Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2012.03.004 http://hdl.handle.net/11449/75767 |
Resumo: | Two Quarter Horse mares with hereditary equine regional dermal asthenia (HERDA) were diagnosed with metastatic squamous cell carcinoma (SCC) associated with chronic nonhealing wounds. The lesions were similar to the development of SCC from chronic nonhealing ulcers, known as Marjolin's ulcers in humans. The horses showed recurrent skin wounds in the saddle and paralumbar regions and were confirmed by molecular techniques as having HERDA. Both horses were maintained as research animals for prolonged periods and received regular veterinary care and wound treatment. Both horses were ultimately euthanized because of their chronic progressive wounds, coupled with declining health. At necropsy, the nonhealing wounds were found to be complicated by infiltrative SCC; both horses had metastasis to lungs. Chronically inflamed, recurrent skin wounds that heal slowly and incompletely as a consequence of HERDA are proposed as a major pathogenetic factor in tumorigenesis. Consistent findings with respect to proliferation index (Ki-67) and mutations of p53 tumor suppressor gene were confirmed by immunohistochemistry in one horse. SCC consistent with Marjolin's ulcer has been previously suggested in association with chronic ulcers or burn scars in horses, but this is the first report of an association with chronic poor healing wounds in HERDA horses. © 2013 Elsevier Inc. |
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Marjolin's ulcer in two horses with hereditary equine regional dermal astheniaHERDAHorseMarjolin's ulcerSquamous cell carcinomaAnimaliaEquidaeTwo Quarter Horse mares with hereditary equine regional dermal asthenia (HERDA) were diagnosed with metastatic squamous cell carcinoma (SCC) associated with chronic nonhealing wounds. The lesions were similar to the development of SCC from chronic nonhealing ulcers, known as Marjolin's ulcers in humans. The horses showed recurrent skin wounds in the saddle and paralumbar regions and were confirmed by molecular techniques as having HERDA. Both horses were maintained as research animals for prolonged periods and received regular veterinary care and wound treatment. Both horses were ultimately euthanized because of their chronic progressive wounds, coupled with declining health. At necropsy, the nonhealing wounds were found to be complicated by infiltrative SCC; both horses had metastasis to lungs. Chronically inflamed, recurrent skin wounds that heal slowly and incompletely as a consequence of HERDA are proposed as a major pathogenetic factor in tumorigenesis. Consistent findings with respect to proliferation index (Ki-67) and mutations of p53 tumor suppressor gene were confirmed by immunohistochemistry in one horse. SCC consistent with Marjolin's ulcer has been previously suggested in association with chronic ulcers or burn scars in horses, but this is the first report of an association with chronic poor healing wounds in HERDA horses. © 2013 Elsevier Inc.Department of Veterinary Clinical Science School of Veterinary Medicine and Animal Science Universidade Estadual Paulista (UNESP), Botucatu, São PauloDepartment of Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University, East Lansing, MIDepartment of Pathobiology and Population Medicine Mississippi State University, Mississippi State, MSDepartment of Veterinary Medicine School of Veterinary Medicine Universidade Federal de Goiás (UFG), Goiânia, GoiásDepartment of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University, East Lansing, MIDepartment of Veterinary Medicine Universidade Federal de Viçosa (UFV), Viçosa, Minas GeraisDepartment of Clinical Sciences Mississippi State University, Mississippi, MSDepartment of Veterinary Clinical Science School of Veterinary Medicine and Animal Science Universidade Estadual Paulista (UNESP), Botucatu, São PauloUniversidade Estadual Paulista (Unesp)Michigan State UniversityMississippi State UniversityUniversidade Federal de Goiás (UFG)Universidade Federal de Viçosa (UFV)Badial, Peres R. [UNESP]Rashmir-Raven, Ann M.Cagnini, Didier Q. [UNESP]Oliveira-Filho, José P. [UNESP]Cooley, Avery J.Cunha, Paulo Henrique J.Kitchell, Barbara E.Conceição, Lissandro G.Mochal, Cathleen A.Borges, Alexandre Secorun [UNESP]2014-05-27T11:29:49Z2014-05-27T11:29:49Z2013-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article515-522application/pdfhttp://dx.doi.org/10.1016/j.jevs.2012.03.004Journal of Equine Veterinary Science, v. 33, n. 7, p. 515-522, 2013.0737-0806http://hdl.handle.net/11449/7576710.1016/j.jevs.2012.03.004WOS:0003217940000062-s2.0-848797797082-s2.0-84879779708.pdf9643433706163946Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Science0.8800,390info:eu-repo/semantics/openAccess2023-10-29T06:09:32Zoai:repositorio.unesp.br:11449/75767Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-29T06:09:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
