Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.etap.2015.12.020 http://hdl.handle.net/11449/172485 |
Resumo: | Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158 ± 13 mmHg), no significant changes were observed in Control group (127 ± 3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46 ± 0.09 μg/mL versus 0.17 ± 0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil. |
id |
UNSP_99bfe032003b88d2f0272f84ec7ae126 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/172485 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of ratsBiomarkersCardiovascular toxicityFipronilPesticidesRecent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158 ± 13 mmHg), no significant changes were observed in Control group (127 ± 3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46 ± 0.09 μg/mL versus 0.17 ± 0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil.Center for Toxicological Assistance Biosciences Institute of Botucatu Sao Paulo State University - UNESPDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University - UNESPCenter for Toxicological Assistance Biosciences Institute of Botucatu Sao Paulo State University - UNESPDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University - UNESPUniversidade Estadual Paulista (Unesp)Chaguri, Joao Leandro [UNESP]Godinho, Antonio Francisco [UNESP]Horta, Daniel França [UNESP]Gonçalves-Rizzi, Victor Hugo [UNESP]Possomato-Vieira, Jose Sergio [UNESP]Nascimento, Regina Aparecida [UNESP]Dias-Junior, Carlos Alan [UNESP]2018-12-11T17:00:36Z2018-12-11T17:00:36Z2016-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article63-68application/pdfhttp://dx.doi.org/10.1016/j.etap.2015.12.020Environmental Toxicology and Pharmacology, v. 42, p. 63-68.1872-70771382-6689http://hdl.handle.net/11449/17248510.1016/j.etap.2015.12.0202-s2.0-849566764162-s2.0-84956676416.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Toxicology and Pharmacology0,813info:eu-repo/semantics/openAccess2024-04-10T18:10:59Zoai:repositorio.unesp.br:11449/172485Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-10T18:10:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
title |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
spellingShingle |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats Chaguri, Joao Leandro [UNESP] Biomarkers Cardiovascular toxicity Fipronil Pesticides |
title_short |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
title_full |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
title_fullStr |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
title_full_unstemmed |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
title_sort |
Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats |
author |
Chaguri, Joao Leandro [UNESP] |
author_facet |
Chaguri, Joao Leandro [UNESP] Godinho, Antonio Francisco [UNESP] Horta, Daniel França [UNESP] Gonçalves-Rizzi, Victor Hugo [UNESP] Possomato-Vieira, Jose Sergio [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos Alan [UNESP] |
author_role |
author |
author2 |
Godinho, Antonio Francisco [UNESP] Horta, Daniel França [UNESP] Gonçalves-Rizzi, Victor Hugo [UNESP] Possomato-Vieira, Jose Sergio [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos Alan [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Chaguri, Joao Leandro [UNESP] Godinho, Antonio Francisco [UNESP] Horta, Daniel França [UNESP] Gonçalves-Rizzi, Victor Hugo [UNESP] Possomato-Vieira, Jose Sergio [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos Alan [UNESP] |
dc.subject.por.fl_str_mv |
Biomarkers Cardiovascular toxicity Fipronil Pesticides |
topic |
Biomarkers Cardiovascular toxicity Fipronil Pesticides |
description |
Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158 ± 13 mmHg), no significant changes were observed in Control group (127 ± 3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46 ± 0.09 μg/mL versus 0.17 ± 0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 2018-12-11T17:00:36Z 2018-12-11T17:00:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.etap.2015.12.020 Environmental Toxicology and Pharmacology, v. 42, p. 63-68. 1872-7077 1382-6689 http://hdl.handle.net/11449/172485 10.1016/j.etap.2015.12.020 2-s2.0-84956676416 2-s2.0-84956676416.pdf |
url |
http://dx.doi.org/10.1016/j.etap.2015.12.020 http://hdl.handle.net/11449/172485 |
identifier_str_mv |
Environmental Toxicology and Pharmacology, v. 42, p. 63-68. 1872-7077 1382-6689 10.1016/j.etap.2015.12.020 2-s2.0-84956676416 2-s2.0-84956676416.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Toxicology and Pharmacology 0,813 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
63-68 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789950526095360 |