TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.msec.2020.111735 http://hdl.handle.net/11449/210033 |
Resumo: | One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants. |
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TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralizationSrMicro-arc oxidationTiO2Orthopedics implantsOne of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants.FCTCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Minho, CMEMS UMinho Ctr MicroElectroMech Syst, Guimaraes, PortugalUniv Porto, Fac Engn, DEMM Dept Met & Mat Engn, Porto, PortugalUniv Grande Rio, Postgrad Program Translat Biomed, Duque De Caxias, RJ, BrazilSao Paulo State Univ, Inst Biomat Tribocorros & Nanomed, Brazilian Branch, IBTN Br, Bauru, SP, BrazilSao Paulo State Univ, Postgrad Program Mat Sci & Technol, Bauru, SP, BrazilCBPF Brazilian Ctr Res Phys, Rio De Janeiro, BrazilNatl Inst Metrol Qual & Technol, Directory Life Sci Appl Metrol, Xerem, RJ, BrazilNatl Inst Metrol Qual & Technol, Postgrad Program Biotechnol, Xerem, RJ, BrazilSao Paulo State Univ, Fac Sci, Dept Phys, Bauru, SP, BrazilUniv Minho, DEM Dept Mech Engn, Guimaraes, PortugalUniv Minho, 3Bs Res Grp, Res Inst Biomat Biodegradables & Biomimet, Guimaraes, PortugalUniv Minho, European Inst Excellence Tissue Engn & Regenerat, Guimaraes, PortugalSao Paulo State Univ, Inst Biomat Tribocorros & Nanomed, Brazilian Branch, IBTN Br, Bauru, SP, BrazilSao Paulo State Univ, Postgrad Program Mat Sci & Technol, Bauru, SP, BrazilSao Paulo State Univ, Fac Sci, Dept Phys, Bauru, SP, BrazilFCT: UID/EEA/04436/2019FCT: M-ERA-NET/0001/2015CAPES: 4.4.1.00FAPESP: 2017/24300-4: NORTE-08-5369-FSE-000051Elsevier B.V.Univ MinhoUniv PortoUniv Grande RioUniversidade Estadual Paulista (Unesp)CBPF Brazilian Ctr Res PhysNatl Inst Metrol Qual & TechnolCosta, A.Gemini-Piperni, S. [UNESP]Alves, A. C.Costa, N. A. [UNESP]Checca, N. R.Leite, P. E.Rocha, L. A. [UNESP]Pinto, A. M. P.Toptan, F. [UNESP]Rossi, A. L.Ribeiro, A. R. [UNESP]2021-06-25T12:37:26Z2021-06-25T12:37:26Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11http://dx.doi.org/10.1016/j.msec.2020.111735Materials Science & Engineering C-materials For Biological Applications. Amsterdam: Elsevier, v. 120, 11 p., 2021.0928-4931http://hdl.handle.net/11449/21003310.1016/j.msec.2020.111735WOS:000617983800004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science & Engineering C-materials For Biological Applicationsinfo:eu-repo/semantics/openAccess2024-04-25T17:39:39Zoai:repositorio.unesp.br:11449/210033Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-25T17:39:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
title |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
spellingShingle |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization Costa, A. Sr Micro-arc oxidation TiO2 Orthopedics implants |
title_short |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
title_full |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
title_fullStr |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
title_full_unstemmed |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
title_sort |
TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization |
author |
Costa, A. |
author_facet |
Costa, A. Gemini-Piperni, S. [UNESP] Alves, A. C. Costa, N. A. [UNESP] Checca, N. R. Leite, P. E. Rocha, L. A. [UNESP] Pinto, A. M. P. Toptan, F. [UNESP] Rossi, A. L. Ribeiro, A. R. [UNESP] |
author_role |
author |
author2 |
Gemini-Piperni, S. [UNESP] Alves, A. C. Costa, N. A. [UNESP] Checca, N. R. Leite, P. E. Rocha, L. A. [UNESP] Pinto, A. M. P. Toptan, F. [UNESP] Rossi, A. L. Ribeiro, A. R. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Minho Univ Porto Univ Grande Rio Universidade Estadual Paulista (Unesp) CBPF Brazilian Ctr Res Phys Natl Inst Metrol Qual & Technol |
dc.contributor.author.fl_str_mv |
Costa, A. Gemini-Piperni, S. [UNESP] Alves, A. C. Costa, N. A. [UNESP] Checca, N. R. Leite, P. E. Rocha, L. A. [UNESP] Pinto, A. M. P. Toptan, F. [UNESP] Rossi, A. L. Ribeiro, A. R. [UNESP] |
dc.subject.por.fl_str_mv |
Sr Micro-arc oxidation TiO2 Orthopedics implants |
topic |
Sr Micro-arc oxidation TiO2 Orthopedics implants |
description |
One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T12:37:26Z 2021-06-25T12:37:26Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.msec.2020.111735 Materials Science & Engineering C-materials For Biological Applications. Amsterdam: Elsevier, v. 120, 11 p., 2021. 0928-4931 http://hdl.handle.net/11449/210033 10.1016/j.msec.2020.111735 WOS:000617983800004 |
url |
http://dx.doi.org/10.1016/j.msec.2020.111735 http://hdl.handle.net/11449/210033 |
identifier_str_mv |
Materials Science & Engineering C-materials For Biological Applications. Amsterdam: Elsevier, v. 120, 11 p., 2021. 0928-4931 10.1016/j.msec.2020.111735 WOS:000617983800004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Science & Engineering C-materials For Biological Applications |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789489825841152 |