Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224366 |
Resumo: | BACKGROUND AND OBJECTIVES: Infrarenal aortic cross-clamping is associated to cardiovascular effects. Clonidine, an α2-agonist, determines bradycardia and hypotension. This study aimed at analyzing the effects of clonidine on the cardiovascular function of dogs submitted to infrarenal aortic cross-clamping. METHODS: This randomized study involved 16 mixed breed dogs randomly distributed in two groups: G Control - no clonidine; and G Clon - clonidine (5 μg.kg-1 immediately before aortic cross-clamping, followed by 2 μg.min-1.m2 until the end of the study. All dogs were submitted to infrarenal aortic cross-clamping during 45 minutes. Hemodynamic parameters were measured at control (C), 10 (Ao10) and 25 (Ao25) minutes after aortic cross-clamping, and 10 (DAo10) and 25 (DAo25) minutes after aortic unclamping. RESULTS: There were significant differences between groups in heart rate, mean blood pressure and cardiac index (G control > G Clon) during aortic cross-clamping. Afteraortic unclamping there were significant differences between groups in heart rate (G Control > G Clon), and right atrium and pulmonary capillary wedge pressures (G Clon > G Control). During aortic cross-clamping both groups have shown significant increase in right atrium pressure, pulmonary capillary wedge pressure, stroke volume index and left ventricular systolic work index, and significant decrease in pulmonary vascular resistance index. There has been significant increase in mean blood pressure, pulmonary artery pressure, cardiac index and right ventricular systolic work index in the G Control. The clonidine group has shown significant heart rate decrease. After aortic unclamping, both groups have shown significant heart rate and mean blood pressure decrease, while right atrium pressure and stroke volume index remained high. Right ventricular systolic work index remained high in the control group, while cardiac index values returned to close to baseline values. In the clonidine group, right atrium pressure, pulmonary wedge pressure and systolic index remained significantly high. CONCLUSIONS: In dogs under our experimental conditions, continuous intravenous clonidine has attenuated cardiovascular responses to infrarenal aortic cross-clamping. |
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Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cãoEffects of clonidine on cardiovascular responses to infrarenal aortic cross-clamping. Experimental study in dogsAnimal: dogDrugs, α2-agonist: clonidineHemodynamics: cardiovascularSurgery, Vascular: infrarenal aortic cross-clampingBACKGROUND AND OBJECTIVES: Infrarenal aortic cross-clamping is associated to cardiovascular effects. Clonidine, an α2-agonist, determines bradycardia and hypotension. This study aimed at analyzing the effects of clonidine on the cardiovascular function of dogs submitted to infrarenal aortic cross-clamping. METHODS: This randomized study involved 16 mixed breed dogs randomly distributed in two groups: G Control - no clonidine; and G Clon - clonidine (5 μg.kg-1 immediately before aortic cross-clamping, followed by 2 μg.min-1.m2 until the end of the study. All dogs were submitted to infrarenal aortic cross-clamping during 45 minutes. Hemodynamic parameters were measured at control (C), 10 (Ao10) and 25 (Ao25) minutes after aortic cross-clamping, and 10 (DAo10) and 25 (DAo25) minutes after aortic unclamping. RESULTS: There were significant differences between groups in heart rate, mean blood pressure and cardiac index (G control > G Clon) during aortic cross-clamping. Afteraortic unclamping there were significant differences between groups in heart rate (G Control > G Clon), and right atrium and pulmonary capillary wedge pressures (G Clon > G Control). During aortic cross-clamping both groups have shown significant increase in right atrium pressure, pulmonary capillary wedge pressure, stroke volume index and left ventricular systolic work index, and significant decrease in pulmonary vascular resistance index. There has been significant increase in mean blood pressure, pulmonary artery pressure, cardiac index and right ventricular systolic work index in the G Control. The clonidine group has shown significant heart rate decrease. After aortic unclamping, both groups have shown significant heart rate and mean blood pressure decrease, while right atrium pressure and stroke volume index remained high. Right ventricular systolic work index remained high in the control group, while cardiac index values returned to close to baseline values. In the clonidine group, right atrium pressure, pulmonary wedge pressure and systolic index remained significantly high. CONCLUSIONS: In dogs under our experimental conditions, continuous intravenous clonidine has attenuated cardiovascular responses to infrarenal aortic cross-clamping.Dept. de Anestesiologia da FMB UNESP, 18618-970 Botucatu, SPDept. de Anestesiologia da FMB UNESP, 18618-970 