Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.18433/j3p01j http://hdl.handle.net/11449/232021 |
Resumo: | Purpose: Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. Objectives: to estimate the prevalence of elderly who had used PIM before being admitted to hospital and to identify the risk factors and the hospitalizations related to ADR arising from PIM. Methods: A descriptive and cross-sectional study was performed in the internal medicine ward of a teaching hospital (Brazil), in 2008. With the aid of a validated form, patients aged ≥ 60 years, with length of hospital stay ≥ 24 hours, were interviewed about drugs taken prior to the hospital admission and the complaints/reasons for hospitalization. Results: 19.1% (59/308) of older patients had taken PIM before hospital admission and in 4.9%; there were a causal relation between the PIM taken and the complaint reported. PIM responsible for admissions were: amiodarone, amitriptyline, cimetidine, clonidine, diazepam, digoxin, estrogen, fluoxetine, lorazepam, short-acting nifedipine and propranolol. 47.0% of the clinical manifestations of PIM-related ADR were: dizziness, fatigue, digoxin toxicity and erythema. Only polypharmacy was detected as a risk factor for the occurrence of ADR of PIM (p = 0.02). Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM. |
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Repositório Institucional da UNESP |
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Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admissionPurpose: Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. Objectives: to estimate the prevalence of elderly who had used PIM before being admitted to hospital and to identify the risk factors and the hospitalizations related to ADR arising from PIM. Methods: A descriptive and cross-sectional study was performed in the internal medicine ward of a teaching hospital (Brazil), in 2008. With the aid of a validated form, patients aged ≥ 60 years, with length of hospital stay ≥ 24 hours, were interviewed about drugs taken prior to the hospital admission and the complaints/reasons for hospitalization. Results: 19.1% (59/308) of older patients had taken PIM before hospital admission and in 4.9%; there were a causal relation between the PIM taken and the complaint reported. PIM responsible for admissions were: amiodarone, amitriptyline, cimetidine, clonidine, diazepam, digoxin, estrogen, fluoxetine, lorazepam, short-acting nifedipine and propranolol. 47.0% of the clinical manifestations of PIM-related ADR were: dizziness, fatigue, digoxin toxicity and erythema. Only polypharmacy was detected as a risk factor for the occurrence of ADR of PIM (p = 0.02). Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM.School of Pharmaceutical Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)Risk Management of Clinical Hospital of Ribeirão Preto University of São Paulo-Ribeirão PretoSchool of Pharmaceutical Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Varallo, Fabiana Rossi [UNESP]Capucho, Helaine CarneiroPlaneta, Cleópatra Silva [UNESP]Mastroianni, Patrícia de Carvalho [UNESP]2022-04-29T08:48:43Z2022-04-29T08:48:43Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article283-290http://dx.doi.org/10.18433/j3p01jJournal of Pharmacy and Pharmaceutical Sciences, v. 14, n. 2, p. 283-290, 2011.1482-1826http://hdl.handle.net/11449/23202110.18433/j3p01j2-s2.0-79961163059Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Pharmacy and Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccess2022-04-29T08:48:43Zoai:repositorio.unesp.br:11449/232021Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:48:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
title |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
spellingShingle |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission Varallo, Fabiana Rossi [UNESP] |
title_short |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
title_full |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
title_fullStr |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
title_full_unstemmed |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
title_sort |
Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission |
author |
Varallo, Fabiana Rossi [UNESP] |
author_facet |
Varallo, Fabiana Rossi [UNESP] Capucho, Helaine Carneiro Planeta, Cleópatra Silva [UNESP] Mastroianni, Patrícia de Carvalho [UNESP] |
author_role |
author |
author2 |
Capucho, Helaine Carneiro Planeta, Cleópatra Silva [UNESP] Mastroianni, Patrícia de Carvalho [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Varallo, Fabiana Rossi [UNESP] Capucho, Helaine Carneiro Planeta, Cleópatra Silva [UNESP] Mastroianni, Patrícia de Carvalho [UNESP] |
description |
Purpose: Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. Objectives: to estimate the prevalence of elderly who had used PIM before being admitted to hospital and to identify the risk factors and the hospitalizations related to ADR arising from PIM. Methods: A descriptive and cross-sectional study was performed in the internal medicine ward of a teaching hospital (Brazil), in 2008. With the aid of a validated form, patients aged ≥ 60 years, with length of hospital stay ≥ 24 hours, were interviewed about drugs taken prior to the hospital admission and the complaints/reasons for hospitalization. Results: 19.1% (59/308) of older patients had taken PIM before hospital admission and in 4.9%; there were a causal relation between the PIM taken and the complaint reported. PIM responsible for admissions were: amiodarone, amitriptyline, cimetidine, clonidine, diazepam, digoxin, estrogen, fluoxetine, lorazepam, short-acting nifedipine and propranolol. 47.0% of the clinical manifestations of PIM-related ADR were: dizziness, fatigue, digoxin toxicity and erythema. Only polypharmacy was detected as a risk factor for the occurrence of ADR of PIM (p = 0.02). Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2022-04-29T08:48:43Z 2022-04-29T08:48:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.18433/j3p01j Journal of Pharmacy and Pharmaceutical Sciences, v. 14, n. 2, p. 283-290, 2011. 1482-1826 http://hdl.handle.net/11449/232021 10.18433/j3p01j 2-s2.0-79961163059 |
url |
http://dx.doi.org/10.18433/j3p01j http://hdl.handle.net/11449/232021 |
identifier_str_mv |
Journal of Pharmacy and Pharmaceutical Sciences, v. 14, n. 2, p. 283-290, 2011. 1482-1826 10.18433/j3p01j 2-s2.0-79961163059 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Pharmacy and Pharmaceutical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
283-290 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965579022434304 |