The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-3-030-70601-2_15 http://hdl.handle.net/11449/240892 |
Resumo: | Acute rupture of the calcaneus tendon is relatively common, usually related to sports practice. In recent years, the number of researches in search of more efficient techniques, which induce the healing process, has been growing. The Fibrin Sealant Derived from Snake Venom (FSDSV) or Heterologous Sealant has been standing out in animal and human application for accelerating the repair of lesions, reducing the likelihood of hemorrhage and infectious diseases and having low production cost. Aquatic exercise also presents itself as an efficient strategy for rehabilitation, reducing pain and edemas, improving muscle properties and enhancing the repair process due to the numerous beneficial effects provided by the liquid medium. The aim of this research is to evaluate the use of fibrin sealant derived from snake venom associated with aquatic exercise in tendon repair. We used 84 rats of the Wistar strain, weighing between 170 and 250 g of weight who underwent surgery to induce partial rupture of the calcaneus tendon. The animals were randomly separated into four experimental groups. The technique used was the application of fibrin sealant and aquatic exercises according to the studied group. There was a greater reduction in the edema of the animals’ paws from the seventh day on in all treatments (p < 0.002), when compared to the control group. After 7 and 14 days of treatment, LE showed a greater reduction in the volume of edema (p = 0.03041) compared to the control. After 21 days, the (LS) showed a greater reduction in edema compared to the control group. It was possible to verify a higher collagen to LSE ratio in the evaluated period after 21 days of treatment. Thus, the heterologous fibrin sealant associated or not with aquatic exercise has a beneficial influence on tendon repair, becoming a propitious technique for future clinical applications. |
id |
UNSP_aa69c070a68dc8200098cd4546a3c2d3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/240892 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in RatsAquatic exercisesCalcaneus tendonEdemaFibrin sealantAcute rupture of the calcaneus tendon is relatively common, usually related to sports practice. In recent years, the number of researches in search of more efficient techniques, which induce the healing process, has been growing. The Fibrin Sealant Derived from Snake Venom (FSDSV) or Heterologous Sealant has been standing out in animal and human application for accelerating the repair of lesions, reducing the likelihood of hemorrhage and infectious diseases and having low production cost. Aquatic exercise also presents itself as an efficient strategy for rehabilitation, reducing pain and edemas, improving muscle properties and enhancing the repair process due to the numerous beneficial effects provided by the liquid medium. The aim of this research is to evaluate the use of fibrin sealant derived from snake venom associated with aquatic exercise in tendon repair. We used 84 rats of the Wistar strain, weighing between 170 and 250 g of weight who underwent surgery to induce partial rupture of the calcaneus tendon. The animals were randomly separated into four experimental groups. The technique used was the application of fibrin sealant and aquatic exercises according to the studied group. There was a greater reduction in the edema of the animals’ paws from the seventh day on in all treatments (p < 0.002), when compared to the control group. After 7 and 14 days of treatment, LE showed a greater reduction in the volume of edema (p = 0.03041) compared to the control. After 21 days, the (LS) showed a greater reduction in edema compared to the control group. It was possible to verify a higher collagen to LSE ratio in the evaluated period after 21 days of treatment. Thus, the heterologous fibrin sealant associated or not with aquatic exercise has a beneficial influence on tendon repair, becoming a propitious technique for future clinical applications.Universidade BrasilNúcleo de Pesquisa em Biotecnologia e Biodiversidade UESPICentro de Estudos de Venenos e Animais Peçonhentos CEVAP-UNESPFaculdade de Medicina de Botucatu UNESPBiomedical Engineering Universidade Brasil, Rua Carolina Fonseca 235Centro de Estudos de Venenos e Animais Peçonhentos CEVAP-UNESPFaculdade de Medicina de Botucatu UNESPUniversidade BrasilUESPIUniversidade Estadual Paulista (UNESP)Hidd, S. M.C.M.Dutra, E. F.Tim, C. R.Filho, A. L.M.M.Assis, L.Ferreira, R. S. [UNESP]Barraviera, B. [UNESP]Amaral, M. M.2023-03-01T20:37:19Z2023-03-01T20:37:19Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject91-95http://dx.doi.org/10.1007/978-3-030-70601-2_15IFMBE Proceedings, v. 83, p. 91-95.1433-92771680-0737http://hdl.handle.net/11449/24089210.1007/978-3-030-70601-2_152-s2.0-85128956183Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIFMBE Proceedingsinfo:eu-repo/semantics/openAccess2024-04-15T18:33:36Zoai:repositorio.unesp.br:11449/240892Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-15T18:33:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
