Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1365-3083.2009.02260.x http://hdl.handle.net/11449/42495 |
Resumo: | To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H(2)O(2)), nitric oxide and TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H(2)O(2), TNF-alpha levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H(2)O(2) and TNF-alpha that was paired with the dissemination of C. albicans. These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections. |
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Influence of Tumour Condition on the Macrophage Activity in Candida albicans InfectionTo better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H(2)O(2)), nitric oxide and TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H(2)O(2), TNF-alpha levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H(2)O(2) and TNF-alpha that was paired with the dissemination of C. albicans. These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections.Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State Univ UNESP, Dept Biol Sci, Coll Sci, Expt Immunopathol Lab, BR-17033360 São Paulo, BrazilSão Paulo State Univ UNESP, Botucatu Med Sch, BR-17033360 São Paulo, BrazilHosp Estadual Bauru, São Paulo, BrazilInst Lauro de Souza Lima, São Paulo, BrazilSão Paulo State Univ UNESP, Dept Biol Sci, Coll Sci, Expt Immunopathol Lab, BR-17033360 São Paulo, BrazilSão Paulo State Univ UNESP, Botucatu Med Sch, BR-17033360 São Paulo, BrazilWiley-Blackwell Publishing, IncUniversidade Estadual Paulista (Unesp)Hosp Estadual BauruInstituto Lauro de Souza Lima (ILSL)Venturini, J. [UNESP]de Camargo, M. R. [UNESP]Felix, M. C.Vilani-Moreno, F. R.Arruda, Maria Sueli Parreira de [UNESP]2014-05-20T15:34:18Z2014-05-20T15:34:18Z2009-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleout/17application/pdfhttp://dx.doi.org/10.1111/j.1365-3083.2009.02260.xScandinavian Journal of Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 70, n. 1, p. 10-17, 2009.0300-9475http://hdl.handle.net/11449/4249510.1111/j.1365-3083.2009.02260.xWOS:000266844600002WOS000266844600002.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScandinavian Journal of Immunology2.3140,891info:eu-repo/semantics/openAccess2024-04-23T15:24:03Zoai:repositorio.unesp.br:11449/42495Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-23T15:24:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
title |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
spellingShingle |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection Venturini, J. [UNESP] |
title_short |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
title_full |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
title_fullStr |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
title_full_unstemmed |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
title_sort |
Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection |
author |
Venturini, J. [UNESP] |
author_facet |
Venturini, J. [UNESP] de Camargo, M. R. [UNESP] Felix, M. C. Vilani-Moreno, F. R. Arruda, Maria Sueli Parreira de [UNESP] |
author_role |
author |
author2 |
de Camargo, M. R. [UNESP] Felix, M. C. Vilani-Moreno, F. R. Arruda, Maria Sueli Parreira de [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Hosp Estadual Bauru Instituto Lauro de Souza Lima (ILSL) |
dc.contributor.author.fl_str_mv |
Venturini, J. [UNESP] de Camargo, M. R. [UNESP] Felix, M. C. Vilani-Moreno, F. R. Arruda, Maria Sueli Parreira de [UNESP] |
description |
To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H(2)O(2)), nitric oxide and TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H(2)O(2), TNF-alpha levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H(2)O(2) and TNF-alpha that was paired with the dissemination of C. albicans. These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-01 2014-05-20T15:34:18Z 2014-05-20T15:34:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1365-3083.2009.02260.x Scandinavian Journal of Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 70, n. 1, p. 10-17, 2009. 0300-9475 http://hdl.handle.net/11449/42495 10.1111/j.1365-3083.2009.02260.x WOS:000266844600002 WOS000266844600002.pdf |
url |
http://dx.doi.org/10.1111/j.1365-3083.2009.02260.x http://hdl.handle.net/11449/42495 |
identifier_str_mv |
Scandinavian Journal of Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 70, n. 1, p. 10-17, 2009. 0300-9475 10.1111/j.1365-3083.2009.02260.x WOS:000266844600002 WOS000266844600002.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scandinavian Journal of Immunology 2.314 0,891 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
out/17 application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley-Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965756178300928 |