Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis

Detalhes bibliográficos
Autor(a) principal: Mendes-Giannini, Maria José Soares [UNESP]
Data de Publicação: 1989
Outros Autores: Bueno, J. P. [UNESP], Aparecida Shikanai-Yasuda, M. [UNESP], Ferreira, A. W. [UNESP], Masuda, A. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC267138/
http://hdl.handle.net/11449/63952
Resumo: The 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable afer 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.
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spelling Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosisfungus antigenglycoproteinimmunoglobulin gclinical articlefungushumanhuman cellimmunoblottingnonhumanparacoccidioides brasiliensispriority journalserumsouth american blastomycosisAntigens, FungalChromatography, AffinityElectrophoresis, Polyacrylamide GelGlycoproteinsHumanImmune SeraImmunoblottingMitosporic FungiMolecular WeightParacoccidioidesParacoccidioidomycosisSupport, Non-U.S. Gov'tTime FactorsFungiOryctolagus cuniculusParacoccidioides brasiliensisThe 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable afer 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.Dep. de Analises Clinicas Fac. de Ciencias Farmaceut. UNESP, AraraquaraDep. de Analises Clinicas Fac. de Ciencias Farmaceut. UNESP, AraraquaraUniversidade Estadual Paulista (Unesp)Mendes-Giannini, Maria José Soares [UNESP]Bueno, J. P. [UNESP]Aparecida Shikanai-Yasuda, M. [UNESP]Ferreira, A. W. [UNESP]Masuda, A. [UNESP]2014-05-27T07:35:52Z2014-05-27T07:35:52Z1989-12-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2842-2845application/pdfhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC267138/Journal of Clinical Microbiology, v. 27, n. 12, p. 2842-2845, 1989.0095-1137http://hdl.handle.net/11449/639522-s2.0-00243545152-s2.0-0024354515.pdf0000-0002-8059-0826Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Clinical Microbiology4.0542,256info:eu-repo/semantics/openAccess2023-11-16T06:07:34Zoai:repositorio.unesp.br:11449/63952Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-16T06:07:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
title Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
spellingShingle Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
Mendes-Giannini, Maria José Soares [UNESP]
fungus antigen
glycoprotein
immunoglobulin g
clinical article
fungus
human
human cell
immunoblotting
nonhuman
paracoccidioides brasiliensis
priority journal
serum
south american blastomycosis
Antigens, Fungal
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Glycoproteins
Human
Immune Sera
Immunoblotting
Mitosporic Fungi
Molecular Weight
Paracoccidioides
Paracoccidioidomycosis
Support, Non-U.S. Gov't
Time Factors
Fungi
Oryctolagus cuniculus
Paracoccidioides brasiliensis
title_short Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
title_full Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
title_fullStr Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
title_full_unstemmed Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
title_sort Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
author Mendes-Giannini, Maria José Soares [UNESP]
author_facet Mendes-Giannini, Maria José Soares [UNESP]
Bueno, J. P. [UNESP]
Aparecida Shikanai-Yasuda, M. [UNESP]
Ferreira, A. W. [UNESP]
Masuda, A. [UNESP]
author_role author
author2 Bueno, J. P. [UNESP]
Aparecida Shikanai-Yasuda, M. [UNESP]
Ferreira, A. W. [UNESP]
Masuda, A. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mendes-Giannini, Maria José Soares [UNESP]
Bueno, J. P. [UNESP]
Aparecida Shikanai-Yasuda, M. [UNESP]
Ferreira, A. W. [UNESP]
Masuda, A. [UNESP]
dc.subject.por.fl_str_mv fungus antigen
glycoprotein
immunoglobulin g
clinical article
fungus
human
human cell
immunoblotting
nonhuman
paracoccidioides brasiliensis
priority journal
serum
south american blastomycosis
Antigens, Fungal
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Glycoproteins
Human
Immune Sera
Immunoblotting
Mitosporic Fungi
Molecular Weight
Paracoccidioides
Paracoccidioidomycosis
Support, Non-U.S. Gov't
Time Factors
Fungi
Oryctolagus cuniculus
Paracoccidioides brasiliensis
topic fungus antigen
glycoprotein
immunoglobulin g
clinical article
fungus
human
human cell
immunoblotting
nonhuman
paracoccidioides brasiliensis
priority journal
serum
south american blastomycosis
Antigens, Fungal
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Glycoproteins
Human
Immune Sera
Immunoblotting
Mitosporic Fungi
Molecular Weight
Paracoccidioides
Paracoccidioidomycosis
Support, Non-U.S. Gov't
Time Factors
Fungi
Oryctolagus cuniculus
Paracoccidioides brasiliensis
description The 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable afer 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.
publishDate 1989
dc.date.none.fl_str_mv 1989-12-09
2014-05-27T07:35:52Z
2014-05-27T07:35:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ncbi.nlm.nih.gov/pmc/articles/PMC267138/
Journal of Clinical Microbiology, v. 27, n. 12, p. 2842-2845, 1989.
0095-1137
http://hdl.handle.net/11449/63952
2-s2.0-0024354515
2-s2.0-0024354515.pdf
0000-0002-8059-0826
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC267138/
http://hdl.handle.net/11449/63952
identifier_str_mv Journal of Clinical Microbiology, v. 27, n. 12, p. 2842-2845, 1989.
0095-1137
2-s2.0-0024354515
2-s2.0-0024354515.pdf
0000-0002-8059-0826
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Clinical Microbiology
4.054
2,256
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2842-2845
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797789719096983552

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