Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/antiox8080276 http://hdl.handle.net/11449/190582 |
Resumo: | Background: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on NAFLD related to the obesity induced by a hypercaloric diet. Methods: Wistar rats were distributed in two groups: Control (Co, n = 12) and hypercaloric (Ob, n = 12). After 20 weeks, the animals were redistributed into the control group (Co, n = 6), control group supplemented with lycopene (Co+Ly, n = 6), obese group (Ob, n = 6), and obese group supplemented with lycopene (Ob+Ly, n = 6). Ob groups also received water + sucrose (25%). Animals received lycopene solution (10 mg/kg/day) or vehicle (corn oil) via gavage for 10 weeks. Results: Animals which consumed the hypercaloric diet had higher adiposity index, increased fasting blood glucose, hepatic and blood triglycerides, and also presented in the liver macro and microvesicular steatosis, besides elevated levels of tumor necrosis factor-α (TNF-α). Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-α, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity. Conclusion: Lycopene shows therapeutic potential to NAFLD. |
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Repositório Institucional da UNESP |
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Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese ratsHypercaloric dietMetabolic syndromeNAFLDObesityBackground: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on NAFLD related to the obesity induced by a hypercaloric diet. Methods: Wistar rats were distributed in two groups: Control (Co, n = 12) and hypercaloric (Ob, n = 12). After 20 weeks, the animals were redistributed into the control group (Co, n = 6), control group supplemented with lycopene (Co+Ly, n = 6), obese group (Ob, n = 6), and obese group supplemented with lycopene (Ob+Ly, n = 6). Ob groups also received water + sucrose (25%). Animals received lycopene solution (10 mg/kg/day) or vehicle (corn oil) via gavage for 10 weeks. Results: Animals which consumed the hypercaloric diet had higher adiposity index, increased fasting blood glucose, hepatic and blood triglycerides, and also presented in the liver macro and microvesicular steatosis, besides elevated levels of tumor necrosis factor-α (TNF-α). Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-α, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity. Conclusion: Lycopene shows therapeutic potential to NAFLD.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Medical School São Paulo State University (Unesp)School of Dentistry São Paulo State University (Unesp)Medical School São Paulo State University (Unesp)School of Dentistry São Paulo State University (Unesp)CNPq: 42.42.09/2016-0Universidade Estadual Paulista (Unesp)Costa, Mariane Róvero [UNESP]Garcia, Jéssica Leite [UNESP]Silva, Carol Cristina Vágula de Almeida [UNESP]Ferron, Artur Junio Togneri [UNESP]Francisqueti-Ferron, Fabiane Valentini [UNESP]Hasimoto, Fabiana Kurokawa [UNESP]Gregolin, Cristina Schmitt [UNESP]de Campos, Dijon Henrique Salomé [UNESP]de Andrade, Cleverton Roberto [UNESP]Ferreira, Ana Lúcia Dos Anjos [UNESP]Corrêa, Camila Renata [UNESP]Moreto, Fernando [UNESP]2019-10-06T17:18:07Z2019-10-06T17:18:07Z2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/antiox8080276Antioxidants, v. 8, n. 8, 2019.2076-3921http://hdl.handle.net/11449/19058210.3390/antiox80802762-s2.0-8507081997424026829697768750000-0001-7015-7175Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAntioxidantsinfo:eu-repo/semantics/openAccess2022-02-11T15:38:34Zoai:repositorio.unesp.br:11449/190582Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-02-11T15:38:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
title |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
spellingShingle |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats Costa, Mariane Róvero [UNESP] Hypercaloric diet Metabolic syndrome NAFLD Obesity |
title_short |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
title_full |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
title_fullStr |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
title_full_unstemmed |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
title_sort |
Lycopene modulates pathophysiological processes of non-alcoholic fatty liver disease in obese rats |
author |
Costa, Mariane Róvero [UNESP] |
author_facet |
Costa, Mariane Róvero [UNESP] Garcia, Jéssica Leite [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Ferron, Artur Junio Togneri [UNESP] Francisqueti-Ferron, Fabiane Valentini [UNESP] Hasimoto, Fabiana Kurokawa [UNESP] Gregolin, Cristina Schmitt [UNESP] de Campos, Dijon Henrique Salomé [UNESP] de Andrade, Cleverton Roberto [UNESP] Ferreira, Ana Lúcia Dos Anjos [UNESP] Corrêa, Camila Renata [UNESP] Moreto, Fernando [UNESP] |
author_role |
author |
author2 |
Garcia, Jéssica Leite [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Ferron, Artur Junio Togneri [UNESP] Francisqueti-Ferron, Fabiane Valentini [UNESP] Hasimoto, Fabiana Kurokawa [UNESP] Gregolin, Cristina Schmitt [UNESP] de Campos, Dijon Henrique Salomé [UNESP] de Andrade, Cleverton Roberto [UNESP] Ferreira, Ana Lúcia Dos Anjos [UNESP] Corrêa, Camila Renata [UNESP] Moreto, Fernando [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Costa, Mariane Róvero [UNESP] Garcia, Jéssica Leite [UNESP] Silva, Carol Cristina Vágula de Almeida [UNESP] Ferron, Artur Junio Togneri [UNESP] Francisqueti-Ferron, Fabiane Valentini [UNESP] Hasimoto, Fabiana Kurokawa [UNESP] Gregolin, Cristina Schmitt [UNESP] de Campos, Dijon Henrique Salomé [UNESP] de Andrade, Cleverton Roberto [UNESP] Ferreira, Ana Lúcia Dos Anjos [UNESP] Corrêa, Camila Renata [UNESP] Moreto, Fernando [UNESP] |
dc.subject.por.fl_str_mv |
Hypercaloric diet Metabolic syndrome NAFLD Obesity |
topic |
Hypercaloric diet Metabolic syndrome NAFLD Obesity |
description |
Background: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on NAFLD related to the obesity induced by a hypercaloric diet. Methods: Wistar rats were distributed in two groups: Control (Co, n = 12) and hypercaloric (Ob, n = 12). After 20 weeks, the animals were redistributed into the control group (Co, n = 6), control group supplemented with lycopene (Co+Ly, n = 6), obese group (Ob, n = 6), and obese group supplemented with lycopene (Ob+Ly, n = 6). Ob groups also received water + sucrose (25%). Animals received lycopene solution (10 mg/kg/day) or vehicle (corn oil) via gavage for 10 weeks. Results: Animals which consumed the hypercaloric diet had higher adiposity index, increased fasting blood glucose, hepatic and blood triglycerides, and also presented in the liver macro and microvesicular steatosis, besides elevated levels of tumor necrosis factor-α (TNF-α). Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-α, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity. Conclusion: Lycopene shows therapeutic potential to NAFLD. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:18:07Z 2019-10-06T17:18:07Z 2019-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/antiox8080276 Antioxidants, v. 8, n. 8, 2019. 2076-3921 http://hdl.handle.net/11449/190582 10.3390/antiox8080276 2-s2.0-85070819974 2402682969776875 0000-0001-7015-7175 |
url |
http://dx.doi.org/10.3390/antiox8080276 http://hdl.handle.net/11449/190582 |
identifier_str_mv |
Antioxidants, v. 8, n. 8, 2019. 2076-3921 10.3390/antiox8080276 2-s2.0-85070819974 2402682969776875 0000-0001-7015-7175 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Antioxidants |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965149599105024 |