Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/144685 |
Resumo: | Introduction: Breast carcinoma is one of the leading causes of deaths in the world and its early diagnosis and treatment have an important impact in the clinic evolution. The Immunohistochemical (IHC) profile determines the prognosis of the carcinoma and which is the best therapy to be established. Authors suggest that scintimammography could help immunohistochemistry (IHC) in these prognosis definitions. Methods: This study included patients with invasive breast carcinoma who were diagnosed in the period of 2011- 2013 at the Hospital das Clinicas of the Medical School of Botucatu. In all of the cases, IHC exams were performed, determining the proliferative index (PI) and the classification. The association between both results and the scintimammography (SMG) findings were analyzed. Results: of the 310 patients with invasive breast carcinoma diagnosed in the period, 243 had their classification and PI defined by the IHC. Normal SMG is associated to low PI and to hormonal therapy responsive classifications. The patients with altered SMG have had more chances of having a PI greater or equal to 14%, with high accuracy, high positive predictive valor and high sensibility, and are significantly associated to hormonal therapy irresponsive forms. More intense alterations are associated with forms of poor prognosis. Conclusion: altered SMG in patients with histological diagnosis of invasive breast carcinoma indicate a worse prognosis, as well as normaly indicates the existence of tumor classification with better response to hormonal chemotherapy. These findings do not allow the replacement of the immunohistochemistry prognosis profile for the scintimammography in the treatment of this disease, but can guide the prognosis and responsiveness to drug. Key Words: invasive breast carcinoma; immunohistochemistry; scintimammography; radioisotope; nuclear medicine. |
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Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamáriosCorrelation of scintimammography with immunohistochemical classification of breast tumorsInvasive breast carcinomaImmunohistochemistryScintimammographyRadioisotopeNuclear medicineCarcinoma invasivo de mamaImuno-histoquímicaCintilografia mamáriaRadioisotopoMedicina nuclearIntroduction: Breast carcinoma is one of the leading causes of deaths in the world and its early diagnosis and treatment have an important impact in the clinic evolution. The Immunohistochemical (IHC) profile determines the prognosis of the carcinoma and which is the best therapy to be established. Authors suggest that scintimammography could help immunohistochemistry (IHC) in these prognosis definitions. Methods: This study included patients with invasive breast carcinoma who were diagnosed in the period of 2011- 2013 at the Hospital das Clinicas of the Medical School of Botucatu. In all of the cases, IHC exams were performed, determining the proliferative index (PI) and the classification. The association between both results and the scintimammography (SMG) findings were analyzed. Results: of the 310 patients with invasive breast carcinoma diagnosed in the period, 243 had their classification and PI defined by the IHC. Normal SMG is associated to low PI and to hormonal therapy responsive classifications. The patients with altered SMG have had more chances of having a PI greater or equal to 14%, with high accuracy, high positive predictive valor and high sensibility, and are significantly associated to hormonal therapy irresponsive forms. More intense alterations are associated with forms of poor prognosis. Conclusion: altered SMG in patients with histological diagnosis of invasive breast carcinoma indicate a worse prognosis, as well as normaly indicates the existence of tumor classification with better response to hormonal chemotherapy. These findings do not allow the replacement of the immunohistochemistry prognosis profile for the scintimammography in the treatment of this disease, but can guide the prognosis and responsiveness to drug. Key Words: invasive breast carcinoma; immunohistochemistry; scintimammography; radioisotope; nuclear medicine.Introdução: o carcinoma de mama é uma das principais causas de morte no mundo e seu diagnóstico e tratamento precoces tem importante impacto na evolução clínica. A classificação imunoistoquímica (IHQ) determina o prognóstico do carcinoma e qual a melhor forma terapêutica a ser instituída. Autores sugerem que a cintilografia mamária poderia auxiliar a IHQ nessas definições de prognóstico. Casuística e Métodos: este estudo incluiu pacientes portadoras de carcinoma invasivo da mama que tiveram seu diagnóstico no período de 2011 a 2013 no Hospital das Clínicas da Faculdade de Medicina de Botucatu. Em todos os casos foram feitos exames imunoistoquímicos, determinando o índice proliferativo (IP) e a classificação. Associação entre ambos e os achados da cintilografia mamária foram analisadas. Resultados: dos 310 pacientes com carcinoma invasivo de mama diagnosticados no período, 243 tiveram sua classificação e IP definidos pela IHQ. Cintilografia normal está associada a baixo IP e a classificações responsivas à hormonioterapia. As pacientes com cintilografia alterada tiveram mais