Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-5150-PVB-7124 http://hdl.handle.net/11449/248649 |
Resumo: | Cutaneous lymphomas are uncommon tumors in dogs that can occur as epitheliotropic and non-epitheliotropic types. The epitheliotropic type comprises three, already well established, distinct clinicopathological presentations. However, the non-epitheliotropic lymphoma, despite its poor characterization, represents a heterogeneous group of not yet correlated presentations that can mimic different skin tumors, configuring a diagnostic challenge. Therefore, this study’s main aim was to establish whether there is a correlation between the macroscopic presentation and the histological subtypes of cutaneous non-epitheliotropic lymphoma in the population of dogs involved in this study. Additionally, we aimed to determine the prevalence of each type and histological subtype of canine cutaneous lymphoma and describe the epidemiological and anatomopathological characteristics of the presented cases. From a total of 38 cases of cutaneous lymphoma diagnosed in dogs, 17 (44.7%) were considered as epitheliotropic and 21 (55.3%) as non-epitheliotropic. From the 17 cases of cutaneous epitheliotropic lymphoma, 13 (34.2%) and four (10.5%) were subclassified as mycosis fungoides and pagetoid reticulosis, respectively. The cases of cutaneous non-epitheliotropic lymphoma included were: anaplastic large T-cell lymphoma (ALTCL – 9/21, 23.9%), peripheral T-cell lymphoma, unspecified (PTCL-NOS – 4/21, 10.5%), subcutaneous panniculitis-like T-cell lymphoma (SPTCL – 4/21, 10.5%), diffuse large B-cell lymphoma – immunoblastic type (DLBCL – 2/21, 5.2%), lymphomatoid granulomatosis (LYG – 1/21, 2.6%), and marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) - lymphoplasmacytic variant (1/21, 2.6%). Based on the anatomopathological findings, it was possible to infer that when faced with multiple, nodular or placoid skin lesions, predominantly on the trunk and limbs, the diagnosis is more likely to be consistent with ALTCL. Whereas, with solitary skin nodules or plaques, PTCL-NOS will be the most frequently observed histological type. When these lesions are exclusively located in the subcutaneous tissue, one should first think about SPTCL and, more rarely, DLBCL. Regarding to epitheliotropic cutaneous lymphomas, the most commonly observed type in dogs is the cutaneous form of mycosis fungoides, especially in the pre-mycotic and mycotic phases. We hope that this information can assist veterinary clinicians and pathologists in their diagnostic routines and contribute to the characterization of non-epitheliotropic cutaneous lymphomas in the canine species. |
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Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogscutaneous tumorsdermatopathologydogsSkin lymphomasuncommon lymphomasCutaneous lymphomas are uncommon tumors in dogs that can occur as epitheliotropic and non-epitheliotropic types. The epitheliotropic type comprises three, already well established, distinct clinicopathological presentations. However, the non-epitheliotropic lymphoma, despite its poor characterization, represents a heterogeneous group of not yet correlated presentations that can mimic different skin tumors, configuring a diagnostic challenge. Therefore, this study’s main aim was to establish whether there is a correlation between the macroscopic presentation and the histological subtypes of cutaneous non-epitheliotropic lymphoma in the population of dogs involved in this study. Additionally, we aimed to determine the prevalence of each type and histological subtype of canine cutaneous lymphoma and describe the epidemiological and anatomopathological characteristics of the presented cases. From a total of 38 cases of cutaneous lymphoma diagnosed in dogs, 17 (44.7%) were considered as epitheliotropic and 21 (55.3%) as non-epitheliotropic. From the 17 cases of cutaneous epitheliotropic lymphoma, 13 (34.2%) and four (10.5%) were subclassified as mycosis fungoides and pagetoid reticulosis, respectively. The cases of cutaneous non-epitheliotropic lymphoma included were: anaplastic large T-cell lymphoma (ALTCL – 9/21, 23.9%), peripheral T-cell lymphoma, unspecified (PTCL-NOS – 4/21, 10.5%), subcutaneous panniculitis-like T-cell lymphoma (SPTCL – 4/21, 10.5%), diffuse large B-cell lymphoma – immunoblastic type (DLBCL – 2/21, 5.2%), lymphomatoid granulomatosis (LYG – 1/21, 2.6%), and marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) - lymphoplasmacytic variant (1/21, 2.6%). Based on the anatomopathological findings, it was possible to infer that when faced with multiple, nodular or placoid skin lesions, predominantly on the trunk and limbs, the diagnosis is more likely to be consistent with ALTCL. Whereas, with solitary skin nodules or plaques, PTCL-NOS will be the most frequently observed histological type. When these lesions are exclusively located in the subcutaneous tissue, one should first think about SPTCL and, more rarely, DLBCL. Regarding to epitheliotropic cutaneous lymphomas, the most commonly observed type in dogs is the cutaneous form of mycosis fungoides, especially in the pre-mycotic and mycotic phases. We hope that this information can assist veterinary clinicians and pathologists in their diagnostic routines and contribute to the characterization of non-epitheliotropic cutaneous lymphomas in the canine species.