New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/pathogens9010030 http://hdl.handle.net/11449/195194 |
Resumo: | Coxiella burnetii, the zoonotic agent of Q fever, has a worldwide distribution. Despite the vast information about the circulating genotypes in Europe and North America, there is a lack of data regarding C. burnetii strains in South America. Here, we show the presence of novel multispacer sequence typing (MST) genotypes of C. burnetii in two clusters detected in Brazil and Argentina that seem to be distant in parenthood. Argentinian strains isolated from a tick belongs to a new phylogenetic branch of C. burnetii, and the Brazilians strains may be related to MST 20 and 61. Multilocus variable number tandem repeats analysis (MLVA) typing provided a deeper resolution that may be related to host clusters of bovines, caprine, ovine, and ticks. Our results corroborate with the reports of geotypes of C. burnetii. Thus, we highlight the need for more genotyping studies to understand the genetic diversity of C. burnetii in South America and to confirm the hypothesis of host-related genotypes. We also emphasize the importance of virulence studies for a better understanding of Q fever in the region, which may help in surveillance and disease prevention programs. |
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New Genotypes of Coxiella burnetii Circulating in Brazil and ArgentinaCoxiella burnetiiQ fevermultilocus sequence typing (MST)tandem repeatsequencesCoxiella burnetii, the zoonotic agent of Q fever, has a worldwide distribution. Despite the vast information about the circulating genotypes in Europe and North America, there is a lack of data regarding C. burnetii strains in South America. Here, we show the presence of novel multispacer sequence typing (MST) genotypes of C. burnetii in two clusters detected in Brazil and Argentina that seem to be distant in parenthood. Argentinian strains isolated from a tick belongs to a new phylogenetic branch of C. burnetii, and the Brazilians strains may be related to MST 20 and 61. Multilocus variable number tandem repeats analysis (MLVA) typing provided a deeper resolution that may be related to host clusters of bovines, caprine, ovine, and ticks. Our results corroborate with the reports of geotypes of C. burnetii. Thus, we highlight the need for more genotyping studies to understand the genetic diversity of C. burnetii in South America and to confirm the hypothesis of host-related genotypes. We also emphasize the importance of virulence studies for a better understanding of Q fever in the region, which may help in surveillance and disease prevention programs.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Dept Higiene Vet & Saude Publ, BR-18610000 Sao Paulo, BrazilAgence Natl Securite Sanitaire Alimentat Environm, F-06902 Sophia, Antipolis, FranceUniv Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, BrazilUniv Sao Paulo, Dept Med Vet Prevent & Saude Anim, BR-05508270 Sao Paulo, BrazilUniv Estadual Paulista, Dept Higiene Vet & Saude Publ, BR-18610000 Sao Paulo, BrazilCAPES: 88887.137563/2017-00CAPES: 88882.180556/2018-01MdpiUniversidade Estadual Paulista (Unesp)Agence Natl Securite Sanitaire Alimentat EnvironmUniversidade de São Paulo (USP)Ribeiro Mioni, Mateus de Souza [UNESP]Sidi-Boumedine, KarimDalanezi, Felipe Morales [UNESP]Joaquim, Samea Fernandes [UNESP]Denadai, Renan [UNESP]Reis Teixeira, Wanderson Sirley [UNESP]Labruna, Marcelo BahiaMegid, Jane [UNESP]2020-12-10T17:07:40Z2020-12-10T17:07:40Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11http://dx.doi.org/10.3390/pathogens9010030Pathogens. Basel: Mdpi, v. 9, n. 1, 11 p., 2020.http://hdl.handle.net/11449/19519410.3390/pathogens9010030WOS:000513130300065Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPathogensinfo:eu-repo/semantics/openAccess2021-10-22T21:54:22Zoai:repositorio.unesp.br:11449/195194Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T21:54:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
title |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
spellingShingle |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina Ribeiro Mioni, Mateus de Souza [UNESP] Coxiella burnetii Q fever multilocus sequence typing (MST) tandem repeatsequences |
title_short |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
title_full |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
title_fullStr |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
title_full_unstemmed |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
title_sort |
New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina |
author |
Ribeiro Mioni, Mateus de Souza [UNESP] |
author_facet |
Ribeiro Mioni, Mateus de Souza [UNESP] Sidi-Boumedine, Karim Dalanezi, Felipe Morales [UNESP] Joaquim, Samea Fernandes [UNESP] Denadai, Renan [UNESP] Reis Teixeira, Wanderson Sirley [UNESP] Labruna, Marcelo Bahia Megid, Jane [UNESP] |
author_role |
author |
author2 |
Sidi-Boumedine, Karim Dalanezi, Felipe Morales [UNESP] Joaquim, Samea Fernandes [UNESP] Denadai, Renan [UNESP] Reis Teixeira, Wanderson Sirley [UNESP] Labruna, Marcelo Bahia Megid, Jane [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Agence Natl Securite Sanitaire Alimentat Environm Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ribeiro Mioni, Mateus de Souza [UNESP] Sidi-Boumedine, Karim Dalanezi, Felipe Morales [UNESP] Joaquim, Samea Fernandes [UNESP] Denadai, Renan [UNESP] Reis Teixeira, Wanderson Sirley [UNESP] Labruna, Marcelo Bahia Megid, Jane [UNESP] |
dc.subject.por.fl_str_mv |
Coxiella burnetii Q fever multilocus sequence typing (MST) tandem repeatsequences |
topic |
Coxiella burnetii Q fever multilocus sequence typing (MST) tandem repeatsequences |
description |
Coxiella burnetii, the zoonotic agent of Q fever, has a worldwide distribution. Despite the vast information about the circulating genotypes in Europe and North America, there is a lack of data regarding C. burnetii strains in South America. Here, we show the presence of novel multispacer sequence typing (MST) genotypes of C. burnetii in two clusters detected in Brazil and Argentina that seem to be distant in parenthood. Argentinian strains isolated from a tick belongs to a new phylogenetic branch of C. burnetii, and the Brazilians strains may be related to MST 20 and 61. Multilocus variable number tandem repeats analysis (MLVA) typing provided a deeper resolution that may be related to host clusters of bovines, caprine, ovine, and ticks. Our results corroborate with the reports of geotypes of C. burnetii. Thus, we highlight the need for more genotyping studies to understand the genetic diversity of C. burnetii in South America and to confirm the hypothesis of host-related genotypes. We also emphasize the importance of virulence studies for a better understanding of Q fever in the region, which may help in surveillance and disease prevention programs. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T17:07:40Z 2020-12-10T17:07:40Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/pathogens9010030 Pathogens. Basel: Mdpi, v. 9, n. 1, 11 p., 2020. http://hdl.handle.net/11449/195194 10.3390/pathogens9010030 WOS:000513130300065 |
url |
http://dx.doi.org/10.3390/pathogens9010030 http://hdl.handle.net/11449/195194 |
identifier_str_mv |
Pathogens. Basel: Mdpi, v. 9, n. 1, 11 p., 2020. 10.3390/pathogens9010030 WOS:000513130300065 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pathogens |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 |
dc.publisher.none.fl_str_mv |
Mdpi |
publisher.none.fl_str_mv |
Mdpi |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789892854415360 |