Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/jbm.a.36996 http://hdl.handle.net/11449/198991 |
Resumo: | Over the past few years, several tridimensional synthetic bone grafts, known as scaffolds, are being developed to overcome the autologous grafts limitations. Among the materials used on the production of scaffolds, the 45S5 bioglass stands out due to its capacity of bonding to hard and soft tissues. Silver nanoparticles are well-known for their antimicrobial properties and their incorporation on the scaffold may promote its antimicrobial response, avoiding microorganism proliferation on the materials surface. This study proposes a simple way to coat 45S5 bioglass-based scaffolds with silver nanoparticles. The scaffolds were obtained by the sponge replication technique and the silver nanoparticles were incorporated by soaking under ultrasonic stirring. The antimicrobial activity of the scaffolds was analyzed against three different microbial strains: S. aureus, P. aeruginosa, and C. albicans. Due to the heat treatment during the scaffold production, the bioglass crystalized mainly in a sodium calcium silicate phase, forming a glass–ceramic scaffold. The silver nanoparticles were coated in a well-distributed manner throughout the scaffold, while avoiding their aggregation. The coated scaffold inhibited the growth of all the analyzed microorganism. Therefore, the use of ultrasonic stirring to coat the bioglass scaffold with silver nanoparticles showed to be an efficient way to promote its antimicrobial response. |
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Repositório Institucional da UNESP |
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Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity45S5 bioglassantimicrobial scaffoldsglass–ceramicsilver nanoparticlessponge replication techniqueOver the past few years, several tridimensional synthetic bone grafts, known as scaffolds, are being developed to overcome the autologous grafts limitations. Among the materials used on the production of scaffolds, the 45S5 bioglass stands out due to its capacity of bonding to hard and soft tissues. Silver nanoparticles are well-known for their antimicrobial properties and their incorporation on the scaffold may promote its antimicrobial response, avoiding microorganism proliferation on the materials surface. This study proposes a simple way to coat 45S5 bioglass-based scaffolds with silver nanoparticles. The scaffolds were obtained by the sponge replication technique and the silver nanoparticles were incorporated by soaking under ultrasonic stirring. The antimicrobial activity of the scaffolds was analyzed against three different microbial strains: S. aureus, P. aeruginosa, and C. albicans. Due to the heat treatment during the scaffold production, the bioglass crystalized mainly in a sodium calcium silicate phase, forming a glass–ceramic scaffold. The silver nanoparticles were coated in a well-distributed manner throughout the scaffold, while avoiding their aggregation. The coated scaffold inhibited the growth of all the analyzed microorganism. Therefore, the use of ultrasonic stirring to coat the bioglass scaffold with silver nanoparticles showed to be an efficient way to promote its antimicrobial response.Bioceramics Laboratory Science and Technology Institute UNIFESPNanomaterials and Nanotoxicology Laboratory Science and Technology Institute UNIFESPIFSPScience and Technology Institute UNESPPlasmas and Processes Laboratory ITAScience and Technology Institute UNESPUniversidade Federal de São Paulo (UNIFESP)IFSPUniversidade Estadual Paulista (Unesp)ITAOliveira, Rodrigo L. M. S.Barbosa, LucasHurtado, Carolina R.Ramos, Lucas de P. [UNESP]Montanheiro, Thaís L. A.Oliveira, Luciane D. [UNESP]Tada, Dayane B.Trichês, Eliandra de Sousa2020-12-12T01:27:42Z2020-12-12T01:27:42Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/jbm.a.36996Journal of Biomedical Materials Research - Part A.1552-49651549-3296http://hdl.handle.net/11449/19899110.1002/jbm.a.369962-s2.0-85086510320Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Biomedical Materials Research - Part Ainfo:eu-repo/semantics/openAccess2021-10-22T21:54:38Zoai:repositorio.unesp.br:11449/198991Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T21:54:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
title |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
spellingShingle |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity Oliveira, Rodrigo L. M. S. 45S5 bioglass antimicrobial scaffolds glass–ceramic silver nanoparticles sponge replication technique |
title_short |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
title_full |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
title_fullStr |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
title_full_unstemmed |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
title_sort |
Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity |
author |
Oliveira, Rodrigo L. M. S. |
author_facet |
Oliveira, Rodrigo L. M. S. Barbosa, Lucas Hurtado, Carolina R. Ramos, Lucas de P. [UNESP] Montanheiro, Thaís L. A. Oliveira, Luciane D. [UNESP] Tada, Dayane B. Trichês, Eliandra de Sousa |
author_role |
author |
author2 |
Barbosa, Lucas Hurtado, Carolina R. Ramos, Lucas de P. [UNESP] Montanheiro, Thaís L. A. Oliveira, Luciane D. [UNESP] Tada, Dayane B. Trichês, Eliandra de Sousa |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) IFSP Universidade Estadual Paulista (Unesp) ITA |
dc.contributor.author.fl_str_mv |
Oliveira, Rodrigo L. M. S. Barbosa, Lucas Hurtado, Carolina R. Ramos, Lucas de P. [UNESP] Montanheiro, Thaís L. A. Oliveira, Luciane D. [UNESP] Tada, Dayane B. Trichês, Eliandra de Sousa |
dc.subject.por.fl_str_mv |
45S5 bioglass antimicrobial scaffolds glass–ceramic silver nanoparticles sponge replication technique |
topic |
45S5 bioglass antimicrobial scaffolds glass–ceramic silver nanoparticles sponge replication technique |
description |
Over the past few years, several tridimensional synthetic bone grafts, known as scaffolds, are being developed to overcome the autologous grafts limitations. Among the materials used on the production of scaffolds, the 45S5 bioglass stands out due to its capacity of bonding to hard and soft tissues. Silver nanoparticles are well-known for their antimicrobial properties and their incorporation on the scaffold may promote its antimicrobial response, avoiding microorganism proliferation on the materials surface. This study proposes a simple way to coat 45S5 bioglass-based scaffolds with silver nanoparticles. The scaffolds were obtained by the sponge replication technique and the silver nanoparticles were incorporated by soaking under ultrasonic stirring. The antimicrobial activity of the scaffolds was analyzed against three different microbial strains: S. aureus, P. aeruginosa, and C. albicans. Due to the heat treatment during the scaffold production, the bioglass crystalized mainly in a sodium calcium silicate phase, forming a glass–ceramic scaffold. The silver nanoparticles were coated in a well-distributed manner throughout the scaffold, while avoiding their aggregation. The coated scaffold inhibited the growth of all the analyzed microorganism. Therefore, the use of ultrasonic stirring to coat the bioglass scaffold with silver nanoparticles showed to be an efficient way to promote its antimicrobial response. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:27:42Z 2020-12-12T01:27:42Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/jbm.a.36996 Journal of Biomedical Materials Research - Part A. 1552-4965 1549-3296 http://hdl.handle.net/11449/198991 10.1002/jbm.a.36996 2-s2.0-85086510320 |
url |
http://dx.doi.org/10.1002/jbm.a.36996 http://hdl.handle.net/11449/198991 |
identifier_str_mv |
Journal of Biomedical Materials Research - Part A. 1552-4965 1549-3296 10.1002/jbm.a.36996 2-s2.0-85086510320 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Biomedical Materials Research - Part A |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789403205074944 |