Placental model as an important tool to study maternal-fetal interface
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.reprotox.2022.06.005 http://hdl.handle.net/11449/240430 |
Resumo: | The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Normal development and function of the placenta is dependent on hormonal signaling pathways that make the placenta a target of endocrine disrupting chemical (EDC) action. Studies showing association between prenatal exposure, hormone disruption, and reproductive damage indicate that EDCs are developmentally toxic and can impact future generations. In this context, new placental models (trophoblast-derived cell lines, organotypic or 3D cell models, and physiologically based kinetic models) have been developed in order to create new approach methodology (NAM) to assess and even prevent such disastrous toxic harm in future generations. With the widespread discouragement of conducting animal studies, it has become irrefutable to develop in vitro models that can serve as a substitute for in vivo models. The goal of this review is to discuss the newest in vitro models to understand the maternal-fetal interface and predict placental development, physiology, and dysfunction generated by failures in molecular hormone control mechanisms, which, consequently, may change epigenetic programming to increase susceptibility to metabolic and other disorders in the offspring. We summarize the latest placental models for developmental toxicology studies, focusing mainly on three-dimensional (3D) culture models. |
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Placental model as an important tool to study maternal-fetal interfaceDevelopmental toxicityEndocrine disrupting chemicalsPregnancyThe placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Normal development and function of the placenta is dependent on hormonal signaling pathways that make the placenta a target of endocrine disrupting chemical (EDC) action. Studies showing association between prenatal exposure, hormone disruption, and reproductive damage indicate that EDCs are developmentally toxic and can impact future generations. In this context, new placental models (trophoblast-derived cell lines, organotypic or 3D cell models, and physiologically based kinetic models) have been developed in order to create new approach methodology (NAM) to assess and even prevent such disastrous toxic harm in future generations. With the widespread discouragement of conducting animal studies, it has become irrefutable to develop in vitro models that can serve as a substitute for in vivo models. The goal of this review is to discuss the newest in vitro models to understand the maternal-fetal interface and predict placental development, physiology, and dysfunction generated by failures in molecular hormone control mechanisms, which, consequently, may change epigenetic programming to increase susceptibility to metabolic and other disorders in the offspring. We summarize the latest placental models for developmental toxicology studies, focusing mainly on three-dimensional (3D) culture models.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Clinical Medicine Medical School São Paulo State University (UNESP), SPDepartment of Morphology Health Sciences Center Federal University of Espirito Santo (UFES), ESDepartment of Clinical Medicine Medical School São Paulo State University (UNESP), SPUniversidade Estadual Paulista (UNESP)Federal University of Espirito Santo (UFES)Gonçalves, Bianca M. [UNESP]Graceli, Jones B.Rocha, Paula B. da [UNESP]Tilli, Helena P. [UNESP]Vieira, Ester M. [UNESP]Sibio, Maria T. de [UNESP]Peghinelli, Vinícius V. [UNESP]Deprá, Igor C. [UNESP]Mathias, Lucas S. [UNESP]Olímpio, Regiane M.C. [UNESP]Belik, Virgínia C. [UNESP]Nogueira, Célia R. [UNESP]2023-03-01T20:16:53Z2023-03-01T20:16:53Z2022-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7-13http://dx.doi.org/10.1016/j.reprotox.2022.06.005Reproductive Toxicology, v. 112, p. 7-13.1873-17080890-6238http://hdl.handle.net/11449/24043010.1016/j.reprotox.2022.06.0052-s2.0-85133800905Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Toxicologyinfo:eu-repo/semantics/openAccess2023-03-01T20:16:53Zoai:repositorio.unesp.br:11449/240430Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:16:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Placental model as an important tool to study maternal-fetal interface |
