Primary Tracheal Squamous Cells Carcinoma in a Dog
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p147-152 http://hdl.handle.net/11449/248005 |
Resumo: | Primary tracheal neoplasms are uncommon and poorly documented in veterinary medicine, being most frequently reported in domestic cats. Squamous cell carcinoma (SCC) is a malignant neoplasm that originates from the stratified squamous epithelium, considered one of the most common skin neoplasms in dogs and cats. This paper aims to report the anatomopathological and immunohistochemical findings of a clinical case of primary SCC in the trachea of a female Schnauzer canine, attended at the Veterinary Hospital Luiz Quintiliano de Oliveira of the Faculty of Veterinary Medicine of Araçatuba (FMVA – UNESP), presenting clinical signs such as choking, coughing and dyspnea for 1 month. The tracheal portion affected by the neoplasm was sent to the Veterinary Pathology department of the FMVA after surgical excision. Fragments of the neoplasm were collected and fixed in 10% formaldehyde for further histopathological and immunohistochemical analysis. Microscopically, the neoplasm was well differentiated, being characterized by the presence of keratin pearls, low degree of pleomorphism and rare mitotic figures. In the immunohistochemical analysis, there was immunoexpression of anti-cytokeratin antibodies AE1AE3, 34BE12, CK14 and CK5/6, confirming the diagnosis of squamous cell carcinoma. In about 30% of the cells there was immunostaining for Ki67 antibodies, justifying the low mitotic index of tumor cells and the few images of mitosis seen. Due to the rare occurrence of primary tracheal SCC in dogs, the use of diversified diagnostic techniques is important in order to better understand the biological behavior of this neoplasm in unusual anatomical locations. |
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Primary Tracheal Squamous Cells Carcinoma in a DogcaninehistopathologyneoplasmPrimary tracheal neoplasms are uncommon and poorly documented in veterinary medicine, being most frequently reported in domestic cats. Squamous cell carcinoma (SCC) is a malignant neoplasm that originates from the stratified squamous epithelium, considered one of the most common skin neoplasms in dogs and cats. This paper aims to report the anatomopathological and immunohistochemical findings of a clinical case of primary SCC in the trachea of a female Schnauzer canine, attended at the Veterinary Hospital Luiz Quintiliano de Oliveira of the Faculty of Veterinary Medicine of Araçatuba (FMVA – UNESP), presenting clinical signs such as choking, coughing and dyspnea for 1 month. The tracheal portion affected by the neoplasm was sent to the Veterinary Pathology department of the FMVA after surgical excision. Fragments of the neoplasm were collected and fixed in 10% formaldehyde for further histopathological and immunohistochemical analysis. Microscopically, the neoplasm was well differentiated, being characterized by the presence of keratin pearls, low degree of pleomorphism and rare mitotic figures. In the immunohistochemical analysis, there was immunoexpression of anti-cytokeratin antibodies AE1AE3, 34BE12, CK14 and CK5/6, confirming the diagnosis of squamous cell carcinoma. In about 30% of the cells there was immunostaining for Ki67 antibodies, justifying the low mitotic index of tumor cells and the few images of mitosis seen. Due to the rare occurrence of primary tracheal SCC in dogs, the use of diversified diagnostic techniques is important in order to better understand the biological behavior of this neoplasm in unusual anatomical locations.Hospital Veterinário Luiz Quintiliano de Oliveira FMVA-UNESP, SPUniversidade Brasil-Campus Fernandópolis, SPFMVZ-USP, SPFaculdade de Medicina Veterinária FMVA-UNESP, SPFaculdade de Ciências Agrárias e Veterinárias FCAV-UNESP, SPAutonomous veterinary, SPDepartment of Clinical Surgery and Animal Reproduction FMVA-UNESP, SPHospital Veterinário Luiz Quintiliano de Oliveira FMVA-UNESP, SPFaculdade de Medicina Veterinária FMVA-UNESP, SPFaculdade de Ciências Agrárias e Veterinárias FCAV-UNESP, SPDepartment of Clinical Surgery and Animal Reproduction FMVA-UNESP, SPUniversidade Estadual Paulista (UNESP)Universidade Brasil-Campus FernandópolisUniversidade de São Paulo (USP)Autonomous veterinaryde Lima, Bruno Medolago [UNESP]de Assis, Juliana ViegasPellissari, Maria Cecília Clarindo [UNESP]Manske, Luiza Raasch [UNESP]Roca, Tifany da Silva Sato [UNESP]de Alcântara, Brenda Mendonça [UNESP]Santos, Natália da SilvaPeres, Marina Lombardide Andrade, Alexandre Lima [UNESP]Machado, Gisele Fabrino [UNESP]Rozza, Daniela Bernadete [UNESP]2023-07-29T13:31:52Z2023-07-29T13:31:52Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article147-152http://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p147-152Brazilian Journal of Veterinary Pathology, v. 15, n. 3, p. 147-152, 2022.1983-0246http://hdl.handle.net/11449/24800510.24070/bjvp.1983-0246.v15i3p147-1522-s2.0-85143591485Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Pathologyinfo:eu-repo/semantics/openAccess2023-07-29T13:31:52Zoai:repositorio.unesp.br:11449/248005Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:31:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
