Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fct.2012.07.009 http://hdl.handle.net/11449/16909 |
Resumo: | We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved. |
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Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterationsMonosodium glutamateLipid profileMetabolismQuercetinHepatoprotectionAntioxidant defensesWe reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP Univ State São Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP, BrazilUNESP Univ State São Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP, BrazilUNICAMP Univ Campinas, Inst Biol, Dept Anat Cellular Biol Physiol & Biophys, Campinas, SP, BrazilUNESP Univ State São Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP, BrazilUNESP Univ State São Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP, BrazilFAPESP: 02/03359-5Pergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Seiva, Fabio R. F. [UNESP]Chuffa, Luiz Gustavo A. [UNESP]Braga, Camila Pereira [UNESP]Amorim, Joao Paulo A.Fernandes, Ana Angelica H. [UNESP]2014-05-20T13:47:30Z2014-05-20T13:47:30Z2012-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3556-3561application/pdfhttp://dx.doi.org/10.1016/j.fct.2012.07.009Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 10, p. 3556-3561, 2012.0278-6915http://hdl.handle.net/11449/1690910.1016/j.fct.2012.07.009WOS:000309897100025WOS000309897100025.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicology3.9771,144info:eu-repo/semantics/openAccess2023-11-02T06:11:26Zoai:repositorio.unesp.br:11449/16909Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-02T06:11:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
title |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
spellingShingle |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations Seiva, Fabio R. F. [UNESP] Monosodium glutamate Lipid profile Metabolism Quercetin Hepatoprotection Antioxidant defenses |
title_short |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
title_full |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
title_fullStr |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
title_full_unstemmed |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
title_sort |
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations |
author |
Seiva, Fabio R. F. [UNESP] |
author_facet |
Seiva, Fabio R. F. [UNESP] Chuffa, Luiz Gustavo A. [UNESP] Braga, Camila Pereira [UNESP] Amorim, Joao Paulo A. Fernandes, Ana Angelica H. [UNESP] |
author_role |
author |
author2 |
Chuffa, Luiz Gustavo A. [UNESP] Braga, Camila Pereira [UNESP] Amorim, Joao Paulo A. Fernandes, Ana Angelica H. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Seiva, Fabio R. F. [UNESP] Chuffa, Luiz Gustavo A. [UNESP] Braga, Camila Pereira [UNESP] Amorim, Joao Paulo A. Fernandes, Ana Angelica H. [UNESP] |
dc.subject.por.fl_str_mv |
Monosodium glutamate Lipid profile Metabolism Quercetin Hepatoprotection Antioxidant defenses |
topic |
Monosodium glutamate Lipid profile Metabolism Quercetin Hepatoprotection Antioxidant defenses |
description |
We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 2014-05-20T13:47:30Z 2014-05-20T13:47:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fct.2012.07.009 Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 10, p. 3556-3561, 2012. 0278-6915 http://hdl.handle.net/11449/16909 10.1016/j.fct.2012.07.009 WOS:000309897100025 WOS000309897100025.pdf |
url |
http://dx.doi.org/10.1016/j.fct.2012.07.009 http://hdl.handle.net/11449/16909 |
identifier_str_mv |
Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 10, p. 3556-3561, 2012. 0278-6915 10.1016/j.fct.2012.07.009 WOS:000309897100025 WOS000309897100025.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food and Chemical Toxicology 3.977 1,144 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3556-3561 application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964794260815872 |