Decreased fertility in poor responder women is not related to oocyte morphological status
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5114/aoms.2011.22084 http://hdl.handle.net/11449/12209 |
Resumo: | Introduction: In women showing impaired fertility, a decreased response to ovarian stimulation is a major problem, limiting the number of oocytes to be used for assisted reproduction techniques (ART). Despite the several definitions of poor response, it is still a matter of debate whether young poor responder patients also show a decrease in oocyte quality. The objective in this study was to investigate whether poor ovarian response to the superstimulation protocol is accompanied by impaired oocyte quality.Material and methods: This study included 313 patients younger than 35 years old, undergoing intracytoplasmic sperm injection. Patients with four or fewer MII oocytes (poor-responder group, PR, n = 57) were age-matched with normoresponder patients (NR, n = 256).Results: A higher rate of oocyte retrieval and a trend towards an increase in MII oocyte rate were observed in the NR group when compared to the PR group (71.6 +/- 1.1% and 74.1 +/- 1.0% vs. 56.3 +/- 2.9% and 66.5 +/- 3.7%; p < 0.0001 and p = 0.056, respectively). A trend toward increased implantation rates was observed in the NR group when compared to the PR group (44 and 24.5 +/- 2.0% vs. 28.8 and 16.4 +/- 3.9%; p = 0.0305 and p = 0.0651, respectively).Conclusions: Low response to ovarian stimulation is apparently not related to impaired oocyte quality. However, embryos produced from poor responder oocytes show impaired capacity to implant and to carry a pregnancy to term. |
id |
UNSP_ab859339b53ea32e1b266356cf1e4fe3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/12209 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Decreased fertility in poor responder women is not related to oocyte morphological statusintracytoplasmic sperm injectionovarian stimulationoocyte retrievalIntroduction: In women showing impaired fertility, a decreased response to ovarian stimulation is a major problem, limiting the number of oocytes to be used for assisted reproduction techniques (ART). Despite the several definitions of poor response, it is still a matter of debate whether young poor responder patients also show a decrease in oocyte quality. The objective in this study was to investigate whether poor ovarian response to the superstimulation protocol is accompanied by impaired oocyte quality.Material and methods: This study included 313 patients younger than 35 years old, undergoing intracytoplasmic sperm injection. Patients with four or fewer MII oocytes (poor-responder group, PR, n = 57) were age-matched with normoresponder patients (NR, n = 256).Results: A higher rate of oocyte retrieval and a trend towards an increase in MII oocyte rate were observed in the NR group when compared to the PR group (71.6 +/- 1.1% and 74.1 +/- 1.0% vs. 56.3 +/- 2.9% and 66.5 +/- 3.7%; p < 0.0001 and p = 0.056, respectively). A trend toward increased implantation rates was observed in the NR group when compared to the PR group (44 and 24.5 +/- 2.0% vs. 28.8 and 16.4 +/- 3.9%; p = 0.0305 and p = 0.0651, respectively).Conclusions: Low response to ovarian stimulation is apparently not related to impaired oocyte quality. However, embryos produced from poor responder oocytes show impaired capacity to implant and to carry a pregnancy to term.Univ São Paulo, Dept Anim Reprod, Fac Vet Med, BR-05508 São Paulo, BrazilFertil Assisted Fertilizat Ctr, São Paulo, BrazilEduc & Res Ctr Assisted Reprod, Sapientiae Inst, São Paulo, BrazilUniv Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilUniv Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilTermedia Publishing House LtdUniversidade de São Paulo (USP)Fertil Assisted Fertilizat CtrEduc & Res Ctr Assisted ReprodUniversidade Estadual Paulista (Unesp)Nichi, MarcilioSavio Figueira, Rita de Cassiade Almeida Ferreira Braga, Daniela PaesSetti, Amanda SouzaIaconelli, AssumptoBorges, Edson [UNESP]2014-05-20T13:35:28Z2014-05-20T13:35:28Z2011-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article315-320http://dx.doi.org/10.5114/aoms.2011.22084Archives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 7, n. 2, p. 315-320, 2011.1734-1922http://hdl.handle.net/11449/1220910.5114/aoms.2011.22084WOS:000290915100019Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Medical Science2.3440,889info:eu-repo/semantics/openAccess2021-10-23T11:59:35Zoai:repositorio.unesp.br:11449/12209Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:59:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Decreased fertility in poor responder women is not related to oocyte morphological status |
