Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1126/sciadv.aaq0800 http://hdl.handle.net/11449/170859 |
Resumo: | The present study has revealed that the lungfish has both structural and functional features of its system for physiological control of heart rate, previously considered solely mammalian, that together generate variability (HRV). Ultrastructural and electrophysiological investigation revealed that the nerves connecting the brain to the heart are myelinated, conferring rapid conduction velocities, comparable to mammalian fibers that generate instantaneous changes in heart rate at the onset of each air breath. These respiration-related changes in beat-to-beat cardiac intervals were detected by complex analysis of HRV and shown to maximize oxygen uptake per breath, a causal relationship never conclusively demonstrated in mammals. Cardiac vagal preganglionic neurons, responsible for controlling heart rate via the parasympathetic vagus nerve, were shown to have multiple locations, chiefly within the dorsal vagalmotor nucleus thatmay enable interactive control of the circulatory and respiratory systems, similar to that described for tetrapods. The present illustration of an apparently highly evolved control systemfor HRV in a fish with a proven ancient lineage, based on paleontological, morphological, and recent genetic evidence, questions much of the anthropocentric thinking implied by some mammalian physiologists and encouraged by many psychobiologists. It is possible that some characteristics of mammalian respiratory sinus arrhythmia, for which functional roles have been sought, are evolutionary relics that had their physiological role defined in ancient representatives of the vertebrates with undivided circulatory systems. |
id |
UNSP_85d257869de0530f74029310eaba62ba |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/170859 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfishThe present study has revealed that the lungfish has both structural and functional features of its system for physiological control of heart rate, previously considered solely mammalian, that together generate variability (HRV). Ultrastructural and electrophysiological investigation revealed that the nerves connecting the brain to the heart are myelinated, conferring rapid conduction velocities, comparable to mammalian fibers that generate instantaneous changes in heart rate at the onset of each air breath. These respiration-related changes in beat-to-beat cardiac intervals were detected by complex analysis of HRV and shown to maximize oxygen uptake per breath, a causal relationship never conclusively demonstrated in mammals. Cardiac vagal preganglionic neurons, responsible for controlling heart rate via the parasympathetic vagus nerve, were shown to have multiple locations, chiefly within the dorsal vagalmotor nucleus thatmay enable interactive control of the circulatory and respiratory systems, similar to that described for tetrapods. The present illustration of an apparently highly evolved control systemfor HRV in a fish with a proven ancient lineage, based on paleontological, morphological, and recent genetic evidence, questions much of the anthropocentric thinking implied by some mammalian physiologists and encouraged by many psychobiologists. It is possible that some characteristics of mammalian respiratory sinus arrhythmia, for which functional roles have been sought, are evolutionary relics that had their physiological role defined in ancient representatives of the vertebrates with undivided circulatory systems.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Physiological Sciences Federal University of São Carlos (UFSCar)National Institute of Science and Technology in Comparative Physiology (INCT FisComp)School of Biosciences University of BirminghamDepartment of Zoology São Paulo State University (UNESP)Institute of Biology Federal University of Bahia (UFBA)Department of Zoology São Paulo State University (UNESP)Universidade Federal de São Carlos (UFSCar)National Institute of Science and Technology in Comparative Physiology (INCT FisComp)University of BirminghamUniversidade Estadual Paulista (Unesp)Universidade Federal da Bahia (UFBA)Monteiro, Diana A.Taylor, Edwin W.Sartori, Marina R. [UNESP]Cruz, André L.Rantin, Francisco T.Leite, Cleo A. C.2018-12-11T16:52:42Z2018-12-11T16:52:42Z2018-02-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1126/sciadv.aaq0800Science Advances, v. 4, n. 2, 2018.2375-2548http://hdl.handle.net/11449/17085910.1126/sciadv.aaq08002-s2.0-850447784012-s2.0-85044778401.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScience Advances5,817info:eu-repo/semantics/openAccess2023-11-30T06:16:15Zoai:repositorio.unesp.br:11449/170859Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-30T06:16:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
title |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
spellingShingle |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish Monteiro, Diana A. |
title_short |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
title_full |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
title_fullStr |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
title_full_unstemmed |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
title_sort |
Cardiorespiratory interactions previously identified as mammalian are present in the primitive lungfish |
author |
Monteiro, Diana A. |
author_facet |
Monteiro, Diana A. Taylor, Edwin W. Sartori, Marina R. [UNESP] Cruz, André L. Rantin, Francisco T. Leite, Cleo A. C. |
author_role |
author |
author2 |
Taylor, Edwin W. Sartori, Marina R. [UNESP] Cruz, André L. Rantin, Francisco T. Leite, Cleo A. C. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) National Institute of Science and Technology in Comparative Physiology (INCT FisComp) University of Birmingham Universidade Estadual Paulista (Unesp) Universidade Federal da Bahia (UFBA) |
dc.contributor.author.fl_str_mv |
Monteiro, Diana A. Taylor, Edwin W. Sartori, Marina R. [UNESP] Cruz, André L. Rantin, Francisco T. Leite, Cleo A. C. |
description |
The present study has revealed that the lungfish has both structural and functional features of its system for physiological control of heart rate, previously considered solely mammalian, that together generate variability (HRV). Ultrastructural and electrophysiological investigation revealed that the nerves connecting the brain to the heart are myelinated, conferring rapid conduction velocities, comparable to mammalian fibers that generate instantaneous changes in heart rate at the onset of each air breath. These respiration-related changes in beat-to-beat cardiac intervals were detected by complex analysis of HRV and shown to maximize oxygen uptake per breath, a causal relationship never conclusively demonstrated in mammals. Cardiac vagal preganglionic neurons, responsible for controlling heart rate via the parasympathetic vagus nerve, were shown to have multiple locations, chiefly within the dorsal vagalmotor nucleus thatmay enable interactive control of the circulatory and respiratory systems, similar to that described for tetrapods. The present illustration of an apparently highly evolved control systemfor HRV in a fish with a proven ancient lineage, based on paleontological, morphological, and recent genetic evidence, questions much of the anthropocentric thinking implied by some mammalian physiologists and encouraged by many psychobiologists. It is possible that some characteristics of mammalian respiratory sinus arrhythmia, for which functional roles have been sought, are evolutionary relics that had their physiological role defined in ancient representatives of the vertebrates with undivided circulatory systems. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:52:42Z 2018-12-11T16:52:42Z 2018-02-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1126/sciadv.aaq0800 Science Advances, v. 4, n. 2, 2018. 2375-2548 http://hdl.handle.net/11449/170859 10.1126/sciadv.aaq0800 2-s2.0-85044778401 2-s2.0-85044778401.pdf |
url |
http://dx.doi.org/10.1126/sciadv.aaq0800 http://hdl.handle.net/11449/170859 |
identifier_str_mv |
Science Advances, v. 4, n. 2, 2018. 2375-2548 10.1126/sciadv.aaq0800 2-s2.0-85044778401 2-s2.0-85044778401.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Science Advances 5,817 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789861430689792 |