Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-018-2755-9 http://hdl.handle.net/11449/188436 |
Resumo: | Objectives: Studies have documented the anti-inflammatory effects of spices, which may be related to treatment of chronic diseases. The purpose of this study was to evaluate the influence of curcumin and piperine and their association on experimental periodontal repair in rats. Materials and methods: Periodontitis was induced via the installation of a ligature around the first molar. After 15 days, the ligatures were removed, and the rats were separated into groups (12 animals per group): (i) curcumin, (ii) piperine, (iii) curcumin+piperine, (iv) corn oil vehicle, and (v) control group (animals had ligature-induced periodontitis but were not treated). The compounds were administered daily, for 15 days by oral gavage. Animals were euthanized at 5 and 15 days, and hemimaxillae and gingival tissues were harvested. Bone repair was assessed by μCT (microcomputer tomography). Histological sections were stained with hematoxylin/eosin (H/E) for the assessment of cellular infiltrate or picrosirius red for quantification of collagen content, and subjected to immunohistochemistry for detecting NF-ĸB. Gingival tissues were used to evaluate levels of TGF-β and IL-10 (ELISA). Results: Curcumin and piperine increased the TGF-β level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-ĸB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair. Conclusion: Curcumin and piperine promoted a substantive effect on tissue repair; however, there was not synergistic effect of compounds administered in combination. Clinical relevance: Curcumin and piperine stimulates the tissue repair and may be potential candidates for the treatment of periodontal disease. |
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Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in ratsCurcuminPeriodontal diseasePiperineRatsRepairObjectives: Studies have documented the anti-inflammatory effects of spices, which may be related to treatment of chronic diseases. The purpose of this study was to evaluate the influence of curcumin and piperine and their association on experimental periodontal repair in rats. Materials and methods: Periodontitis was induced via the installation of a ligature around the first molar. After 15 days, the ligatures were removed, and the rats were separated into groups (12 animals per group): (i) curcumin, (ii) piperine, (iii) curcumin+piperine, (iv) corn oil vehicle, and (v) control group (animals had ligature-induced periodontitis but were not treated). The compounds were administered daily, for 15 days by oral gavage. Animals were euthanized at 5 and 15 days, and hemimaxillae and gingival tissues were harvested. Bone repair was assessed by μCT (microcomputer tomography). Histological sections were stained with hematoxylin/eosin (H/E) for the assessment of cellular infiltrate or picrosirius red for quantification of collagen content, and subjected to immunohistochemistry for detecting NF-ĸB. Gingival tissues were used to evaluate levels of TGF-β and IL-10 (ELISA). Results: Curcumin and piperine increased the TGF-β level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-ĸB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair. Conclusion: Curcumin and piperine promoted a substantive effect on tissue repair; however, there was not synergistic effect of compounds administered in combination. Clinical relevance: Curcumin and piperine stimulates the tissue repair and may be potential candidates for the treatment of periodontal disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Diagnosis and Surgery School of Dentistry at Araraquara - Univ Estadual Paulista (UNESP), Rua Humaita, 1680 – CentroDepartment of Clinical and Social Dentistry- Health Science Center Federal University of ParaíbaDepartment of Histology and Embriology School of Dentistry at Araraquara UNESPDepartment of Stomatology School of Dentistry-University of Sao Paulo (USP)Department of Diagnosis and Surgery School of Dentistry at Araraquara - Univ Estadual Paulista (UNESP), Rua Humaita, 1680 – CentroDepartment of Histology and Embriology School of Dentistry at Araraquara UNESPFAPESP: 2010/19660-2Universidade Estadual Paulista (Unesp)Federal University of ParaíbaUniversidade de São Paulo (USP)Guimaraes-Stabili, Morgana R. [UNESP]de Aquino, Sabrina Garciade Almeida Curylofo, Fabiana [UNESP]Tasso, Camilla Olga [UNESP]Rocha, Fernanda Regina Godoy [UNESP]de Medeiros, Marcell Costa [UNESP]de Pizzol, José Paulo [UNESP]Cerri, Paulo Sérgio [UNESP]Romito, Giuseppe AlexandreRossa, Carlos [UNESP]2019-10-06T16:07:58Z2019-10-06T16:07:58Z2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3297-3306http://dx.doi.org/10.1007/s00784-018-2755-9Clinical Oral Investigations, v. 23, n. 8, p. 3297-3306, 2019.1436-37711432-6981http://hdl.handle.net/11449/18843610.1007/s00784-018-2755-92-s2.0-8505760402532784959112078820000-0001-5756-5828Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigationsinfo:eu-repo/semantics/openAccess2021-10-23T14:48:06Zoai:repositorio.unesp.br:11449/188436Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T14:48:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
