Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-018-2773-7 http://hdl.handle.net/11449/188488 |
Resumo: | Objective: To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ. Methods: This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6×/day). Blocks were treated 3×/day with the following toothpastes: no F/HMP/HMPnano (Placebo), conventional fluoride toothpaste, 1100 ppm F (1100F), 1100F + 0.5% micrometric HMP (1100F/HMP), and 1100F + 0.5% nano-sized HMP (1100F/HMPnano). The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), and enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilms formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, followed by Student–Newman–Keuls’ test (p < 0.001). Results: 1100F/HMPnano promoted the lowest %SH and ΔKHN among all groups (p < 0.001). The addition of HMPnano to 1100F significantly increased Ca concentrations (p < 0.001). The 1100F/HMPnano promoted lower values of EPS when compared with 1100F (~ 70%) (p < 0.001) and higher values of fluoride and calcium in the biofilms (p < 0.001). Conclusion: 1100F/HMPnano demonstrated a greater protective effect against enamel demineralization and on the composition of biofilm in situ when compared to 1100F toothpaste. Clinical relevance: This toothpaste could be a viable alternative to patients at high risk of caries. |
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Anticaries effect of toothpaste with nano-sized sodium hexametaphosphateBiofilmCariesDemineralizationFluorideNano-sizedObjective: To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ. Methods: This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6×/day). Blocks were treated 3×/day with the following toothpastes: no F/HMP/HMPnano (Placebo), conventional fluoride toothpaste, 1100 ppm F (1100F), 1100F + 0.5% micrometric HMP (1100F/HMP), and 1100F + 0.5% nano-sized HMP (1100F/HMPnano). The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), and enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilms formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, followed by Student–Newman–Keuls’ test (p < 0.001). Results: 1100F/HMPnano promoted the lowest %SH and ΔKHN among all groups (p < 0.001). The addition of HMPnano to 1100F significantly increased Ca concentrations (p < 0.001). The 1100F/HMPnano promoted lower values of EPS when compared with 1100F (~ 70%) (p < 0.001) and higher values of fluoride and calcium in the biofilms (p < 0.001). Conclusion: 1100F/HMPnano demonstrated a greater protective effect against enamel demineralization and on the composition of biofilm in situ when compared to 1100F toothpaste. Clinical relevance: This toothpaste could be a viable alternative to patients at high risk of caries.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health São Paulo State University (UNESP), Rua José Bonifácio 1193LIEC-Department of Chemistry Federal University of São Carlos (UFSCar)School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health São Paulo State University (UNESP), Rua José Bonifácio 1193FAPESP: 2016/03148-7Universidade Estadual Paulista (Unesp)Universidade Federal de São Carlos (UFSCar)Garcia, Luhana Santos Gonzales [UNESP]Delbem, Alberto Carlos Botazzo [UNESP]Pessan, Juliano Pelim [UNESP]dos Passos Silva, Matheus [UNESP]Neto, Francisco Nunes SouzaGorup, Luiz Fernandode Camargo, Emerson RodriguesDanelon, Marcelle [UNESP]2019-10-06T16:09:49Z2019-10-06T16:09:49Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3535-3542http://dx.doi.org/10.1007/s00784-018-2773-7Clinical Oral Investigations, v. 23, n. 9, p. 3535-3542, 2019.1436-37711432-6981http://hdl.handle.net/11449/18848810.1007/s00784-018-2773-72-s2.0-85058399132Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigationsinfo:eu-repo/semantics/openAccess2021-10-23T19:28:28Zoai:repositorio.unesp.br:11449/188488Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:28:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
title |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
spellingShingle |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate Garcia, Luhana Santos Gonzales [UNESP] Biofilm Caries Demineralization Fluoride Nano-sized |
title_short |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
title_full |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
title_fullStr |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
title_full_unstemmed |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
title_sort |
Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate |
author |
Garcia, Luhana Santos Gonzales [UNESP] |
author_facet |
Garcia, Luhana Santos Gonzales [UNESP] Delbem, Alberto Carlos Botazzo [UNESP] Pessan, Juliano Pelim [UNESP] dos Passos Silva, Matheus [UNESP] Neto, Francisco Nunes Souza Gorup, Luiz Fernando de Camargo, Emerson Rodrigues Danelon, Marcelle [UNESP] |
author_role |
author |
author2 |
Delbem, Alberto Carlos Botazzo [UNESP] Pessan, Juliano Pelim [UNESP] dos Passos Silva, Matheus [UNESP] Neto, Francisco Nunes Souza Gorup, Luiz Fernando de Camargo, Emerson Rodrigues Danelon, Marcelle [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Garcia, Luhana Santos Gonzales [UNESP] Delbem, Alberto Carlos Botazzo [UNESP] Pessan, Juliano Pelim [UNESP] dos Passos Silva, Matheus [UNESP] Neto, Francisco Nunes Souza Gorup, Luiz Fernando de Camargo, Emerson Rodrigues Danelon, Marcelle [UNESP] |
dc.subject.por.fl_str_mv |
Biofilm Caries Demineralization Fluoride Nano-sized |
topic |
Biofilm Caries Demineralization Fluoride Nano-sized |
description |
Objective: To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ. Methods: This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6×/day). Blocks were treated 3×/day with the following toothpastes: no F/HMP/HMPnano (Placebo), conventional fluoride toothpaste, 1100 ppm F (1100F), 1100F + 0.5% micrometric HMP (1100F/HMP), and 1100F + 0.5% nano-sized HMP (1100F/HMPnano). The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), and enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilms formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, followed by Student–Newman–Keuls’ test (p < 0.001). Results: 1100F/HMPnano promoted the lowest %SH and ΔKHN among all groups (p < 0.001). The addition of HMPnano to 1100F significantly increased Ca concentrations (p < 0.001). The 1100F/HMPnano promoted lower values of EPS when compared with 1100F (~ 70%) (p < 0.001) and higher values of fluoride and calcium in the biofilms (p < 0.001). Conclusion: 1100F/HMPnano demonstrated a greater protective effect against enamel demineralization and on the composition of biofilm in situ when compared to 1100F toothpaste. Clinical relevance: This toothpaste could be a viable alternative to patients at high risk of caries. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:09:49Z 2019-10-06T16:09:49Z 2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-018-2773-7 Clinical Oral Investigations, v. 23, n. 9, p. 3535-3542, 2019. 1436-3771 1432-6981 http://hdl.handle.net/11449/188488 10.1007/s00784-018-2773-7 2-s2.0-85058399132 |
url |
http://dx.doi.org/10.1007/s00784-018-2773-7 http://hdl.handle.net/11449/188488 |
identifier_str_mv |
Clinical Oral Investigations, v. 23, n. 9, p. 3535-3542, 2019. 1436-3771 1432-6981 10.1007/s00784-018-2773-7 2-s2.0-85058399132 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3535-3542 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965486087143424 |