Association between vitamin D and malignant mammary tumors in obese female dogs
Main Author: | |
---|---|
Publication Date: | 2022 |
Other Authors: | , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.24070/bjvp.1983-0246.v15i1p20-30 http://hdl.handle.net/11449/241119 |
Summary: | Overweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was. |
id |
UNSP_857fff2fff2c4088bb06cb2cba311da7 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/241119 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Association between vitamin D and malignant mammary tumors in obese female dogsbody fatfemale dogshypovitaminosis Dmammary carcinomasOverweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was.Department of Animal Morphology and Physiology FCAV-UNESP, São Paulo StateDepartment of Pathology Theriogenology and One Health FCAV-UNESP, São Paulo StateDepartment of Veterinary Clinic and Surgery FCAV-UNESP, São Paulo StateDepartment of Engineering and Exact Sciences FCAV-UNESP, São Paulo StateDepartment of Animal Morphology and Physiology FCAV-UNESP, São Paulo StateDepartment of Pathology Theriogenology and One Health FCAV-UNESP, São Paulo StateDepartment of Veterinary Clinic and Surgery FCAV-UNESP, São Paulo StateDepartment of Engineering and Exact Sciences FCAV-UNESP, São Paulo StateUniversidade Estadual Paulista (UNESP)Do Nascimento-Hama, Lismara Castro [UNESP]de Oliveira Vasconcelos, Rosemeri [UNESP]De Nardi, Andrigo Barboza [UNESP]de Camargo, Ana Carolina de Andrade Leite [UNESP]Marchini, Larissa Rodrigues [UNESP]Rocha, Fabiana Del Lama [UNESP]Firmo, Bruna Fernanda [UNESP]Estrada, Cristhian Rene Vargas [UNESP]Artoni, Silvana Martinez Baraldi [UNESP]Nunes, Newton [UNESP]Panosso, Alan Rodrigo [UNESP]Amoroso, Lizandra [UNESP]2023-03-01T20:48:02Z2023-03-01T20:48:02Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20-30http://dx.doi.org/10.24070/bjvp.1983-0246.v15i1p20-30Brazilian Journal of Veterinary Pathology, v. 15, n. 1, p. 20-30, 2022.1983-0246http://hdl.handle.net/11449/24111910.24070/bjvp.1983-0246.v15i1p20-302-s2.0-85131457355Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Pathologyinfo:eu-repo/semantics/openAccess2023-03-01T20:48:02Zoai:repositorio.unesp.br:11449/241119Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:48:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association between vitamin D and malignant mammary tumors in obese female dogs |
title |
Association between vitamin D and malignant mammary tumors in obese female dogs |
spellingShingle |
Association between vitamin D and malignant mammary tumors in obese female dogs Do Nascimento-Hama, Lismara Castro [UNESP] body fat female dogs hypovitaminosis D mammary carcinomas |
title_short |
Association between vitamin D and malignant mammary tumors in obese female dogs |
title_full |
Association between vitamin D and malignant mammary tumors in obese female dogs |
title_fullStr |
Association between vitamin D and malignant mammary tumors in obese female dogs |
title_full_unstemmed |
Association between vitamin D and malignant mammary tumors in obese female dogs |
title_sort |
Association between vitamin D and malignant mammary tumors in obese female dogs |
author |
Do Nascimento-Hama, Lismara Castro [UNESP] |
author_facet |
Do Nascimento-Hama, Lismara Castro [UNESP] de Oliveira Vasconcelos, Rosemeri [UNESP] De Nardi, Andrigo Barboza [UNESP] de Camargo, Ana Carolina de Andrade Leite [UNESP] Marchini, Larissa Rodrigues [UNESP] Rocha, Fabiana Del Lama [UNESP] Firmo, Bruna Fernanda [UNESP] Estrada, Cristhian Rene Vargas [UNESP] Artoni, Silvana Martinez Baraldi [UNESP] Nunes, Newton [UNESP] Panosso, Alan Rodrigo [UNESP] Amoroso, Lizandra [UNESP] |
author_role |
author |
author2 |
de Oliveira Vasconcelos, Rosemeri [UNESP] De Nardi, Andrigo Barboza [UNESP] de Camargo, Ana Carolina de Andrade Leite [UNESP] Marchini, Larissa Rodrigues [UNESP] Rocha, Fabiana Del Lama [UNESP] Firmo, Bruna Fernanda [UNESP] Estrada, Cristhian Rene Vargas [UNESP] Artoni, Silvana Martinez Baraldi [UNESP] Nunes, Newton [UNESP] Panosso, Alan Rodrigo [UNESP] Amoroso, Lizandra [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Do Nascimento-Hama, Lismara Castro [UNESP] de Oliveira Vasconcelos, Rosemeri [UNESP] De Nardi, Andrigo Barboza [UNESP] de Camargo, Ana Carolina de Andrade Leite [UNESP] Marchini, Larissa Rodrigues [UNESP] Rocha, Fabiana Del Lama [UNESP] Firmo, Bruna Fernanda [UNESP] Estrada, Cristhian Rene Vargas [UNESP] Artoni, Silvana Martinez Baraldi [UNESP] Nunes, Newton [UNESP] Panosso, Alan Rodrigo [UNESP] Amoroso, Lizandra [UNESP] |
dc.subject.por.fl_str_mv |
body fat female dogs hypovitaminosis D mammary carcinomas |
topic |
body fat female dogs hypovitaminosis D mammary carcinomas |
description |
Overweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-01 2023-03-01T20:48:02Z 2023-03-01T20:48:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.24070/bjvp.1983-0246.v15i1p20-30 Brazilian Journal of Veterinary Pathology, v. 15, n. 1, p. 20-30, 2022. 1983-0246 http://hdl.handle.net/11449/241119 10.24070/bjvp.1983-0246.v15i1p20-30 2-s2.0-85131457355 |
url |
http://dx.doi.org/10.24070/bjvp.1983-0246.v15i1p20-30 http://hdl.handle.net/11449/241119 |
identifier_str_mv |
Brazilian Journal of Veterinary Pathology, v. 15, n. 1, p. 20-30, 2022. 1983-0246 10.24070/bjvp.1983-0246.v15i1p20-30 2-s2.0-85131457355 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
20-30 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965403190919168 |