title |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
spellingShingle |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats Guimaraes-Stabili, Morgana R. [UNESP] Curcumin Periodontal disease Piperine Rats Repair |
title_short |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
title_full |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
title_fullStr |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
title_full_unstemmed |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
title_sort |
Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats |
author |
Guimaraes-Stabili, Morgana R. [UNESP] |
author_facet |
Guimaraes-Stabili, Morgana R. [UNESP] de Aquino, Sabrina Garcia de Almeida Curylofo, Fabiana [UNESP] Tasso, Camilla Olga [UNESP] Rocha, Fernanda Regina Godoy [UNESP] de Medeiros, Marcell Costa [UNESP] de Pizzol, José Paulo [UNESP] Cerri, Paulo Sérgio [UNESP] Romito, Giuseppe Alexandre Rossa, Carlos [UNESP] |
author_role |
author |
author2 |
de Aquino, Sabrina Garcia de Almeida Curylofo, Fabiana [UNESP] Tasso, Camilla Olga [UNESP] Rocha, Fernanda Regina Godoy [UNESP] de Medeiros, Marcell Costa [UNESP] de Pizzol, José Paulo [UNESP] Cerri, Paulo Sérgio [UNESP] Romito, Giuseppe Alexandre Rossa, Carlos [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Paraíba Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Guimaraes-Stabili, Morgana R. [UNESP] de Aquino, Sabrina Garcia de Almeida Curylofo, Fabiana [UNESP] Tasso, Camilla Olga [UNESP] Rocha, Fernanda Regina Godoy [UNESP] de Medeiros, Marcell Costa [UNESP] de Pizzol, José Paulo [UNESP] Cerri, Paulo Sérgio [UNESP] Romito, Giuseppe Alexandre Rossa, Carlos [UNESP] |
dc.subject.por.fl_str_mv |
Curcumin Periodontal disease Piperine Rats Repair |
topic |
Curcumin Periodontal disease Piperine Rats Repair |
description |
Objectives: Studies have documented the anti-inflammatory effects of spices, which may be related to treatment of chronic diseases. The purpose of this study was to evaluate the influence of curcumin and piperine and their association on experimental periodontal repair in rats. Materials and methods: Periodontitis was induced via the installation of a ligature around the first molar. After 15 days, the ligatures were removed, and the rats were separated into groups (12 animals per group): (i) curcumin, (ii) piperine, (iii) curcumin+piperine, (iv) corn oil vehicle, and (v) control group (animals had ligature-induced periodontitis but were not treated). The compounds were administered daily, for 15 days by oral gavage. Animals were euthanized at 5 and 15 days, and hemimaxillae and gingival tissues were harvested. Bone repair was assessed by μCT (microcomputer tomography). Histological sections were stained with hematoxylin/eosin (H/E) for the assessment of cellular infiltrate or picrosirius red for quantification of collagen content, and subjected to immunohistochemistry for detecting NF-ĸB. Gingival tissues were used to evaluate levels of TGF-β and IL-10 (ELISA). Results: Curcumin and piperine increased the TGF-β level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-ĸB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair. Conclusion: Curcumin and piperine promoted a substantive effect on tissue repair; however, there was not synergistic effect of compounds administered in combination. Clinical relevance: Curcumin and piperine stimulates the tissue repair and may be potential candidates for the treatment of periodontal disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:07:58Z 2019-10-06T16:07:58Z 2019-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-018-2755-9 Clinical Oral Investigations, v. 23, n. 8, p. 3297-3306, 2019. 1436-3771 1432-6981 http://hdl.handle.net/11449/188436 10.1007/s00784-018-2755-9 2-s2.0-85057604025 3278495911207882 0000-0001-5756-5828 |
url |
http://dx.doi.org/10.1007/s00784-018-2755-9 http://hdl.handle.net/11449/188436 |
identifier_str_mv |
Clinical Oral Investigations, v. 23, n. 8, p. 3297-3306, 2019. 1436-3771 1432-6981 10.1007/s00784-018-2755-9 2-s2.0-85057604025 3278495911207882 0000-0001-5756-5828 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3297-3306 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789719185063936 |