Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1755-7682-3-2 http://hdl.handle.net/11449/71606 |
Resumo: | Background. The literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR. Methods. Male Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (HR/MAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 g/kg) and with a pressor dose of phenylephrine (PHE, 8 g/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05. Results. Baseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001). Conclusion. Eight weeks old SHR already presents impairment of the parasympathetic component of baroreflex. © 2010 Cisternas et al; licensee BioMed Central Ltd. |
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Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive ratsnitroprusside sodiumphenylephrineagedanimal experimentbradycardiacannulationcardiac baroreflexclinical evaluationcontrolled studyfemoral veinheart ratemalemean arterial pressurenonhumanpressoreceptor reflexratspontaneously hypertensive ratWistar Kyoto ratBackground. The literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR. Methods. Male Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (HR/MAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 g/kg) and with a pressor dose of phenylephrine (PHE, 8 g/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05. Results. Baseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001). Conclusion. Eight weeks old SHR already presents impairment of the parasympathetic component of baroreflex. © 2010 Cisternas et al; licensee BioMed Central Ltd.Department of Morphology and Physiology School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650Department of Clinical Medicine Cardiology Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650Department of Medicine Cardiology Division Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032Department of Physiology Federal University of São Paulo (UNIFESP), Rua Napoleo de Barros, 715, Térreo, São Paulo 04039-032Cardiovascular Surgery Division School of Medicine of ABC, Av. Príncipe de Gales, 821, Santo André 09060-650Speech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900Speech Pathology and Audiology Department Faculty of Philosophy and Sciences Paulista State University (UNESP), Av. Hygino Muzzi Filho, 737, Marília 17525-900School of Medicine of ABCUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Cisternas, José RValenti, Vitor Engrácia [UNESP]Alves, Thales BFerreira, CelsoPetenusso, MárcioBreda, João RPires, Adilson CTassi, Nadir [UNESP]Abreu, Luiz Carlos de [UNESP]2014-05-27T11:24:39Z2014-05-27T11:24:39Z2010-03-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1755-7682-3-2International Archives of Medicine, v. 3, n. 1, 2010.1755-7682http://hdl.handle.net/11449/7160610.1186/1755-7682-3-22-s2.0-776493207722-s2.0-77649320772.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Archives of Medicine0,237info:eu-repo/semantics/openAccess2023-11-21T06:09:38Zoai:repositorio.unesp.br:11449/71606Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-21T06:09:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
title |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
spellingShingle |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats Cisternas, José R nitroprusside sodium phenylephrine aged animal experiment bradycardia cannulation cardiac baroreflex clinical evaluation controlled study femoral vein heart rate male mean arterial pressure nonhuman pressoreceptor reflex rat spontaneously hypertensive rat Wistar Kyoto rat |
title_short |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
title_full |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
title_fullStr |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
title_full_unstemmed |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
title_sort |
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats |
author |
Cisternas, José R |
author_facet |
Cisternas, José R Valenti, Vitor Engrácia [UNESP] Alves, Thales B Ferreira, Celso Petenusso, Márcio Breda, João R Pires, Adilson C Tassi, Nadir [UNESP] Abreu, Luiz Carlos de [UNESP] |
author_role |
author |
author2 |
Valenti, Vitor Engrácia [UNESP] Alves, Thales B Ferreira, Celso Petenusso, Márcio Breda, João R Pires, Adilson C Tassi, Nadir [UNESP] Abreu, Luiz Carlos de [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
School of Medicine of ABC Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Cisternas, José R Valenti, Vitor Engrácia [UNESP] Alves, Thales B Ferreira, Celso Petenusso, Márcio Breda, João R Pires, Adilson C Tassi, Nadir [UNESP] Abreu, Luiz Carlos de [UNESP] |
dc.subject.por.fl_str_mv |
nitroprusside sodium phenylephrine aged animal experiment bradycardia cannulation cardiac baroreflex clinical evaluation controlled study femoral vein heart rate male mean arterial pressure nonhuman pressoreceptor reflex rat spontaneously hypertensive rat Wistar Kyoto rat |
topic |
nitroprusside sodium phenylephrine aged animal experiment bradycardia cannulation cardiac baroreflex clinical evaluation controlled study femoral vein heart rate male mean arterial pressure nonhuman pressoreceptor reflex rat spontaneously hypertensive rat Wistar Kyoto rat |
description |
Background. The literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR. Methods. Male Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (HR/MAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 g/kg) and with a pressor dose of phenylephrine (PHE, 8 g/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05. Results. Baseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001). Conclusion. Eight weeks old SHR already presents impairment of the parasympathetic component of baroreflex. © 2010 Cisternas et al; licensee BioMed Central Ltd. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-11 2014-05-27T11:24:39Z 2014-05-27T11:24:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1755-7682-3-2 International Archives of Medicine, v. 3, n. 1, 2010. 1755-7682 http://hdl.handle.net/11449/71606 10.1186/1755-7682-3-2 2-s2.0-77649320772 2-s2.0-77649320772.pdf |
url |
http://dx.doi.org/10.1186/1755-7682-3-2 http://hdl.handle.net/11449/71606 |
identifier_str_mv |
International Archives of Medicine, v. 3, n. 1, 2010. 1755-7682 10.1186/1755-7682-3-2 2-s2.0-77649320772 2-s2.0-77649320772.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Archives of Medicine 0,237 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789772128714752 |