title |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
spellingShingle |
Primary Tracheal Squamous Cells Carcinoma in a Dog de Lima, Bruno Medolago [UNESP] canine histopathology neoplasm |
title_short |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
title_full |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
title_fullStr |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
title_full_unstemmed |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
title_sort |
Primary Tracheal Squamous Cells Carcinoma in a Dog |
author |
de Lima, Bruno Medolago [UNESP] |
author_facet |
de Lima, Bruno Medolago [UNESP] de Assis, Juliana Viegas Pellissari, Maria Cecília Clarindo [UNESP] Manske, Luiza Raasch [UNESP] Roca, Tifany da Silva Sato [UNESP] de Alcântara, Brenda Mendonça [UNESP] Santos, Natália da Silva Peres, Marina Lombardi de Andrade, Alexandre Lima [UNESP] Machado, Gisele Fabrino [UNESP] Rozza, Daniela Bernadete [UNESP] |
author_role |
author |
author2 |
de Assis, Juliana Viegas Pellissari, Maria Cecília Clarindo [UNESP] Manske, Luiza Raasch [UNESP] Roca, Tifany da Silva Sato [UNESP] de Alcântara, Brenda Mendonça [UNESP] Santos, Natália da Silva Peres, Marina Lombardi de Andrade, Alexandre Lima [UNESP] Machado, Gisele Fabrino [UNESP] Rozza, Daniela Bernadete [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Brasil-Campus Fernandópolis Universidade de São Paulo (USP) Autonomous veterinary |
dc.contributor.author.fl_str_mv |
de Lima, Bruno Medolago [UNESP] de Assis, Juliana Viegas Pellissari, Maria Cecília Clarindo [UNESP] Manske, Luiza Raasch [UNESP] Roca, Tifany da Silva Sato [UNESP] de Alcântara, Brenda Mendonça [UNESP] Santos, Natália da Silva Peres, Marina Lombardi de Andrade, Alexandre Lima [UNESP] Machado, Gisele Fabrino [UNESP] Rozza, Daniela Bernadete [UNESP] |
dc.subject.por.fl_str_mv |
canine histopathology neoplasm |
topic |
canine histopathology neoplasm |
description |
Primary tracheal neoplasms are uncommon and poorly documented in veterinary medicine, being most frequently reported in domestic cats. Squamous cell carcinoma (SCC) is a malignant neoplasm that originates from the stratified squamous epithelium, considered one of the most common skin neoplasms in dogs and cats. This paper aims to report the anatomopathological and immunohistochemical findings of a clinical case of primary SCC in the trachea of a female Schnauzer canine, attended at the Veterinary Hospital Luiz Quintiliano de Oliveira of the Faculty of Veterinary Medicine of Araçatuba (FMVA – UNESP), presenting clinical signs such as choking, coughing and dyspnea for 1 month. The tracheal portion affected by the neoplasm was sent to the Veterinary Pathology department of the FMVA after surgical excision. Fragments of the neoplasm were collected and fixed in 10% formaldehyde for further histopathological and immunohistochemical analysis. Microscopically, the neoplasm was well differentiated, being characterized by the presence of keratin pearls, low degree of pleomorphism and rare mitotic figures. In the immunohistochemical analysis, there was immunoexpression of anti-cytokeratin antibodies AE1AE3, 34BE12, CK14 and CK5/6, confirming the diagnosis of squamous cell carcinoma. In about 30% of the cells there was immunostaining for Ki67 antibodies, justifying the low mitotic index of tumor cells and the few images of mitosis seen. Due to the rare occurrence of primary tracheal SCC in dogs, the use of diversified diagnostic techniques is important in order to better understand the biological behavior of this neoplasm in unusual anatomical locations. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:31:52Z 2023-07-29T13:31:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p147-152 Brazilian Journal of Veterinary Pathology, v. 15, n. 3, p. 147-152, 2022. 1983-0246 http://hdl.handle.net/11449/248005 10.24070/bjvp.1983-0246.v15i3p147-152 2-s2.0-85143591485 |
url |
http://dx.doi.org/10.24070/bjvp.1983-0246.v15i3p147-152 http://hdl.handle.net/11449/248005 |
identifier_str_mv |
Brazilian Journal of Veterinary Pathology, v. 15, n. 3, p. 147-152, 2022. 1983-0246 10.24070/bjvp.1983-0246.v15i3p147-152 2-s2.0-85143591485 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
147-152 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965739932712960 |