Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators

Detalhes bibliográficos
Autor(a) principal: Castro, Guilherme Vieira de
Data de Publicação: 2015
Outros Autores: Romero Rocha, Carlos Murilo, Sanches, Vitor Lacerda, Zana Ribeiro, Pedro H., Donate, Paulo Marcos, laurentiz, Rosangela da Silva de [UNESP], Polikarpov, Igor, Sairre, Mirela I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.17807/orbital.v7i3.739
http://hdl.handle.net/11449/160636
Resumo: Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.
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spelling Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulatorsthyroid hormonesnuclear receptorligandssynthesisThyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed ABC, Ctr Ciencias Nat & Humanas, Rua Santa Adelia 166, BR-09210170 Santo Andre, SP, BrazilUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, BrazilUniv Sao Paulo, Inst Fis Sao Carlos, Dept Fis & Informat, BR-13566590 Sao Carlos, SP, BrazilUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, BrazilUniv Federal Mato Grosso Sul, Dept QuimicaUniversidade Federal do ABC (UFABC)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Castro, Guilherme Vieira deRomero Rocha, Carlos MuriloSanches, Vitor LacerdaZana Ribeiro, Pedro H.Donate, Paulo Marcoslaurentiz, Rosangela da Silva de [UNESP]Polikarpov, IgorSairre, Mirela I.2018-11-26T16:05:25Z2018-11-26T16:05:25Z2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article282-291application/pdfhttp://dx.doi.org/10.17807/orbital.v7i3.739Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.1984-6428http://hdl.handle.net/11449/16063610.17807/orbital.v7i3.739WOS:000219762300011WOS000219762300011.pdf79898377279107590000-0002-5240-4870Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOrbital-the Electronic Journal Of Chemistryinfo:eu-repo/semantics/openAccess2023-11-02T06:12:57Zoai:repositorio.unesp.br:11449/160636Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-02T06:12:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
title Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
spellingShingle Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
Castro, Guilherme Vieira de
thyroid hormones
nuclear receptor
ligands
synthesis
title_short Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
title_full Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
title_fullStr Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
title_full_unstemmed Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
title_sort Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators
author Castro, Guilherme Vieira de
author_facet Castro, Guilherme Vieira de
Romero Rocha, Carlos Murilo
Sanches, Vitor Lacerda
Zana Ribeiro, Pedro H.
Donate, Paulo Marcos
laurentiz, Rosangela da Silva de [UNESP]
Polikarpov, Igor
Sairre, Mirela I.
author_role author
author2 Romero Rocha, Carlos Murilo
Sanches, Vitor Lacerda
Zana Ribeiro, Pedro H.
Donate, Paulo Marcos
laurentiz, Rosangela da Silva de [UNESP]
Polikarpov, Igor
Sairre, Mirela I.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do ABC (UFABC)
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Castro, Guilherme Vieira de
Romero Rocha, Carlos Murilo
Sanches, Vitor Lacerda
Zana Ribeiro, Pedro H.
Donate, Paulo Marcos
laurentiz, Rosangela da Silva de [UNESP]
Polikarpov, Igor
Sairre, Mirela I.
dc.subject.por.fl_str_mv thyroid hormones
nuclear receptor
ligands
synthesis
topic thyroid hormones
nuclear receptor
ligands
synthesis
description Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01
2018-11-26T16:05:25Z
2018-11-26T16:05:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.17807/orbital.v7i3.739
Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.
1984-6428
http://hdl.handle.net/11449/160636
10.17807/orbital.v7i3.739
WOS:000219762300011
WOS000219762300011.pdf
7989837727910759
0000-0002-5240-4870
url http://dx.doi.org/10.17807/orbital.v7i3.739
http://hdl.handle.net/11449/160636
identifier_str_mv Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.
1984-6428
10.17807/orbital.v7i3.739
WOS:000219762300011
WOS000219762300011.pdf
7989837727910759
0000-0002-5240-4870
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Orbital-the Electronic Journal Of Chemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 282-291
application/pdf
dc.publisher.none.fl_str_mv Univ Federal Mato Grosso Sul, Dept Quimica
publisher.none.fl_str_mv Univ Federal Mato Grosso Sul, Dept Quimica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964796090580992

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