Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen

Detalhes bibliográficos
Autor(a) principal: Gálico, D. A. [UNESP]
Data de Publicação: 2016
Outros Autores: Fraga-Silva, T. F.C. [UNESP], Venturini, J. [UNESP], Bannach, G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tca.2016.10.007
http://hdl.handle.net/11449/173710
Resumo: Solid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.
id UNSP_a28e241fb20c29f9e82b8ae38a590bcc
oai_identifier_str oai:repositorio.unesp.br:11449/173710
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxenIn vitro biological studiesLanthanumNaproxenPolymorphismSpectroscopic studiesThermal behaviorSolid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNICAMP—Univ de Campinas Instituto de química, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Química, CEPUNESP—Univ Estadual Paulista Instituto de biociências, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Ciências Biológicas, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Química, CEPUNESP—Univ Estadual Paulista Instituto de biociências, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Ciências Biológicas, CEPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Gálico, D. A. [UNESP]Fraga-Silva, T. F.C. [UNESP]Venturini, J. [UNESP]Bannach, G. [UNESP]2018-12-11T17:07:23Z2018-12-11T17:07:23Z2016-11-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article43-49application/pdfhttp://dx.doi.org/10.1016/j.tca.2016.10.007Thermochimica Acta, v. 644, p. 43-49.0040-6031http://hdl.handle.net/11449/17371010.1016/j.tca.2016.10.0072-s2.0-849939785752-s2.0-84993978575.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Acta0,605info:eu-repo/semantics/openAccess2024-04-29T18:16:46Zoai:repositorio.unesp.br:11449/173710Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:58:50.028654Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
title Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
spellingShingle Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
Gálico, D. A. [UNESP]
In vitro biological studies
Lanthanum
Naproxen
Polymorphism
Spectroscopic studies
Thermal behavior
title_short Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
title_full Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
title_fullStr Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
title_full_unstemmed Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
title_sort Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
author Gálico, D. A. [UNESP]
author_facet Gálico, D. A. [UNESP]
Fraga-Silva, T. F.C. [UNESP]
Venturini, J. [UNESP]
Bannach, G. [UNESP]
author_role author
author2 Fraga-Silva, T. F.C. [UNESP]
Venturini, J. [UNESP]
Bannach, G. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Gálico, D. A. [UNESP]
Fraga-Silva, T. F.C. [UNESP]
Venturini, J. [UNESP]
Bannach, G. [UNESP]
dc.subject.por.fl_str_mv In vitro biological studies
Lanthanum
Naproxen
Polymorphism
Spectroscopic studies
Thermal behavior
topic In vitro biological studies
Lanthanum
Naproxen
Polymorphism
Spectroscopic studies
Thermal behavior
description Solid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-20
2018-12-11T17:07:23Z
2018-12-11T17:07:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tca.2016.10.007
Thermochimica Acta, v. 644, p. 43-49.
0040-6031
http://hdl.handle.net/11449/173710
10.1016/j.tca.2016.10.007
2-s2.0-84993978575
2-s2.0-84993978575.pdf
url http://dx.doi.org/10.1016/j.tca.2016.10.007
http://hdl.handle.net/11449/173710
identifier_str_mv Thermochimica Acta, v. 644, p. 43-49.
0040-6031
10.1016/j.tca.2016.10.007
2-s2.0-84993978575
2-s2.0-84993978575.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thermochimica Acta
0,605
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 43-49
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128443159674880