Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765202120190366 http://hdl.handle.net/11449/207669 |
Resumo: | Candida spp. are naturally opportunistic and can promote infections. These yeasts can form biofilm, after penetration and adhesion to the biotic or abiotic surfaces. Preexisting diseases, treatments with drugs and radiation therapy, medical procedures, and parafunctional habits favor the installation of a fungal infection. Increased resistance to the available antifungals has become a concern. Therefore, alternative methods to control them have been evaluated, including the use of plant substances. In this study, the antibiofilm effect of R. officinalis L. extract was analyzed on C. albicans, C. dubliniensis, C. glabrata, C. krusei, and C. tropicalis. A phytochemical analysis of the extract was performed. Biofilms were formed for 48 h and exposed to the different concentrations of the extract (50, 100, and 200 mg/mL) for 5 min or 24 h. The effect of the plant extract was compared to the antifungal nystatin. Rosmarinus officinalis L. extract was constituted of phenols and flavonoids, highlighting the presence of chlorogenic acid derivatives in its composition. Biofilm reductions were observed after exposure to the plant extract for both periods. The plant extract provided a reduction similar to the antifungal. Thus, R. officinalis L. extract showed antibiofilm effect on Candida spp. comparable to the nystatin. |
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Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samplesAntifungal effectBiofilmsCandida sppNystatin; Rosmarinus officinalis LCandida spp. are naturally opportunistic and can promote infections. These yeasts can form biofilm, after penetration and adhesion to the biotic or abiotic surfaces. Preexisting diseases, treatments with drugs and radiation therapy, medical procedures, and parafunctional habits favor the installation of a fungal infection. Increased resistance to the available antifungals has become a concern. Therefore, alternative methods to control them have been evaluated, including the use of plant substances. In this study, the antibiofilm effect of R. officinalis L. extract was analyzed on C. albicans, C. dubliniensis, C. glabrata, C. krusei, and C. tropicalis. A phytochemical analysis of the extract was performed. Biofilms were formed for 48 h and exposed to the different concentrations of the extract (50, 100, and 200 mg/mL) for 5 min or 24 h. The effect of the plant extract was compared to the antifungal nystatin. Rosmarinus officinalis L. extract was constituted of phenols and flavonoids, highlighting the presence of chlorogenic acid derivatives in its composition. Biofilm reductions were observed after exposure to the plant extract for both periods. The plant extract provided a reduction similar to the antifungal. Thus, R. officinalis L. extract showed antibiofilm effect on Candida spp. comparable to the nystatin.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista(UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Bucal, Av. Engenheiro Francisco José Longo, 777Universidade Anhembi Morumbi Escola de Medicina, Av. Dep. Benedito Matarazzo, 4050Universidade Anhanguera Departamento de Farmácia, Av. Raimundo Pereira de Magalhães, 3305Universidade Federal de São Paulo(UNIFESP) Instituto de Farmacologia e Biologia Molecular Departamento de Modo de Ação de Drogas, Rua Três de Maio, 100University of Florida College of Dentistry Department of Restorative Dental SciencesUniversidade Estadual Paulista(UNESP) Instituto de Ciência e Tecnologia Departamento de Odontologia Restauradora, Av. Engenheiro Francisco José Longo, 777,Universidade Estadual Paulista(UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Bucal, Av. Engenheiro Francisco José Longo, 777Universidade Estadual Paulista(UNESP) Instituto de Ciência e Tecnologia Departamento de Odontologia Restauradora, Av. Engenheiro Francisco José Longo, 777,FAPESP: 15/08776-3FAPESP: 15/25338-0Universidade Estadual Paulista (Unesp)Escola de MedicinaUniversidade AnhangueraUniversidade Federal de São Paulo (UNIFESP)College of DentistryMeccatti, Vanessa M. [UNESP]De Oliveira, Jonatas RafaelFigueira, Leandro W. [UNESP]Lagareiro Netto, Amandio A.Zamarioli, Lucas S.Marcucci, Maria C. [UNESP]Camargo, Samira E. A.Carvalho, Cláudio A. T. [UNESP]De Oliveira, Luciane D. [UNESP]2021-06-25T10:59:03Z2021-06-25T10:59:03Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/0001-3765202120190366Anais da Academia Brasileira de Ciencias, v. 93, n. 2, 2021.1678-26900001-3765http://hdl.handle.net/11449/20766910.1590/0001-3765202120190366S0001-376520210003009042-s2.0-85105013040S0001-37652021000300904.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2023-11-29T06:14:52Zoai:repositorio.unesp.br:11449/207669Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-29T06:14:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
