Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-021-04166-2 http://hdl.handle.net/11449/233519 |
Resumo: | Objectives: To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. Materials and methods: Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used. Results: No differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I. Conclusions: All restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. Clinical relevance The different restorative techniques are equally successful in NCCLs after 2 years of clinical functioning and have similar effects on MMPs present in crevicular fluid. |
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Repositório Institucional da UNESP |
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Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluidClinical trialGingival crevicular fluidGlass-ionomer cementMatrix metalloproteinasesNon-carious cervical lesionsResin compositeObjectives: To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. Materials and methods: Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used. Results: No differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I. Conclusions: All restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. Clinical relevance The different restorative techniques are equally successful in NCCLs after 2 years of clinical functioning and have similar effects on MMPs present in crevicular fluid.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Araçatuba School of Dentistry São Paulo State University, José Bonifácio St, 1193, SPOregon Health and Science University, SW Sam Jackson Park Rd, OR 97239Bauru School of Dentistry University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla St., 9-75 - Jardim Brasil, SPAraçatuba School of Dentistry São Paulo State University, José Bonifácio St, 1193, SPFAPESP: 2014/07086-0CNPq: 447616/2014-5Universidade Estadual Paulista (UNESP)Oregon Health and Science UniversityUniversidade de São Paulo (USP)Gonçalves, Rafael Simões [UNESP]Scaffa, Polliana Mendes CandiaShinohara, Mirela Sanae [UNESP]de Andrade Carvalho, Paulo Roberto Marão [UNESP]Buzalaf, Marília Afonso RabeloFagundes, Ticiane Cestari [UNESP]2022-05-01T09:00:54Z2022-05-01T09:00:54Z2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1889-1902http://dx.doi.org/10.1007/s00784-021-04166-2Clinical Oral Investigations, v. 26, n. 2, p. 1889-1902, 2022.1436-37711432-6981http://hdl.handle.net/11449/23351910.1007/s00784-021-04166-22-s2.0-85114681979Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigationsinfo:eu-repo/semantics/openAccess2022-05-01T09:00:54Zoai:repositorio.unesp.br:11449/233519Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T09:00:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
title |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
spellingShingle |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid Gonçalves, Rafael Simões [UNESP] Clinical trial Gingival crevicular fluid Glass-ionomer cement Matrix metalloproteinases Non-carious cervical lesions Resin composite |
title_short |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
title_full |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
title_fullStr |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
title_full_unstemmed |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
title_sort |
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid |
author |
Gonçalves, Rafael Simões [UNESP] |
author_facet |
Gonçalves, Rafael Simões [UNESP] Scaffa, Polliana Mendes Candia Shinohara, Mirela Sanae [UNESP] de Andrade Carvalho, Paulo Roberto Marão [UNESP] Buzalaf, Marília Afonso Rabelo Fagundes, Ticiane Cestari [UNESP] |
author_role |
author |
author2 |
Scaffa, Polliana Mendes Candia Shinohara, Mirela Sanae [UNESP] de Andrade Carvalho, Paulo Roberto Marão [UNESP] Buzalaf, Marília Afonso Rabelo Fagundes, Ticiane Cestari [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Oregon Health and Science University Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Gonçalves, Rafael Simões [UNESP] Scaffa, Polliana Mendes Candia Shinohara, Mirela Sanae [UNESP] de Andrade Carvalho, Paulo Roberto Marão [UNESP] Buzalaf, Marília Afonso Rabelo Fagundes, Ticiane Cestari [UNESP] |
dc.subject.por.fl_str_mv |
Clinical trial Gingival crevicular fluid Glass-ionomer cement Matrix metalloproteinases Non-carious cervical lesions Resin composite |
topic |
Clinical trial Gingival crevicular fluid Glass-ionomer cement Matrix metalloproteinases Non-carious cervical lesions Resin composite |
description |
Objectives: To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. Materials and methods: Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used. Results: No differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I. Conclusions: All restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. Clinical relevance The different restorative techniques are equally successful in NCCLs after 2 years of clinical functioning and have similar effects on MMPs present in crevicular fluid. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T09:00:54Z 2022-05-01T09:00:54Z 2022-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-021-04166-2 Clinical Oral Investigations, v. 26, n. 2, p. 1889-1902, 2022. 1436-3771 1432-6981 http://hdl.handle.net/11449/233519 10.1007/s00784-021-04166-2 2-s2.0-85114681979 |
url |
http://dx.doi.org/10.1007/s00784-021-04166-2 http://hdl.handle.net/11449/233519 |
identifier_str_mv |
Clinical Oral Investigations, v. 26, n. 2, p. 1889-1902, 2022. 1436-3771 1432-6981 10.1007/s00784-021-04166-2 2-s2.0-85114681979 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1889-1902 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964908634243072 |