title |
Decreased fertility in poor responder women is not related to oocyte morphological status |
spellingShingle |
Decreased fertility in poor responder women is not related to oocyte morphological status Nichi, Marcilio intracytoplasmic sperm injection ovarian stimulation oocyte retrieval |
title_short |
Decreased fertility in poor responder women is not related to oocyte morphological status |
title_full |
Decreased fertility in poor responder women is not related to oocyte morphological status |
title_fullStr |
Decreased fertility in poor responder women is not related to oocyte morphological status |
title_full_unstemmed |
Decreased fertility in poor responder women is not related to oocyte morphological status |
title_sort |
Decreased fertility in poor responder women is not related to oocyte morphological status |
author |
Nichi, Marcilio |
author_facet |
Nichi, Marcilio Savio Figueira, Rita de Cassia de Almeida Ferreira Braga, Daniela Paes Setti, Amanda Souza Iaconelli, Assumpto Borges, Edson [UNESP] |
author_role |
author |
author2 |
Savio Figueira, Rita de Cassia de Almeida Ferreira Braga, Daniela Paes Setti, Amanda Souza Iaconelli, Assumpto Borges, Edson [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Fertil Assisted Fertilizat Ctr Educ & Res Ctr Assisted Reprod Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nichi, Marcilio Savio Figueira, Rita de Cassia de Almeida Ferreira Braga, Daniela Paes Setti, Amanda Souza Iaconelli, Assumpto Borges, Edson [UNESP] |
dc.subject.por.fl_str_mv |
intracytoplasmic sperm injection ovarian stimulation oocyte retrieval |
topic |
intracytoplasmic sperm injection ovarian stimulation oocyte retrieval |
description |
Introduction: In women showing impaired fertility, a decreased response to ovarian stimulation is a major problem, limiting the number of oocytes to be used for assisted reproduction techniques (ART). Despite the several definitions of poor response, it is still a matter of debate whether young poor responder patients also show a decrease in oocyte quality. The objective in this study was to investigate whether poor ovarian response to the superstimulation protocol is accompanied by impaired oocyte quality.Material and methods: This study included 313 patients younger than 35 years old, undergoing intracytoplasmic sperm injection. Patients with four or fewer MII oocytes (poor-responder group, PR, n = 57) were age-matched with normoresponder patients (NR, n = 256).Results: A higher rate of oocyte retrieval and a trend towards an increase in MII oocyte rate were observed in the NR group when compared to the PR group (71.6 +/- 1.1% and 74.1 +/- 1.0% vs. 56.3 +/- 2.9% and 66.5 +/- 3.7%; p < 0.0001 and p = 0.056, respectively). A trend toward increased implantation rates was observed in the NR group when compared to the PR group (44 and 24.5 +/- 2.0% vs. 28.8 and 16.4 +/- 3.9%; p = 0.0305 and p = 0.0651, respectively).Conclusions: Low response to ovarian stimulation is apparently not related to impaired oocyte quality. However, embryos produced from poor responder oocytes show impaired capacity to implant and to carry a pregnancy to term. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04-01 2014-05-20T13:35:28Z 2014-05-20T13:35:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5114/aoms.2011.22084 Archives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 7, n. 2, p. 315-320, 2011. 1734-1922 http://hdl.handle.net/11449/12209 10.5114/aoms.2011.22084 WOS:000290915100019 |
url |
http://dx.doi.org/10.5114/aoms.2011.22084 http://hdl.handle.net/11449/12209 |
identifier_str_mv |
Archives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 7, n. 2, p. 315-320, 2011. 1734-1922 10.5114/aoms.2011.22084 WOS:000290915100019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Medical Science 2.344 0,889 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
315-320 |
dc.publisher.none.fl_str_mv |
Termedia Publishing House Ltd |
publisher.none.fl_str_mv |
Termedia Publishing House Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792961579887624192 |