title |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
spellingShingle |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia Badial, Peres R. [UNESP] HERDA Horse Marjolin's ulcer Squamous cell carcinoma Animalia Equidae |
title_short |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
title_full |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
title_fullStr |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
title_full_unstemmed |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
title_sort |
Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia |
author |
Badial, Peres R. [UNESP] |
author_facet |
Badial, Peres R. [UNESP] Rashmir-Raven, Ann M. Cagnini, Didier Q. [UNESP] Oliveira-Filho, José P. [UNESP] Cooley, Avery J. Cunha, Paulo Henrique J. Kitchell, Barbara E. Conceição, Lissandro G. Mochal, Cathleen A. Borges, Alexandre Secorun [UNESP] |
author_role |
author |
author2 |
Rashmir-Raven, Ann M. Cagnini, Didier Q. [UNESP] Oliveira-Filho, José P. [UNESP] Cooley, Avery J. Cunha, Paulo Henrique J. Kitchell, Barbara E. Conceição, Lissandro G. Mochal, Cathleen A. Borges, Alexandre Secorun [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Michigan State University Mississippi State University Universidade Federal de Goiás (UFG) Universidade Federal de Viçosa (UFV) |
dc.contributor.author.fl_str_mv |
Badial, Peres R. [UNESP] Rashmir-Raven, Ann M. Cagnini, Didier Q. [UNESP] Oliveira-Filho, José P. [UNESP] Cooley, Avery J. Cunha, Paulo Henrique J. Kitchell, Barbara E. Conceição, Lissandro G. Mochal, Cathleen A. Borges, Alexandre Secorun [UNESP] |
dc.subject.por.fl_str_mv |
HERDA Horse Marjolin's ulcer Squamous cell carcinoma Animalia Equidae |
topic |
HERDA Horse Marjolin's ulcer Squamous cell carcinoma Animalia Equidae |
description |
Two Quarter Horse mares with hereditary equine regional dermal asthenia (HERDA) were diagnosed with metastatic squamous cell carcinoma (SCC) associated with chronic nonhealing wounds. The lesions were similar to the development of SCC from chronic nonhealing ulcers, known as Marjolin's ulcers in humans. The horses showed recurrent skin wounds in the saddle and paralumbar regions and were confirmed by molecular techniques as having HERDA. Both horses were maintained as research animals for prolonged periods and received regular veterinary care and wound treatment. Both horses were ultimately euthanized because of their chronic progressive wounds, coupled with declining health. At necropsy, the nonhealing wounds were found to be complicated by infiltrative SCC; both horses had metastasis to lungs. Chronically inflamed, recurrent skin wounds that heal slowly and incompletely as a consequence of HERDA are proposed as a major pathogenetic factor in tumorigenesis. Consistent findings with respect to proliferation index (Ki-67) and mutations of p53 tumor suppressor gene were confirmed by immunohistochemistry in one horse. SCC consistent with Marjolin's ulcer has been previously suggested in association with chronic ulcers or burn scars in horses, but this is the first report of an association with chronic poor healing wounds in HERDA horses. © 2013 Elsevier Inc. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-01 2014-05-27T11:29:49Z 2014-05-27T11:29:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2012.03.004 Journal of Equine Veterinary Science, v. 33, n. 7, p. 515-522, 2013. 0737-0806 http://hdl.handle.net/11449/75767 10.1016/j.jevs.2012.03.004 WOS:000321794000006 2-s2.0-84879779708 2-s2.0-84879779708.pdf 9643433706163946 |
url |
http://dx.doi.org/10.1016/j.jevs.2012.03.004 http://hdl.handle.net/11449/75767 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 33, n. 7, p. 515-522, 2013. 0737-0806 10.1016/j.jevs.2012.03.004 WOS:000321794000006 2-s2.0-84879779708 2-s2.0-84879779708.pdf 9643433706163946 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science 0.880 0,390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
515-522 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964746119643136 |