Botucatu, SPUniversidade Estadual Paulista (UNESP)Achôa, Renato ViccárioVane, Luiz Antonio [UNESP]Braz, José Reinaldo Cerqueira [UNESP]2022-04-28T19:56:07Z2022-04-28T19:56:07Z2003-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article610-622Revista Brasileira de Anestesiologia, v. 53, n. 5, p. 610-622, 2003.0034-7094http://hdl.handle.net/11449/2243662-s2.0-0141815824Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporengRevista Brasileira de Anestesiologiainfo:eu-repo/semantics/openAccess2022-04-28T19:56:07Zoai:repositorio.unesp.br:11449/224366Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:56:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão Effects of clonidine on cardiovascular responses to infrarenal aortic cross-clamping. Experimental study in dogs |
title |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
spellingShingle |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão Achôa, Renato Viccário Animal: dog Drugs, α2-agonist: clonidine Hemodynamics: cardiovascular Surgery, Vascular: infrarenal aortic cross-clamping |
title_short |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
title_full |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
title_fullStr |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
title_full_unstemmed |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
title_sort |
Efeitos da clonidina nas respostas cardiovasculares ao pinçamento aórtico infra-renal. Estudo experimental no cão |
author |
Achôa, Renato Viccário |
author_facet |
Achôa, Renato Viccário Vane, Luiz Antonio [UNESP] Braz, José Reinaldo Cerqueira [UNESP] |
author_role |
author |
author2 |
Vane, Luiz Antonio [UNESP] Braz, José Reinaldo Cerqueira [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Achôa, Renato Viccário Vane, Luiz Antonio [UNESP] Braz, José Reinaldo Cerqueira [UNESP] |
dc.subject.por.fl_str_mv |
Animal: dog Drugs, α2-agonist: clonidine Hemodynamics: cardiovascular Surgery, Vascular: infrarenal aortic cross-clamping |
topic |
Animal: dog Drugs, α2-agonist: clonidine Hemodynamics: cardiovascular Surgery, Vascular: infrarenal aortic cross-clamping |
description |
BACKGROUND AND OBJECTIVES: Infrarenal aortic cross-clamping is associated to cardiovascular effects. Clonidine, an α2-agonist, determines bradycardia and hypotension. This study aimed at analyzing the effects of clonidine on the cardiovascular function of dogs submitted to infrarenal aortic cross-clamping. METHODS: This randomized study involved 16 mixed breed dogs randomly distributed in two groups: G Control - no clonidine; and G Clon - clonidine (5 μg.kg-1 immediately before aortic cross-clamping, followed by 2 μg.min-1.m2 until the end of the study. All dogs were submitted to infrarenal aortic cross-clamping during 45 minutes. Hemodynamic parameters were measured at control (C), 10 (Ao10) and 25 (Ao25) minutes after aortic cross-clamping, and 10 (DAo10) and 25 (DAo25) minutes after aortic unclamping. RESULTS: There were significant differences between groups in heart rate, mean blood pressure and cardiac index (G control > G Clon) during aortic cross-clamping. Afteraortic unclamping there were significant differences between groups in heart rate (G Control > G Clon), and right atrium and pulmonary capillary wedge pressures (G Clon > G Control). During aortic cross-clamping both groups have shown significant increase in right atrium pressure, pulmonary capillary wedge pressure, stroke volume index and left ventricular systolic work index, and significant decrease in pulmonary vascular resistance index. There has been significant increase in mean blood pressure, pulmonary artery pressure, cardiac index and right ventricular systolic work index in the G Control. The clonidine group has shown significant heart rate decrease. After aortic unclamping, both groups have shown significant heart rate and mean blood pressure decrease, while right atrium pressure and stroke volume index remained high. Right ventricular systolic work index remained high in the control group, while cardiac index values returned to close to baseline values. In the clonidine group, right atrium pressure, pulmonary wedge pressure and systolic index remained significantly high. CONCLUSIONS: In dogs under our experimental conditions, continuous intravenous clonidine has attenuated cardiovascular responses to infrarenal aortic cross-clamping. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-09-01 2022-04-28T19:56:07Z 2022-04-28T19:56:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Revista Brasileira de Anestesiologia, v. 53, n. 5, p. 610-622, 2003. 0034-7094 http://hdl.handle.net/11449/224366 2-s2.0-0141815824 |
identifier_str_mv |
Revista Brasileira de Anestesiologia, v. 53, n. 5, p. 610-622, 2003. 0034-7094 2-s2.0-0141815824 |
url |
http://hdl.handle.net/11449/224366 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Anestesiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
610-622 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789728798408704 |