Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tca.2016.10.007 http://hdl.handle.net/11449/173710 |
Resumo: | Solid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells. |
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Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxenIn vitro biological studiesLanthanumNaproxenPolymorphismSpectroscopic studiesThermal behaviorSolid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNICAMP—Univ de Campinas Instituto de química, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Química, CEPUNESP—Univ Estadual Paulista Instituto de biociências, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Ciências Biológicas, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Química, CEPUNESP—Univ Estadual Paulista Instituto de biociências, CEPUNESP—Univ Estadual Paulista Faculdade de Ciências Departamento de Ciências Biológicas, CEPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Gálico, D. A. [UNESP]Fraga-Silva, T. F.C. [UNESP]Venturini, J. [UNESP]Bannach, G. [UNESP]2018-12-11T17:07:23Z2018-12-11T17:07:23Z2016-11-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article43-49application/pdfhttp://dx.doi.org/10.1016/j.tca.2016.10.007Thermochimica Acta, v. 644, p. 43-49.0040-6031http://hdl.handle.net/11449/17371010.1016/j.tca.2016.10.0072-s2.0-849939785752-s2.0-84993978575.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Acta0,605info:eu-repo/semantics/openAccess2024-04-29T18:16:46Zoai:repositorio.unesp.br:11449/173710Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:58:50.028654Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
title |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
spellingShingle |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen Gálico, D. A. [UNESP] In vitro biological studies Lanthanum Naproxen Polymorphism Spectroscopic studies Thermal behavior |
title_short |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
title_full |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
title_fullStr |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
title_full_unstemmed |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
title_sort |
Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen |
author |
Gálico, D. A. [UNESP] |
author_facet |
Gálico, D. A. [UNESP] Fraga-Silva, T. F.C. [UNESP] Venturini, J. [UNESP] Bannach, G. [UNESP] |
author_role |
author |
author2 |
Fraga-Silva, T. F.C. [UNESP] Venturini, J. [UNESP] Bannach, G. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gálico, D. A. [UNESP] Fraga-Silva, T. F.C. [UNESP] Venturini, J. [UNESP] Bannach, G. [UNESP] |
dc.subject.por.fl_str_mv |
In vitro biological studies Lanthanum Naproxen Polymorphism Spectroscopic studies Thermal behavior |
topic |
In vitro biological studies Lanthanum Naproxen Polymorphism Spectroscopic studies Thermal behavior |
description |
Solid-state [La(Nap)3(H2O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand. [La(Nap)3(H2O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-α, IL-1β and H2O2, and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-20 2018-12-11T17:07:23Z 2018-12-11T17:07:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tca.2016.10.007 Thermochimica Acta, v. 644, p. 43-49. 0040-6031 http://hdl.handle.net/11449/173710 10.1016/j.tca.2016.10.007 2-s2.0-84993978575 2-s2.0-84993978575.pdf |
url |
http://dx.doi.org/10.1016/j.tca.2016.10.007 http://hdl.handle.net/11449/173710 |
identifier_str_mv |
Thermochimica Acta, v. 644, p. 43-49. 0040-6031 10.1016/j.tca.2016.10.007 2-s2.0-84993978575 2-s2.0-84993978575.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Thermochimica Acta 0,605 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
43-49 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128443159674880 |