title |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
spellingShingle |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats Hidd, S. M.C.M. Aquatic exercises Calcaneus tendon Edema Fibrin sealant |
title_short |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
title_full |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
title_fullStr |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
title_full_unstemmed |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
title_sort |
The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats |
author |
Hidd, S. M.C.M. |
author_facet |
Hidd, S. M.C.M. Dutra, E. F. Tim, C. R. Filho, A. L.M.M. Assis, L. Ferreira, R. S. [UNESP] Barraviera, B. [UNESP] Amaral, M. M. |
author_role |
author |
author2 |
Dutra, E. F. Tim, C. R. Filho, A. L.M.M. Assis, L. Ferreira, R. S. [UNESP] Barraviera, B. [UNESP] Amaral, M. M. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Brasil UESPI Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Hidd, S. M.C.M. Dutra, E. F. Tim, C. R. Filho, A. L.M.M. Assis, L. Ferreira, R. S. [UNESP] Barraviera, B. [UNESP] Amaral, M. M. |
dc.subject.por.fl_str_mv |
Aquatic exercises Calcaneus tendon Edema Fibrin sealant |
topic |
Aquatic exercises Calcaneus tendon Edema Fibrin sealant |
description |
Acute rupture of the calcaneus tendon is relatively common, usually related to sports practice. In recent years, the number of researches in search of more efficient techniques, which induce the healing process, has been growing. The Fibrin Sealant Derived from Snake Venom (FSDSV) or Heterologous Sealant has been standing out in animal and human application for accelerating the repair of lesions, reducing the likelihood of hemorrhage and infectious diseases and having low production cost. Aquatic exercise also presents itself as an efficient strategy for rehabilitation, reducing pain and edemas, improving muscle properties and enhancing the repair process due to the numerous beneficial effects provided by the liquid medium. The aim of this research is to evaluate the use of fibrin sealant derived from snake venom associated with aquatic exercise in tendon repair. We used 84 rats of the Wistar strain, weighing between 170 and 250 g of weight who underwent surgery to induce partial rupture of the calcaneus tendon. The animals were randomly separated into four experimental groups. The technique used was the application of fibrin sealant and aquatic exercises according to the studied group. There was a greater reduction in the edema of the animals’ paws from the seventh day on in all treatments (p < 0.002), when compared to the control group. After 7 and 14 days of treatment, LE showed a greater reduction in the volume of edema (p = 0.03041) compared to the control. After 21 days, the (LS) showed a greater reduction in edema compared to the control group. It was possible to verify a higher collagen to LSE ratio in the evaluated period after 21 days of treatment. Thus, the heterologous fibrin sealant associated or not with aquatic exercise has a beneficial influence on tendon repair, becoming a propitious technique for future clinical applications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:37:19Z 2023-03-01T20:37:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-3-030-70601-2_15 IFMBE Proceedings, v. 83, p. 91-95. 1433-9277 1680-0737 http://hdl.handle.net/11449/240892 10.1007/978-3-030-70601-2_15 2-s2.0-85128956183 |
url |
http://dx.doi.org/10.1007/978-3-030-70601-2_15 http://hdl.handle.net/11449/240892 |
identifier_str_mv |
IFMBE Proceedings, v. 83, p. 91-95. 1433-9277 1680-0737 10.1007/978-3-030-70601-2_15 2-s2.0-85128956183 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
IFMBE Proceedings |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
91-95 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965245249159168 |