Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.actatropica.2011.10.009 http://hdl.handle.net/11449/42629 |
Resumo: | We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved. |
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Repositório Institucional da UNESP |
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Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivaxPlasmodium vivaxHLA-DRB1Antibody responseWe evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)COLCIENCIASMinistry of Social ProtectionNational Institute of Allergy and Infectious Diseases (NIAID)Univ Fed Sergipe, Dept Biociencias, BR-49500000 Itabaiana, SE, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, BR-15090000 São Paulo, BrazilUniv Fed Triangulo Mineiro, Inst Ciencias Exatas Nat & Educ, BR-38025180 Uberaba, MC, BrazilUniv Estadual Paulista, BR-15054000 São Paulo, BrazilNucleo Estadual Amapa CRDT, Minist Saude, BR-68900430 Macapa, Amapa, BrazilSecretaria Vigilancia Saude, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria, BR-6703000 Ananindeua, Para, BrazilUniv São Paulo, Fac Ciencias Farmaceut, BR-05508900 São Paulo, BrazilFundação Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Malaria, BR-30190002 Belo Horizonte, MG, BrazilUniv Valle, Fac Salud, Inst Inmunol, Cali, ColombiaUniv Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, BR-24210130 Rio de Janeiro, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Epidemiol, BR-15090000 São Paulo, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Lab Imunohematol, BR-15090000 São Paulo, BrazilUniv Estadual Paulista, BR-15054000 São Paulo, BrazilFAPESP: 02/09546-1FAPESP: 06/09546-1CNPq: 302353/03-8CNPq: 410405/2006-0COLCIENCIAS: 1106-04-16489)Ministry of Social Protection: 2304-04-19524Ministry of Social Protection: 253-2005National Institute of Allergy and Infectious Diseases (NIAID): 49486/TMRCElsevier B.V.Universidade Federal de Sergipe (UFS)Faculdade de Medicina de São José do Rio Preto (FAMERP)Universidade Federal do Triângulo Mineiro (UFTM)Universidade Estadual Paulista (Unesp)Nucleo Estadual Amapa CRDTSecretaria Vigilancia SaudeUniversidade de São Paulo (USP)Fundação Oswaldo CruzUniv ValleUniversidade Federal Fluminense (UFF)Storti-Melo, Luciane MorenoCosta, Daniela Reis daSouza-Neiras, Wanessa ChristinaCassiano, Gustavo Capatti [UNESP]D'Almeida Couto, Vanja Suely CalvosaPovoa, Marinete MarinsSoares, Irene da SilvaCarvalho, Luzia Helena deArevalo-Herrera, MyrianHerrera, SocratesBaptista Rossit, Andrea ReginaCordeiro, Jose AntonioMattos, Luiz Carlos deMachado, Ricardo Luiz Dantas2014-05-20T15:34:42Z2014-05-20T15:34:42Z2012-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article152-155application/pdfhttp://dx.doi.org/10.1016/j.actatropica.2011.10.009Acta Tropica. Amsterdam: Elsevier B.V., v. 121, n. 2, p. 152-155, 2012.0001-706Xhttp://hdl.handle.net/11449/4262910.1016/j.actatropica.2011.10.009WOS:000300132800014WOS000300132800014.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Tropica2.509info:eu-repo/semantics/openAccess2023-11-15T06:13:34Zoai:repositorio.unesp.br:11449/42629Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-15T06:13:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
title |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
spellingShingle |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax Storti-Melo, Luciane Moreno Plasmodium vivax HLA-DRB1 Antibody response |
title_short |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
title_full |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
title_fullStr |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
title_full_unstemmed |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
title_sort |
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
author |
Storti-Melo, Luciane Moreno |
author_facet |
Storti-Melo, Luciane Moreno Costa, Daniela Reis da Souza-Neiras, Wanessa Christina Cassiano, Gustavo Capatti [UNESP] D'Almeida Couto, Vanja Suely Calvosa Povoa, Marinete Marins Soares, Irene da Silva Carvalho, Luzia Helena de Arevalo-Herrera, Myrian Herrera, Socrates Baptista Rossit, Andrea Regina Cordeiro, Jose Antonio Mattos, Luiz Carlos de Machado, Ricardo Luiz Dantas |
author_role |
author |
author2 |
Costa, Daniela Reis da Souza-Neiras, Wanessa Christina Cassiano, Gustavo Capatti [UNESP] D'Almeida Couto, Vanja Suely Calvosa Povoa, Marinete Marins Soares, Irene da Silva Carvalho, Luzia Helena de Arevalo-Herrera, Myrian Herrera, Socrates Baptista Rossit, Andrea Regina Cordeiro, Jose Antonio Mattos, Luiz Carlos de Machado, Ricardo Luiz Dantas |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Faculdade de Medicina de São José do Rio Preto (FAMERP) Universidade Federal do Triângulo Mineiro (UFTM) Universidade Estadual Paulista (Unesp) Nucleo Estadual Amapa CRDT Secretaria Vigilancia Saude Universidade de São Paulo (USP) Fundação Oswaldo Cruz Univ Valle Universidade Federal Fluminense (UFF) |
dc.contributor.author.fl_str_mv |
Storti-Melo, Luciane Moreno Costa, Daniela Reis da Souza-Neiras, Wanessa Christina Cassiano, Gustavo Capatti [UNESP] D'Almeida Couto, Vanja Suely Calvosa Povoa, Marinete Marins Soares, Irene da Silva Carvalho, Luzia Helena de Arevalo-Herrera, Myrian Herrera, Socrates Baptista Rossit, Andrea Regina Cordeiro, Jose Antonio Mattos, Luiz Carlos de Machado, Ricardo Luiz Dantas |
dc.subject.por.fl_str_mv |
Plasmodium vivax HLA-DRB1 Antibody response |
topic |
Plasmodium vivax HLA-DRB1 Antibody response |
description |
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 2014-05-20T15:34:42Z 2014-05-20T15:34:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.actatropica.2011.10.009 Acta Tropica. Amsterdam: Elsevier B.V., v. 121, n. 2, p. 152-155, 2012. 0001-706X http://hdl.handle.net/11449/42629 10.1016/j.actatropica.2011.10.009 WOS:000300132800014 WOS000300132800014.pdf |
url |
http://dx.doi.org/10.1016/j.actatropica.2011.10.009 http://hdl.handle.net/11449/42629 |
identifier_str_mv |
Acta Tropica. Amsterdam: Elsevier B.V., v. 121, n. 2, p. 152-155, 2012. 0001-706X 10.1016/j.actatropica.2011.10.009 WOS:000300132800014 WOS000300132800014.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Tropica 2.509 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
152-155 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964943302262784 |