Estudo biomecânico e morfológico da cicatrização da parede abdominal sob ação de meloxicam

• Autor(a) principal: Tognini, João Ricardo F.
• Data de Publicação: 2000
• Outros Autores: Fagundes, Djalma José [UNESP], Novo, Neil Ferreira [UNESP], Juliano, Yara [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0102-86502000000300003; http://hdl.handle.net/11449/211408
• topic: Meloxicam; Abdominal muscles; Wound healing; Collagenous; Rats; Meloxicam; Músculos abdominais; Cicatrização de feridas; Colágeno; Ratos

A biomechanical / morphological study in rats’ abdominal wall healing and Meloxicam was performed in 120 male wistar rats. The 60 animals in the control group were injected Meloxicam IM (0,5mg.kg-1) or saline soluction (NaCl 0,9%) in the initial four consecutive days. The 60 animals in the experimental group carried out standart laparotomie and closure. Each animal in the initial four days was injected meloxicam or saline soluction in the same way of the control group. About the 5th, 10th or 15th post-operative day the animals weith-body were measured and segments of the operated abdominal wall was submitted to tensile strength test and hystological analysis (collagenous and macrophages counters with spetial PC-software). Statistical analysis was considered at 5%. The body weight records showed better performance in the animals injected with Meloxicam at five-day observation, probably due to less pain in post-operative period. The tensiometer test showed no statistical differences in all groups, just like the histological counters and qualitative analysis of collagenous tissue and macrophages, showing that Meloxicam had no interference in abdominal wall healing. The findings led us to conclude that Meloxicam doen’t provide biomechanical and morphological healing alterations in rat’s abdominal operative scars.