chance de ter IP maior ou igual a 14%, com alta acurácia, alto valor preditivo positivo e alta sensibilidade, e estão significativamente associadas a formas irresponsivas ao tratamento hormonal. Alterações mais intensas associam-se com formas de pior prognóstico. Conclusão: cintilografia mamária alterada em pacientes com diagnóstico histológico de carcinoma invasivo de mama indicam um pior prognóstico, bem como a normalidade indica a existência de classificação tumoral com melhor resposta à quimioterapia hormonal. Esses achados não permitem que a cintilografia de mama substitua a realização do painel prognóstico imunoistoquímico no tratamento dessa doença, mas sim possa orientar o prognóstico e responsividade a droga. Palavras chaves: carcinoma invasivo de mama; imuno-histoquímica; cintilografia mamária; radioisotopo; medicina nuclear.Universidade Estadual Paulista (Unesp)Marques, Mariângela Esther Alencar [UNESP]Universidade Estadual Paulista (Unesp)Henriques, Luciana Gurgel da Trindade Meira [UNESP]2016-11-23T19:59:02Z2016-11-23T19:59:02Z2016-09-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/11449/14468500087596233004064056P57528116925519142porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-01-28T06:52:18Zoai:repositorio.unesp.br:11449/144685Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-28T06:52:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários Correlation of scintimammography with immunohistochemical classification of breast tumors |
title |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
spellingShingle |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários Henriques, Luciana Gurgel da Trindade Meira [UNESP] Invasive breast carcinoma Immunohistochemistry Scintimammography Radioisotope Nuclear medicine Carcinoma invasivo de mama Imuno-histoquímica Cintilografia mamária Radioisotopo Medicina nuclear |
title_short |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
title_full |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
title_fullStr |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
title_full_unstemmed |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
title_sort |
Correlação da cintilografia de mama com a classificação imunoistoquímica dos tumores mamários |
author |
Henriques, Luciana Gurgel da Trindade Meira [UNESP] |
author_facet |
Henriques, Luciana Gurgel da Trindade Meira [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Marques, Mariângela Esther Alencar [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Henriques, Luciana Gurgel da Trindade Meira [UNESP] |
dc.subject.por.fl_str_mv |
Invasive breast carcinoma Immunohistochemistry Scintimammography Radioisotope Nuclear medicine Carcinoma invasivo de mama Imuno-histoquímica Cintilografia mamária Radioisotopo Medicina nuclear |
topic |
Invasive breast carcinoma Immunohistochemistry Scintimammography Radioisotope Nuclear medicine Carcinoma invasivo de mama Imuno-histoquímica Cintilografia mamária Radioisotopo Medicina nuclear |
description |
Introduction: Breast carcinoma is one of the leading causes of deaths in the world and its early diagnosis and treatment have an important impact in the clinic evolution. The Immunohistochemical (IHC) profile determines the prognosis of the carcinoma and which is the best therapy to be established. Authors suggest that scintimammography could help immunohistochemistry (IHC) in these prognosis definitions. Methods: This study included patients with invasive breast carcinoma who were diagnosed in the period of 2011- 2013 at the Hospital das Clinicas of the Medical School of Botucatu. In all of the cases, IHC exams were performed, determining the proliferative index (PI) and the classification. The association between both results and the scintimammography (SMG) findings were analyzed. Results: of the 310 patients with invasive breast carcinoma diagnosed in the period, 243 had their classification and PI defined by the IHC. Normal SMG is associated to low PI and to hormonal therapy responsive classifications. The patients with altered SMG have had more chances of having a PI greater or equal to 14%, with high accuracy, high positive predictive valor and high sensibility, and are significantly associated to hormonal therapy irresponsive forms. More intense alterations are associated with forms of poor prognosis. Conclusion: altered SMG in patients with histological diagnosis of invasive breast carcinoma indicate a worse prognosis, as well as normaly indicates the existence of tumor classification with better response to hormonal chemotherapy. These findings do not allow the replacement of the immunohistochemistry prognosis profile for the scintimammography in the treatment of this disease, but can guide the prognosis and responsiveness to drug. Key Words: invasive breast carcinoma; immunohistochemistry; scintimammography; radioisotope; nuclear medicine. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-23T19:59:02Z 2016-11-23T19:59:02Z 2016-09-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/11449/144685 000875962 33004064056P5 7528116925519142 |
url |
http://hdl.handle.net/11449/144685 |
identifier_str_mv |
000875962 33004064056P5 7528116925519142 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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