title |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
spellingShingle |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples Meccatti, Vanessa M. [UNESP] Antifungal effect Biofilms Candida spp Nystatin; Rosmarinus officinalis L |
title_short |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
title_full |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
title_fullStr |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
title_full_unstemmed |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
title_sort |
Rosmarinus officinalis l. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on candida samples |
author |
Meccatti, Vanessa M. [UNESP] |
author_facet |
Meccatti, Vanessa M. [UNESP] De Oliveira, Jonatas Rafael Figueira, Leandro W. [UNESP] Lagareiro Netto, Amandio A. Zamarioli, Lucas S. Marcucci, Maria C. [UNESP] Camargo, Samira E. A. Carvalho, Cláudio A. T. [UNESP] De Oliveira, Luciane D. [UNESP] |
author_role |
author |
author2 |
De Oliveira, Jonatas Rafael Figueira, Leandro W. [UNESP] Lagareiro Netto, Amandio A. Zamarioli, Lucas S. Marcucci, Maria C. [UNESP] Camargo, Samira E. A. Carvalho, Cláudio A. T. [UNESP] De Oliveira, Luciane D. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Escola de Medicina Universidade Anhanguera Universidade Federal de São Paulo (UNIFESP) College of Dentistry |
dc.contributor.author.fl_str_mv |
Meccatti, Vanessa M. [UNESP] De Oliveira, Jonatas Rafael Figueira, Leandro W. [UNESP] Lagareiro Netto, Amandio A. Zamarioli, Lucas S. Marcucci, Maria C. [UNESP] Camargo, Samira E. A. Carvalho, Cláudio A. T. [UNESP] De Oliveira, Luciane D. [UNESP] |
dc.subject.por.fl_str_mv |
Antifungal effect Biofilms Candida spp Nystatin; Rosmarinus officinalis L |
topic |
Antifungal effect Biofilms Candida spp Nystatin; Rosmarinus officinalis L |
description |
Candida spp. are naturally opportunistic and can promote infections. These yeasts can form biofilm, after penetration and adhesion to the biotic or abiotic surfaces. Preexisting diseases, treatments with drugs and radiation therapy, medical procedures, and parafunctional habits favor the installation of a fungal infection. Increased resistance to the available antifungals has become a concern. Therefore, alternative methods to control them have been evaluated, including the use of plant substances. In this study, the antibiofilm effect of R. officinalis L. extract was analyzed on C. albicans, C. dubliniensis, C. glabrata, C. krusei, and C. tropicalis. A phytochemical analysis of the extract was performed. Biofilms were formed for 48 h and exposed to the different concentrations of the extract (50, 100, and 200 mg/mL) for 5 min or 24 h. The effect of the plant extract was compared to the antifungal nystatin. Rosmarinus officinalis L. extract was constituted of phenols and flavonoids, highlighting the presence of chlorogenic acid derivatives in its composition. Biofilm reductions were observed after exposure to the plant extract for both periods. The plant extract provided a reduction similar to the antifungal. Thus, R. officinalis L. extract showed antibiofilm effect on Candida spp. comparable to the nystatin. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:59:03Z 2021-06-25T10:59:03Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765202120190366 Anais da Academia Brasileira de Ciencias, v. 93, n. 2, 2021. 1678-2690 0001-3765 http://hdl.handle.net/11449/207669 10.1590/0001-3765202120190366 S0001-37652021000300904 2-s2.0-85105013040 S0001-37652021000300904.pdf |
url |
http://dx.doi.org/10.1590/0001-3765202120190366 http://hdl.handle.net/11449/207669 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 93, n. 2, 2021. 1678-2690 0001-3765 10.1590/0001-3765202120190366 S0001-37652021000300904 2-s2.0-85105013040 S0001-37652021000300904.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965111181377536 |