Involvement of dopamine receptors in diethylpropion-induced conditioning place preference
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X1998000400014 http://hdl.handle.net/11449/8088 |
Resumo: | Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. After initial preferences were determined, animals weighing 250-300 g (N = 7 per group) were conditioned with DEP (10, 15 or 20 mg/kg). Only the dose of 15 mg/kg produced a significant place preference (358 ± 39 vs 565 ± 48 s). Pretreatment with the D1 antagonist SCH 23390 (0.05 mg/kg, sc) 10 min before DEP (15 mg/kg, ip) blocked DEP-induced CPP (418 ± 37 vs 389 ± 31 s) while haloperidol (0.5 mg/kg, ip), a D2 antagonist, 15 min before DEP was ineffective in modifying place conditioning produced by DEP (385 ± 36 vs 536 ± 41 s). These results suggest that dopamine D1 receptors mediate the reinforcing effect of DEP |
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Repositório Institucional da UNESP |
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2946 |
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Involvement of dopamine receptors in diethylpropion-induced conditioning place preferencediethylpropionconditioning place preferencereinforcing effectdopamine receptorsDiethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. After initial preferences were determined, animals weighing 250-300 g (N = 7 per group) were conditioned with DEP (10, 15 or 20 mg/kg). Only the dose of 15 mg/kg produced a significant place preference (358 ± 39 vs 565 ± 48 s). Pretreatment with the D1 antagonist SCH 23390 (0.05 mg/kg, sc) 10 min before DEP (15 mg/kg, ip) blocked DEP-induced CPP (418 ± 37 vs 389 ± 31 s) while haloperidol (0.5 mg/kg, ip), a D2 antagonist, 15 min before DEP was ineffective in modifying place conditioning produced by DEP (385 ± 36 vs 536 ± 41 s). These results suggest that dopamine D1 receptors mediate the reinforcing effect of DEPUniversidade Estadual PaulistaUniversidade de São PauloUniversidade Estadual PaulistaAssociação Brasileira de Divulgação Científica (ABRADIC)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Planeta, Cleopatra da Silva [UNESP]DeLucia, R.2014-05-20T13:25:31Z2014-05-20T13:25:31Z1998-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article561-564application/pdfhttp://dx.doi.org/10.1590/S0100-879X1998000400014Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 4, p. 561-564, 1998.0100-879Xhttp://hdl.handle.net/11449/808810.1590/S0100-879X1998000400014S0100-879X1998000400014S0100-879X1998000400014.pdf25147625452809420000-0002-1378-6327SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2023-12-30T06:14:43Zoai:repositorio.unesp.br:11449/8088Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-30T06:14:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
title |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
spellingShingle |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference Planeta, Cleopatra da Silva [UNESP] diethylpropion conditioning place preference reinforcing effect dopamine receptors |
title_short |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
title_full |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
title_fullStr |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
title_full_unstemmed |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
title_sort |
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference |
author |
Planeta, Cleopatra da Silva [UNESP] |
author_facet |
Planeta, Cleopatra da Silva [UNESP] DeLucia, R. |
author_role |
author |
author2 |
DeLucia, R. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Planeta, Cleopatra da Silva [UNESP] DeLucia, R. |
dc.subject.por.fl_str_mv |
diethylpropion conditioning place preference reinforcing effect dopamine receptors |
topic |
diethylpropion conditioning place preference reinforcing effect dopamine receptors |
description |
Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. After initial preferences were determined, animals weighing 250-300 g (N = 7 per group) were conditioned with DEP (10, 15 or 20 mg/kg). Only the dose of 15 mg/kg produced a significant place preference (358 ± 39 vs 565 ± 48 s). Pretreatment with the D1 antagonist SCH 23390 (0.05 mg/kg, sc) 10 min before DEP (15 mg/kg, ip) blocked DEP-induced CPP (418 ± 37 vs 389 ± 31 s) while haloperidol (0.5 mg/kg, ip), a D2 antagonist, 15 min before DEP was ineffective in modifying place conditioning produced by DEP (385 ± 36 vs 536 ± 41 s). These results suggest that dopamine D1 receptors mediate the reinforcing effect of DEP |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-04-01 2014-05-20T13:25:31Z 2014-05-20T13:25:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1998000400014 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 4, p. 561-564, 1998. 0100-879X http://hdl.handle.net/11449/8088 10.1590/S0100-879X1998000400014 S0100-879X1998000400014 S0100-879X1998000400014.pdf 2514762545280942 0000-0002-1378-6327 |
url |
http://dx.doi.org/10.1590/S0100-879X1998000400014 http://hdl.handle.net/11449/8088 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 4, p. 561-564, 1998. 0100-879X 10.1590/S0100-879X1998000400014 S0100-879X1998000400014 S0100-879X1998000400014.pdf 2514762545280942 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research 1.492 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
561-564 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965451465261056 |