Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2015/413751 http://hdl.handle.net/11449/131433 |
Resumo: | Few studies have investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic population. This study evaluated the efficacy of uNGAL as predictor of AKI and death in septic patients admitted to the clinical emergency room (ER). We prospectively studied patients with sepsis admitted to the ER. Urine was analyzed for NGAL within the first 24 hours after admission (classified as NGAL1), between 24 and 48 h (NGAL2), and at moment of AKI diagnosis (NGAL3). Among 168 septic patients admitted to ER, 72% developed AKI. The uNGAL and its relationship with creatinine (Cr) were high in septic patients but statistically higher in those with sepsis and AKI. The uNGAL1 and uNGAL2, as well as uNGAL1/uCr1 and uNGAL2/uCr2, were good predictors for AKI (AUC-ROC 0.73, 0.70, 0.77, and 0.84, resp.). The uNGAL1 and uNGAL1/uCr1 were poor predictors for death (AUC-ROC 0.66 and 0.68, resp.), whereas uNGAL2 and uNGAL2/uCr2 were better predictors (AUC-ROC 0.70 and 0.81, resp.). The uNGAL is highly sensitive but nonspecific predictor of AKI and death in septic patients admitted into ER. |
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Sepsis and AKI in clinical emergency room patients: the role of urinary NGALFew studies have investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic population. This study evaluated the efficacy of uNGAL as predictor of AKI and death in septic patients admitted to the clinical emergency room (ER). We prospectively studied patients with sepsis admitted to the ER. Urine was analyzed for NGAL within the first 24 hours after admission (classified as NGAL1), between 24 and 48 h (NGAL2), and at moment of AKI diagnosis (NGAL3). Among 168 septic patients admitted to ER, 72% developed AKI. The uNGAL and its relationship with creatinine (Cr) were high in septic patients but statistically higher in those with sepsis and AKI. The uNGAL1 and uNGAL2, as well as uNGAL1/uCr1 and uNGAL2/uCr2, were good predictors for AKI (AUC-ROC 0.73, 0.70, 0.77, and 0.84, resp.). The uNGAL1 and uNGAL1/uCr1 were poor predictors for death (AUC-ROC 0.66 and 0.68, resp.), whereas uNGAL2 and uNGAL2/uCr2 were better predictors (AUC-ROC 0.70 and 0.81, resp.). The uNGAL is highly sensitive but nonspecific predictor of AKI and death in septic patients admitted into ER.Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrasilFaculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrasilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Nga, Hong Si [UNESP]Medeiros, Pamela [UNESP]Menezes, Precil [UNESP]Bridi, Ramaiane [UNESP]Balbi, André Luís [UNESP]Ponce, Daniela [UNESP]2015-12-07T15:35:26Z2015-12-07T15:35:26Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-9application/pdfhttp://dx.doi.org/10.1155/2015/413751BioMed Research International, v. 2015, p. 1-9, 2015.2314-6141http://hdl.handle.net/11449/13143310.1155/2015/413751PMC4516828.pdf569780449307166126266256PMC4516828PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International0,935info:eu-repo/semantics/openAccess2023-09-30T06:04:14Zoai:repositorio.unesp.br:11449/131433Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-09-30T06:04:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
title |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
spellingShingle |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL Nga, Hong Si [UNESP] |
title_short |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
title_full |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
title_fullStr |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
title_full_unstemmed |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
title_sort |
Sepsis and AKI in clinical emergency room patients: the role of urinary NGAL |
author |
Nga, Hong Si [UNESP] |
author_facet |
Nga, Hong Si [UNESP] Medeiros, Pamela [UNESP] Menezes, Precil [UNESP] Bridi, Ramaiane [UNESP] Balbi, André Luís [UNESP] Ponce, Daniela [UNESP] |
author_role |
author |
author2 |
Medeiros, Pamela [UNESP] Menezes, Precil [UNESP] Bridi, Ramaiane [UNESP] Balbi, André Luís [UNESP] Ponce, Daniela [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nga, Hong Si [UNESP] Medeiros, Pamela [UNESP] Menezes, Precil [UNESP] Bridi, Ramaiane [UNESP] Balbi, André Luís [UNESP] Ponce, Daniela [UNESP] |
description |
Few studies have investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic population. This study evaluated the efficacy of uNGAL as predictor of AKI and death in septic patients admitted to the clinical emergency room (ER). We prospectively studied patients with sepsis admitted to the ER. Urine was analyzed for NGAL within the first 24 hours after admission (classified as NGAL1), between 24 and 48 h (NGAL2), and at moment of AKI diagnosis (NGAL3). Among 168 septic patients admitted to ER, 72% developed AKI. The uNGAL and its relationship with creatinine (Cr) were high in septic patients but statistically higher in those with sepsis and AKI. The uNGAL1 and uNGAL2, as well as uNGAL1/uCr1 and uNGAL2/uCr2, were good predictors for AKI (AUC-ROC 0.73, 0.70, 0.77, and 0.84, resp.). The uNGAL1 and uNGAL1/uCr1 were poor predictors for death (AUC-ROC 0.66 and 0.68, resp.), whereas uNGAL2 and uNGAL2/uCr2 were better predictors (AUC-ROC 0.70 and 0.81, resp.). The uNGAL is highly sensitive but nonspecific predictor of AKI and death in septic patients admitted into ER. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-07T15:35:26Z 2015-12-07T15:35:26Z 2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2015/413751 BioMed Research International, v. 2015, p. 1-9, 2015. 2314-6141 http://hdl.handle.net/11449/131433 10.1155/2015/413751 PMC4516828.pdf 5697804493071661 26266256 PMC4516828 |
url |
http://dx.doi.org/10.1155/2015/413751 http://hdl.handle.net/11449/131433 |
identifier_str_mv |
BioMed Research International, v. 2015, p. 1-9, 2015. 2314-6141 10.1155/2015/413751 PMC4516828.pdf 5697804493071661 26266256 PMC4516828 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-9 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789244172795904 |