Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-29612016054 http://hdl.handle.net/11449/173516 |
Resumo: | The aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0.0307) and liver (P=0.0346). There was a significant correlation between apoptosis and parasite load (P = 0.0084; r=0.3104) only in the spleen of the infected group, where it was observed that, when increasing the number of apoptotic cells increases the parasitic load. It was concluded that the liver and spleen of infected dogs presented greater numbers of cells undergoing apoptosis (lymphocytes) than the control group, thus suggesting that this process may be contributing towards the survival of Leishmania in these organs, because lymphocyte in apoptosis did not have the ability to present and recognize the antigen, allowing the survival of the parasite. |
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Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceralInfluence of apoptosis on liver and spleen resistance in dogs with visceral leishmaniosisApoptosisDogsImmune escapeLeishmania infantumThe aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0.0307) and liver (P=0.0346). There was a significant correlation between apoptosis and parasite load (P = 0.0084; r=0.3104) only in the spleen of the infected group, where it was observed that, when increasing the number of apoptotic cells increases the parasitic load. It was concluded that the liver and spleen of infected dogs presented greater numbers of cells undergoing apoptosis (lymphocytes) than the control group, thus suggesting that this process may be contributing towards the survival of Leishmania in these organs, because lymphocyte in apoptosis did not have the ability to present and recognize the antigen, allowing the survival of the parasite.Departamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPFaculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPDepartamento de Ciências Exatas Faculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPDepartamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPFaculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPDepartamento de Ciências Exatas Faculdade de Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESPUniversidade Estadual Paulista (Unesp)Moreira, Pamela Rodrigues Reina [UNESP]Franciscato, Douglas Augusto [UNESP]Rossit, Sabrina Micelli [UNESP]Munari, Danísio Prado [UNESP]Vasconcelos, Rosemeri de Oliveira [UNESP]2018-12-11T17:06:03Z2018-12-11T17:06:03Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article341-347application/pdfhttp://dx.doi.org/10.1590/S1984-29612016054Revista Brasileira de Parasitologia Veterinaria, v. 25, n. 3, p. 341-347, 2016.0103-846Xhttp://hdl.handle.net/11449/17351610.1590/S1984-29612016054S1984-296120160003003422-s2.0-84988645666S1984-29612016000300342.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Parasitologia Veterinariainfo:eu-repo/semantics/openAccess2023-12-10T06:15:29Zoai:repositorio.unesp.br:11449/173516Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-10T06:15:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral Influence of apoptosis on liver and spleen resistance in dogs with visceral leishmaniosis |
title |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
spellingShingle |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral Moreira, Pamela Rodrigues Reina [UNESP] Apoptosis Dogs Immune escape Leishmania infantum |
title_short |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
title_full |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
title_fullStr |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
title_full_unstemmed |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
title_sort |
Influência da apoptose na resistência hepática e esplênica de cães com leishmaniose visceral |
author |
Moreira, Pamela Rodrigues Reina [UNESP] |
author_facet |
Moreira, Pamela Rodrigues Reina [UNESP] Franciscato, Douglas Augusto [UNESP] Rossit, Sabrina Micelli [UNESP] Munari, Danísio Prado [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
author_role |
author |
author2 |
Franciscato, Douglas Augusto [UNESP] Rossit, Sabrina Micelli [UNESP] Munari, Danísio Prado [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Moreira, Pamela Rodrigues Reina [UNESP] Franciscato, Douglas Augusto [UNESP] Rossit, Sabrina Micelli [UNESP] Munari, Danísio Prado [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
dc.subject.por.fl_str_mv |
Apoptosis Dogs Immune escape Leishmania infantum |
topic |
Apoptosis Dogs Immune escape Leishmania infantum |
description |
The aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0.0307) and liver (P=0.0346). There was a significant correlation between apoptosis and parasite load (P = 0.0084; r=0.3104) only in the spleen of the infected group, where it was observed that, when increasing the number of apoptotic cells increases the parasitic load. It was concluded that the liver and spleen of infected dogs presented greater numbers of cells undergoing apoptosis (lymphocytes) than the control group, thus suggesting that this process may be contributing towards the survival of Leishmania in these organs, because lymphocyte in apoptosis did not have the ability to present and recognize the antigen, allowing the survival of the parasite. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 2018-12-11T17:06:03Z 2018-12-11T17:06:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-29612016054 Revista Brasileira de Parasitologia Veterinaria, v. 25, n. 3, p. 341-347, 2016. 0103-846X http://hdl.handle.net/11449/173516 10.1590/S1984-29612016054 S1984-29612016000300342 2-s2.0-84988645666 S1984-29612016000300342.pdf |
url |
http://dx.doi.org/10.1590/S1984-29612016054 http://hdl.handle.net/11449/173516 |
identifier_str_mv |
Revista Brasileira de Parasitologia Veterinaria, v. 25, n. 3, p. 341-347, 2016. 0103-846X 10.1590/S1984-29612016054 S1984-29612016000300342 2-s2.0-84988645666 S1984-29612016000300342.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinaria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
341-347 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792962039530913792 |