title |
Placental model as an important tool to study maternal-fetal interface |
spellingShingle |
Placental model as an important tool to study maternal-fetal interface Gonçalves, Bianca M. [UNESP] Developmental toxicity Endocrine disrupting chemicals Pregnancy |
title_short |
Placental model as an important tool to study maternal-fetal interface |
title_full |
Placental model as an important tool to study maternal-fetal interface |
title_fullStr |
Placental model as an important tool to study maternal-fetal interface |
title_full_unstemmed |
Placental model as an important tool to study maternal-fetal interface |
title_sort |
Placental model as an important tool to study maternal-fetal interface |
author |
Gonçalves, Bianca M. [UNESP] |
author_facet |
Gonçalves, Bianca M. [UNESP] Graceli, Jones B. Rocha, Paula B. da [UNESP] Tilli, Helena P. [UNESP] Vieira, Ester M. [UNESP] Sibio, Maria T. de [UNESP] Peghinelli, Vinícius V. [UNESP] Deprá, Igor C. [UNESP] Mathias, Lucas S. [UNESP] Olímpio, Regiane M.C. [UNESP] Belik, Virgínia C. [UNESP] Nogueira, Célia R. [UNESP] |
author_role |
author |
author2 |
Graceli, Jones B. Rocha, Paula B. da [UNESP] Tilli, Helena P. [UNESP] Vieira, Ester M. [UNESP] Sibio, Maria T. de [UNESP] Peghinelli, Vinícius V. [UNESP] Deprá, Igor C. [UNESP] Mathias, Lucas S. [UNESP] Olímpio, Regiane M.C. [UNESP] Belik, Virgínia C. [UNESP] Nogueira, Célia R. [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Federal University of Espirito Santo (UFES) |
dc.contributor.author.fl_str_mv |
Gonçalves, Bianca M. [UNESP] Graceli, Jones B. Rocha, Paula B. da [UNESP] Tilli, Helena P. [UNESP] Vieira, Ester M. [UNESP] Sibio, Maria T. de [UNESP] Peghinelli, Vinícius V. [UNESP] Deprá, Igor C. [UNESP] Mathias, Lucas S. [UNESP] Olímpio, Regiane M.C. [UNESP] Belik, Virgínia C. [UNESP] Nogueira, Célia R. [UNESP] |
dc.subject.por.fl_str_mv |
Developmental toxicity Endocrine disrupting chemicals Pregnancy |
topic |
Developmental toxicity Endocrine disrupting chemicals Pregnancy |
description |
The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Normal development and function of the placenta is dependent on hormonal signaling pathways that make the placenta a target of endocrine disrupting chemical (EDC) action. Studies showing association between prenatal exposure, hormone disruption, and reproductive damage indicate that EDCs are developmentally toxic and can impact future generations. In this context, new placental models (trophoblast-derived cell lines, organotypic or 3D cell models, and physiologically based kinetic models) have been developed in order to create new approach methodology (NAM) to assess and even prevent such disastrous toxic harm in future generations. With the widespread discouragement of conducting animal studies, it has become irrefutable to develop in vitro models that can serve as a substitute for in vivo models. The goal of this review is to discuss the newest in vitro models to understand the maternal-fetal interface and predict placental development, physiology, and dysfunction generated by failures in molecular hormone control mechanisms, which, consequently, may change epigenetic programming to increase susceptibility to metabolic and other disorders in the offspring. We summarize the latest placental models for developmental toxicology studies, focusing mainly on three-dimensional (3D) culture models. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 2023-03-01T20:16:53Z 2023-03-01T20:16:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.reprotox.2022.06.005 Reproductive Toxicology, v. 112, p. 7-13. 1873-1708 0890-6238 http://hdl.handle.net/11449/240430 10.1016/j.reprotox.2022.06.005 2-s2.0-85133800905 |
url |
http://dx.doi.org/10.1016/j.reprotox.2022.06.005 http://hdl.handle.net/11449/240430 |
identifier_str_mv |
Reproductive Toxicology, v. 112, p. 7-13. 1873-1708 0890-6238 10.1016/j.reprotox.2022.06.005 2-s2.0-85133800905 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproductive Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7-13 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965604840472576 |