Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1139/cjpp-2014-0259 http://hdl.handle.net/11449/117191 |
Resumo: | The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age-and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age with either dexamethasone (1.0 mg/kg body mass, intraperitoneally) or saline, daily for 5 days. All of the GC-treated rats had decreased body mass and food intake, and adrenal hypotrophy. Increased glycemia was observed in all of the GC-treated groups and only the 3-month-old female rats were not glucose intolerant. Dexamethasone treatment resulted in hyperinsulinemia and hypertriacylglyceridemia in all of the GC-treated rats. The glucose-stimulated insulin secretion (GSIS) was higher in all of the dexamethasone-treated animals, but it was less pronounced in the older animals. The beta-cell mass was increased in the younger male rats treated with dexamethasone. We conclude that dexamethasone treatment induces glucose intolerance in both the 3- and 12-month-old male rats as well as hyperinsulinemia and augmented GSIS. Three-month-old female rats are protected from glucose intolerance caused by GC, whereas 12-month-old female rats developed the same complications that were present in 3- and 12-month-old male rats. |
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Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated ratsdexamethasonefemaleglucose toleranceinsulin secretioninsulin sensitivityThe disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age-and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age with either dexamethasone (1.0 mg/kg body mass, intraperitoneally) or saline, daily for 5 days. All of the GC-treated rats had decreased body mass and food intake, and adrenal hypotrophy. Increased glycemia was observed in all of the GC-treated groups and only the 3-month-old female rats were not glucose intolerant. Dexamethasone treatment resulted in hyperinsulinemia and hypertriacylglyceridemia in all of the GC-treated rats. The glucose-stimulated insulin secretion (GSIS) was higher in all of the dexamethasone-treated animals, but it was less pronounced in the older animals. The beta-cell mass was increased in the younger male rats treated with dexamethasone. We conclude that dexamethasone treatment induces glucose intolerance in both the 3- and 12-month-old male rats as well as hyperinsulinemia and augmented GSIS. Three-month-old female rats are protected from glucose intolerance caused by GC, whereas 12-month-old female rats developed the same complications that were present in 3- and 12-month-old male rats.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Nacional de Ciencia e Tecnologia: Obesidade e DiabetesFed Univ Santa Catarina UFSC, Dept Physiol Sci, Ctr Biol Sci, BR-88040900 Florianopolis, SC, BrazilSao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, BrazilState Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, BrazilState Univ Campinas UNICAMP, OCRC, Campinas, SP, BrazilSao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, BrazilCNPq: 471397/2011-3Canadian Science Publishing, Nrc Research PressUniversidade Federal de Santa Catarina (UFSC)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Santos, Cristiane dosFerreira, Francielle Batista D.Goncalves-Neto, Luiz M.Taboga, Sebastiao Roberto [UNESP]Boschero, Antonio CarlosRafacho, Alex2015-03-18T15:55:24Z2015-03-18T15:55:24Z2014-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article867-878http://dx.doi.org/10.1139/cjpp-2014-0259Canadian Journal Of Physiology And Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 92, n. 10, p. 867-878, 2014.0008-4212http://hdl.handle.net/11449/11719110.1139/cjpp-2014-0259WOS:00034309950000914452594685261880000-0002-0970-4288Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCanadian Journal Of Physiology And Pharmacology2.2100,724info:eu-repo/semantics/openAccess2021-10-23T04:15:50Zoai:repositorio.unesp.br:11449/117191Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T04:15:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
title |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
spellingShingle |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats Santos, Cristiane dos dexamethasone female glucose tolerance insulin secretion insulin sensitivity |
title_short |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
title_full |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
title_fullStr |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
title_full_unstemmed |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
title_sort |
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats |
author |
Santos, Cristiane dos |
author_facet |
Santos, Cristiane dos Ferreira, Francielle Batista D. Goncalves-Neto, Luiz M. Taboga, Sebastiao Roberto [UNESP] Boschero, Antonio Carlos Rafacho, Alex |
author_role |
author |
author2 |
Ferreira, Francielle Batista D. Goncalves-Neto, Luiz M. Taboga, Sebastiao Roberto [UNESP] Boschero, Antonio Carlos Rafacho, Alex |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Santa Catarina (UFSC) Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Santos, Cristiane dos Ferreira, Francielle Batista D. Goncalves-Neto, Luiz M. Taboga, Sebastiao Roberto [UNESP] Boschero, Antonio Carlos Rafacho, Alex |
dc.subject.por.fl_str_mv |
dexamethasone female glucose tolerance insulin secretion insulin sensitivity |
topic |
dexamethasone female glucose tolerance insulin secretion insulin sensitivity |
description |
The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age-and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age with either dexamethasone (1.0 mg/kg body mass, intraperitoneally) or saline, daily for 5 days. All of the GC-treated rats had decreased body mass and food intake, and adrenal hypotrophy. Increased glycemia was observed in all of the GC-treated groups and only the 3-month-old female rats were not glucose intolerant. Dexamethasone treatment resulted in hyperinsulinemia and hypertriacylglyceridemia in all of the GC-treated rats. The glucose-stimulated insulin secretion (GSIS) was higher in all of the dexamethasone-treated animals, but it was less pronounced in the older animals. The beta-cell mass was increased in the younger male rats treated with dexamethasone. We conclude that dexamethasone treatment induces glucose intolerance in both the 3- and 12-month-old male rats as well as hyperinsulinemia and augmented GSIS. Three-month-old female rats are protected from glucose intolerance caused by GC, whereas 12-month-old female rats developed the same complications that were present in 3- and 12-month-old male rats. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-01 2015-03-18T15:55:24Z 2015-03-18T15:55:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1139/cjpp-2014-0259 Canadian Journal Of Physiology And Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 92, n. 10, p. 867-878, 2014. 0008-4212 http://hdl.handle.net/11449/117191 10.1139/cjpp-2014-0259 WOS:000343099500009 1445259468526188 0000-0002-0970-4288 |
url |
http://dx.doi.org/10.1139/cjpp-2014-0259 http://hdl.handle.net/11449/117191 |
identifier_str_mv |
Canadian Journal Of Physiology And Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 92, n. 10, p. 867-878, 2014. 0008-4212 10.1139/cjpp-2014-0259 WOS:000343099500009 1445259468526188 0000-0002-0970-4288 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Canadian Journal Of Physiology And Pharmacology 2.210 0,724 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
867-878 |
dc.publisher.none.fl_str_mv |
Canadian Science Publishing, Nrc Research Press |
publisher.none.fl_str_mv |
Canadian Science Publishing, Nrc Research Press |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964970459332608 |