricular papillary muscle. The cardiac muscle was assessed in isometric contractions with an extracellular calcium concentration of 2.5 mmol/L. RESULTS: No statistical difference was observed in the values of the body variables of the rats and in the mechanical data obtained from the papillary muscle between the control and smoking groups. The values of left ventricular systolic diameter were significantly greater in the smoking animals than in the control animals (C= 3.39 ± 0.4 mm and S= 3.71 ± 0.51 mm, P=0.02). A significant reduction was observed in systolic shortening fraction (C= 56.7 ± 4.2% and S= 53.5 ± 5.3%, P=0.02) and in ejection fraction (C= 0.92 ± 0.02 and S= 0.89 ± 0.04, P=0.01). CONCLUSION: The rats exposed to cigarette smoke had a reduction in left ventricular systolic function, although their myocardial function was preserved.Universidade Estadual Paulista Faculdade de Medicina de BotucatuUniversidade Estadual Paulista Faculdade de Medicina de BotucatuSociedade Brasileira de Cardiologia (SBC)Universidade Estadual Paulista (Unesp)Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Okoshi, Marina Politi [UNESP]Okoshi, Katashi [UNESP]Cicogna, Antonio Carlos [UNESP]Campana, Alvaro Oscar [UNESP]2014-05-20T15:07:16Z2014-05-20T15:07:16Z2003-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article225-228application/pdfhttp://dx.doi.org/10.1590/S0066-782X2003001100002Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 81, n. 3, p. 225-228, 2003.0066-782Xhttp://hdl.handle.net/11449/2643510.1590/S0066-782X2003001100002S0066-782X2003001100002S0066-782X2003001100002.pdf44631386719984321590971576309420941897010356413750168390153945470000-0002-9831-8820SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2023-11-18T06:17:03Zoai:repositorio.unesp.br:11449/26435Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-18T06:17:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Behavior of cardiac variables in animals exposed to cigarette smoke |
title |
Behavior of cardiac variables in animals exposed to cigarette smoke |
spellingShingle |
Behavior of cardiac variables in animals exposed to cigarette smoke Paiva, Sergio Alberto Rupp de [UNESP] smoking left ventricular junction cigarette echocardiography |
title_short |
Behavior of cardiac variables in animals exposed to cigarette smoke |
title_full |
Behavior of cardiac variables in animals exposed to cigarette smoke |
title_fullStr |
Behavior of cardiac variables in animals exposed to cigarette smoke |
title_full_unstemmed |
Behavior of cardiac variables in animals exposed to cigarette smoke |
title_sort |
Behavior of cardiac variables in animals exposed to cigarette smoke |
author |
Paiva, Sergio Alberto Rupp de [UNESP] |
author_facet |
Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio Carlos [UNESP] Campana, Alvaro Oscar [UNESP] |
author_role |
author |
author2 |
Zornoff, Leonardo Antonio Mamede [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio Carlos [UNESP] Campana, Alvaro Oscar [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio Carlos [UNESP] Campana, Alvaro Oscar [UNESP] |
dc.subject.por.fl_str_mv |
smoking left ventricular junction cigarette echocardiography |
topic |
smoking left ventricular junction cigarette echocardiography |
description |
OBJECTIVE: To assess the behavior of cardiac variables in animals exposed to cigarette smoke. METHODS: Two groups of Wistar rats were studied as follows: control group (C), comprising 28 animals; and smoking group (S), comprising 23 animals exposed to cigarette smoke for 30 days. Left ventricular cardiac function was assessed in vivo with transthoracic echocardiography, and myocardial performance was analyzed in vitro in preparations of isolated left ventricular papillary muscle. The cardiac muscle was assessed in isometric contractions with an extracellular calcium concentration of 2.5 mmol/L. RESULTS: No statistical difference was observed in the values of the body variables of the rats and in the mechanical data obtained from the papillary muscle between the control and smoking groups. The values of left ventricular systolic diameter were significantly greater in the smoking animals than in the control animals (C= 3.39 ± 0.4 mm and S= 3.71 ± 0.51 mm, P=0.02). A significant reduction was observed in systolic shortening fraction (C= 56.7 ± 4.2% and S= 53.5 ± 5.3%, P=0.02) and in ejection fraction (C= 0.92 ± 0.02 and S= 0.89 ± 0.04, P=0.01). CONCLUSION: The rats exposed to cigarette smoke had a reduction in left ventricular systolic function, although their myocardial function was preserved. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-09-01 2014-05-20T15:07:16Z 2014-05-20T15:07:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0066-782X2003001100002 Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 81, n. 3, p. 225-228, 2003. 0066-782X http://hdl.handle.net/11449/26435 10.1590/S0066-782X2003001100002 S0066-782X2003001100002 S0066-782X2003001100002.pdf 4463138671998432 1590971576309420 9418970103564137 5016839015394547 0000-0002-9831-8820 |
url |
http://dx.doi.org/10.1590/S0066-782X2003001100002 http://hdl.handle.net/11449/26435 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 81, n. 3, p. 225-228, 2003. 0066-782X 10.1590/S0066-782X2003001100002 S0066-782X2003001100002 S0066-782X2003001100002.pdf 4463138671998432 1590971576309420 9418970103564137 5016839015394547 0000-0002-9831-8820 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
225-228 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia (SBC) |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia (SBC) |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789748557774848 |