Lack of Epstein-Barr virus infection in cervical carcinomas
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224118 |
Resumo: | Context. - The Epstein-Barr virus (EBV) is a ubiquitous microorganism strongly associated with lymphoproliferative disorders and a large number of human neoplasms, mainly undifferentiated nasopharyngeal carcinoma and Burkitt lymphoma. The viral DNA has been detected in other tumors, such as carcinomas from tonsil, salivary glands, and thymus, and malignancies of the female genital tract. Some authors have proposed that EBV could play a role in the carcinogenesis of cervical tumors; however, other studies do not support this hypothesis. Objective. - To assess whether EBV is associated with female genital tract neoplasms. Design. - Sixty-five biopsy specimens (5 in situ carcinomas, 24 invasive squamous cell carcinomas, 6 lymphoepithelioma-like carcinomas, and 30 endocervical adenocarcinomas) were used to perform EBV detection through RNA in situ hybridization. Results. - None of the cervical carcinoma cases studied was positive for EBV infection. Conclusions. - The results suggest that it is still premature to incriminate EBV in the carcinogenesis of cervical carcinoma. |
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Lack of Epstein-Barr virus infection in cervical carcinomasContext. - The Epstein-Barr virus (EBV) is a ubiquitous microorganism strongly associated with lymphoproliferative disorders and a large number of human neoplasms, mainly undifferentiated nasopharyngeal carcinoma and Burkitt lymphoma. The viral DNA has been detected in other tumors, such as carcinomas from tonsil, salivary glands, and thymus, and malignancies of the female genital tract. Some authors have proposed that EBV could play a role in the carcinogenesis of cervical tumors; however, other studies do not support this hypothesis. Objective. - To assess whether EBV is associated with female genital tract neoplasms. Design. - Sixty-five biopsy specimens (5 in situ carcinomas, 24 invasive squamous cell carcinomas, 6 lymphoepithelioma-like carcinomas, and 30 endocervical adenocarcinomas) were used to perform EBV detection through RNA in situ hybridization. Results. - None of the cervical carcinoma cases studied was positive for EBV infection. Conclusions. - The results suggest that it is still premature to incriminate EBV in the carcinogenesis of cervical carcinoma.Department of Pathology Botucatu School of Medicine Universidade Estadual Paulista, BotucatuEvandro Chagas Research Institute, BelemDepartment of Pathology School of Medicine Federal University of Goias, GoiâniaDepartment of Gynecology School of Medicine Universidade de Campinas, CampinasPathology Department Botucatu School of Medicine Universidade Estadual Paulista, PO Box 564, Botucatu, São Paulo 18618-000Department of Pathology Botucatu School of Medicine Universidade Estadual Paulista, BotucatuPathology Department Botucatu School of Medicine Universidade Estadual Paulista, PO Box 564, Botucatu, São Paulo 18618-000Universidade Estadual Paulista (UNESP)Evandro Chagas Research InstituteFederal University of GoiasUniversidade Estadual de Campinas (UNICAMP)De Oliveira, Deilson Elgui [UNESP]Monteiro, Talita Antônia FurtadoDe Melo, Wyller AlencarMoreira, Manse Amaral RebouçasAlvarenga, MarceloBacchi, Carlos E. [UNESP]2022-04-28T19:54:50Z2022-04-28T19:54:50Z1999-11-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1098-1100Archives of Pathology and Laboratory Medicine, v. 123, n. 11, p. 1098-1100, 1999.0003-9985http://hdl.handle.net/11449/2241182-s2.0-0032698009Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Pathology and Laboratory Medicineinfo:eu-repo/semantics/openAccess2022-04-28T19:54:50Zoai:repositorio.unesp.br:11449/224118Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:54:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lack of Epstein-Barr virus infection in cervical carcinomas |
title |
Lack of Epstein-Barr virus infection in cervical carcinomas |
spellingShingle |
Lack of Epstein-Barr virus infection in cervical carcinomas De Oliveira, Deilson Elgui [UNESP] |
title_short |
Lack of Epstein-Barr virus infection in cervical carcinomas |
title_full |
Lack of Epstein-Barr virus infection in cervical carcinomas |
title_fullStr |
Lack of Epstein-Barr virus infection in cervical carcinomas |
title_full_unstemmed |
Lack of Epstein-Barr virus infection in cervical carcinomas |
title_sort |
Lack of Epstein-Barr virus infection in cervical carcinomas |
author |
De Oliveira, Deilson Elgui [UNESP] |
author_facet |
De Oliveira, Deilson Elgui [UNESP] Monteiro, Talita Antônia Furtado De Melo, Wyller Alencar Moreira, Manse Amaral Rebouças Alvarenga, Marcelo Bacchi, Carlos E. [UNESP] |
author_role |
author |
author2 |
Monteiro, Talita Antônia Furtado De Melo, Wyller Alencar Moreira, Manse Amaral Rebouças Alvarenga, Marcelo Bacchi, Carlos E. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Evandro Chagas Research Institute Federal University of Goias Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
De Oliveira, Deilson Elgui [UNESP] Monteiro, Talita Antônia Furtado De Melo, Wyller Alencar Moreira, Manse Amaral Rebouças Alvarenga, Marcelo Bacchi, Carlos E. [UNESP] |
description |
Context. - The Epstein-Barr virus (EBV) is a ubiquitous microorganism strongly associated with lymphoproliferative disorders and a large number of human neoplasms, mainly undifferentiated nasopharyngeal carcinoma and Burkitt lymphoma. The viral DNA has been detected in other tumors, such as carcinomas from tonsil, salivary glands, and thymus, and malignancies of the female genital tract. Some authors have proposed that EBV could play a role in the carcinogenesis of cervical tumors; however, other studies do not support this hypothesis. Objective. - To assess whether EBV is associated with female genital tract neoplasms. Design. - Sixty-five biopsy specimens (5 in situ carcinomas, 24 invasive squamous cell carcinomas, 6 lymphoepithelioma-like carcinomas, and 30 endocervical adenocarcinomas) were used to perform EBV detection through RNA in situ hybridization. Results. - None of the cervical carcinoma cases studied was positive for EBV infection. Conclusions. - The results suggest that it is still premature to incriminate EBV in the carcinogenesis of cervical carcinoma. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-11-19 2022-04-28T19:54:50Z 2022-04-28T19:54:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Archives of Pathology and Laboratory Medicine, v. 123, n. 11, p. 1098-1100, 1999. 0003-9985 http://hdl.handle.net/11449/224118 2-s2.0-0032698009 |
identifier_str_mv |
Archives of Pathology and Laboratory Medicine, v. 123, n. 11, p. 1098-1100, 1999. 0003-9985 2-s2.0-0032698009 |
url |
http://hdl.handle.net/11449/224118 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Pathology and Laboratory Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1098-1100 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965166207500288 |