Myelodysplastic syndromes (MDS): prognostic factors and scoring systems

Bibliographic Details
Main Author: Souto, Elizabeth Xisto [UNESP]
Publication Date: 1997
Other Authors: Chauffaile, Maria De Lourdes Lopes Ferrari [UNESP], Moncau, José Eduardo Cajado [UNESP], Niero-melo, Lígia [UNESP], Braga, Gisele Wally [UNESP], Silva, Maria Regina Regis [UNESP], Kerbauy, José [UNESP]
Format: Article
Language: eng
Source: Repositório Institucional da UNESP
Download full: http://dx.doi.org/10.1590/S1516-31801997000500005
http://hdl.handle.net/11449/211703
Summary: OBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.
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spelling Myelodysplastic syndromes (MDS): prognostic factors and scoring systemsMyelodysplastic syndromesPrognosisSurvivalOBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.OBJETIVO: Avaliar utilidades dos sistemas de escore de Cassano e Sanz e propor outro. DESENHO: Serie de Casos. LOCAL: Hospitais universitários: EPM-UNIFESP e Faculdade de Medicina de Botucatu. PARTICIPANTES: 59 pacientes diagnosticados entre 1979 e 1992. INTERVENÇÃO: Avaliação de parâmetros clínico-laboratoriais. MENSURAÇÃO: Comparação estatística, análise uni e multivariada e curva de sobrevida atuarial. RESULTADOS: O sistema de Cassano dividiu os pacientes em alto e baixo risco (p=0.0966) enquanto o de Sanz em alto, intermediário e baixo risco (p=0.0108). A análise univariada demonstrou que hemoglobina, contagem de GB, relação EM, aumento do fígado e % de blastos na medula (MO) eram estatisticamente significantes. A regressão multivariada demonstrou como sendo significantes a % de blastos da MO (p=0.004) e os níveis de Hb (p=0.050). O nosso sistema, considerando os parâmetros da análise univariada, dividiu os pacientes em alto, intermediário e baixo risco (p=0.0038). CONCLUSÕES: O sistema de Sanz foi mais prático que o de Cassano enquanto o nosso, demonstrou valor preditivo de sobrevida e uso fácil na prática clínica.Universidade Federal de São Paulo, Escola Paulista de MedicinaUniversidade Estadual PaulistaUniversidade Estadual PaulistaAssociação Paulista de Medicina - APMUniversidade Federal de São PauloUniversidade Estadual Paulista (Unesp)Souto, Elizabeth Xisto [UNESP]Chauffaile, Maria De Lourdes Lopes Ferrari [UNESP]Moncau, José Eduardo Cajado [UNESP]Niero-melo, Lígia [UNESP]Braga, Gisele Wally [UNESP]Silva, Maria Regina Regis [UNESP]Kerbauy, José [UNESP]2021-07-14T10:28:24Z2021-07-14T10:28:24Z1997-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1537-1541application/pdfhttp://dx.doi.org/10.1590/S1516-31801997000500005Sao Paulo Medical Journal. São Paulo, SP, Brazil: Associação Paulista de Medicina - APM, v. 115, n. 5, p. 1537-1541, 1997.1516-31801806-9460http://hdl.handle.net/11449/21170310.1590/S1516-31801997000500005S1516-31801997000500005S1516-31801997000500005.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSao Paulo Medical Journalinfo:eu-repo/semantics/openAccess2023-10-02T06:02:39Zoai:repositorio.unesp.br:11449/211703Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-02T06:02:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
title Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
spellingShingle Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
Souto, Elizabeth Xisto [UNESP]
Myelodysplastic syndromes
Prognosis
Survival
title_short Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
title_full Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
title_fullStr Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
title_full_unstemmed Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
title_sort Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
author Souto, Elizabeth Xisto [UNESP]
author_facet Souto, Elizabeth Xisto [UNESP]
Chauffaile, Maria De Lourdes Lopes Ferrari [UNESP]
Moncau, José Eduardo Cajado [UNESP]
Niero-melo, Lígia [UNESP]
Braga, Gisele Wally [UNESP]
Silva, Maria Regina Regis [UNESP]
Kerbauy, José [UNESP]
author_role author
author2 Chauffaile, Maria De Lourdes Lopes Ferrari [UNESP]
Moncau, José Eduardo Cajado [UNESP]
Niero-melo, Lígia [UNESP]
Braga, Gisele Wally [UNESP]
Silva, Maria Regina Regis [UNESP]
Kerbauy, José [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Souto, Elizabeth Xisto [UNESP]
Chauffaile, Maria De Lourdes Lopes Ferrari [UNESP]
Moncau, José Eduardo Cajado [UNESP]
Niero-melo, Lígia [UNESP]
Braga, Gisele Wally [UNESP]
Silva, Maria Regina Regis [UNESP]
Kerbauy, José [UNESP]
dc.subject.por.fl_str_mv Myelodysplastic syndromes
Prognosis
Survival
topic Myelodysplastic syndromes
Prognosis
Survival
description OBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.
publishDate 1997
dc.date.none.fl_str_mv 1997-10
2021-07-14T10:28:24Z
2021-07-14T10:28:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-31801997000500005
Sao Paulo Medical Journal. São Paulo, SP, Brazil: Associação Paulista de Medicina - APM, v. 115, n. 5, p. 1537-1541, 1997.
1516-3180
1806-9460
http://hdl.handle.net/11449/211703
10.1590/S1516-31801997000500005
S1516-31801997000500005
S1516-31801997000500005.pdf
url http://dx.doi.org/10.1590/S1516-31801997000500005
http://hdl.handle.net/11449/211703
identifier_str_mv Sao Paulo Medical Journal. São Paulo, SP, Brazil: Associação Paulista de Medicina - APM, v. 115, n. 5, p. 1537-1541, 1997.
1516-3180
1806-9460
10.1590/S1516-31801997000500005
S1516-31801997000500005
S1516-31801997000500005.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sao Paulo Medical Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1537-1541
application/pdf
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964399870410752

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