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Programa de Pós-graduação em Medicina Veterinária área de concentração em Patologia e Patologia Clínica Veterinária Centro de Ciências Rurais (CCR) Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Camobi, RSVeterinarian, Rua Conde de Irajá 420, BotafogoAxys Análises – Diagnóstico Veterinário e Consultoria Ltda., Rua Alberto Silva 332, Vila IpirangaVeterinarian, Rua Bolívia 575, São PedroLaboratório de Histopatologia Veterinária (LHV) Faculdade de Ciências Agrárias e Veterinárias Departamento de Patologia Reprodução e Saúde Única Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Via de Acesso Prof. Paulo Donato s/nLaboratório de Patologia Animal (LPA) Hospital Veterinário Universitário Centro de Saúde e Tecnologia Rural (CSTR) Universidade Federal de Campina Grande (UFCG), Av. Universitária s/n, Santa CecíliaCélula – Laboratório Veterinário, Rua Castro Alves 398, CentroLaboratório de Patologia Morfológica e Molecular (LAPMOL) Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade de São Paulo (USP) Cidade Universitária, Avenida Prof. Dr. Orlando Marques de Paiva 87Centro Clínico e Cirúrgico Veterinário (CCCV), Rua Gonçalves Chaves 4806, CentroDepartamento de Patologia Centro de Ciências da Saúde Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, CamobiLaboratório de Histopatologia Veterinária (LHV) Faculdade de Ciências Agrárias e Veterinárias Departamento de Patologia Reprodução e Saúde Única Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Via de Acesso Prof. Paulo Donato s/nUniversidade Federal de Sergipe (UFS)VeterinarianAxys Análises – Diagnóstico Veterinário e Consultoria Ltda.Universidade Estadual Paulista (UNESP)Universidade Federal de Campina Grande (UFCG)Célula – Laboratório VeterinárioUniversidade de São Paulo (USP)Centro Clínico e Cirúrgico Veterinário (CCCV)Mazaro, Renata D.Lorenzetti, Douglas M.Leite, Suzana M.G.Masuda, Eduardo K.Da Costa, Leonardo D.Vasconcelos, Rosemeri O. [UNESP]Dantas, Antonio Flávio M.Lacerda, Luciana C.Da Silva, Tereza CristinaMotta, Marco Aurélio A.Cogliati, BrunoFighera, Rafael A.2023-07-29T13:49:52Z2023-07-29T13:49:52Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1678-5150-PVB-7124Pesquisa Veterinaria Brasileira, v. 43.1678-51500100-736Xhttp://hdl.handle.net/11449/24864910.1590/1678-5150-PVB-71242-s2.0-85151821840Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-07-29T13:49:52Zoai:repositorio.unesp.br:11449/248649Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:49:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
title |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
spellingShingle |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs Mazaro, Renata D. cutaneous tumors dermatopathology dogs Skin lymphomas uncommon lymphomas |
title_short |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
title_full |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
title_fullStr |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
title_full_unstemmed |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
title_sort |
Epidemiological, anatomopathological, and immunophenotypical aspects of cutaneous lymphomas in dogs |
author |
Mazaro, Renata D. |
author_facet |
Mazaro, Renata D. Lorenzetti, Douglas M. Leite, Suzana M.G. Masuda, Eduardo K. Da Costa, Leonardo D. Vasconcelos, Rosemeri O. [UNESP] Dantas, Antonio Flávio M. Lacerda, Luciana C. Da Silva, Tereza Cristina Motta, Marco Aurélio A. Cogliati, Bruno Fighera, Rafael A. |
author_role |
author |
author2 |
Lorenzetti, Douglas M. Leite, Suzana M.G. Masuda, Eduardo K. Da Costa, Leonardo D. Vasconcelos, Rosemeri O. [UNESP] Dantas, Antonio Flávio M. Lacerda, Luciana C. Da Silva, Tereza Cristina Motta, Marco Aurélio A. Cogliati, Bruno Fighera, Rafael A. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Veterinarian Axys Análises – Diagnóstico Veterinário e Consultoria Ltda. Universidade Estadual Paulista (UNESP) Universidade Federal de Campina Grande (UFCG) Célula – Laboratório Veterinário Universidade de São Paulo (USP) Centro Clínico e Cirúrgico Veterinário (CCCV) |
dc.contributor.author.fl_str_mv |
Mazaro, Renata D. Lorenzetti, Douglas M. Leite, Suzana M.G. Masuda, Eduardo K. Da Costa, Leonardo D. Vasconcelos, Rosemeri O. [UNESP] Dantas, Antonio Flávio M. Lacerda, Luciana C. Da Silva, Tereza Cristina Motta, Marco Aurélio A. Cogliati, Bruno Fighera, Rafael A. |
dc.subject.por.fl_str_mv |
cutaneous tumors dermatopathology dogs Skin lymphomas uncommon lymphomas |
topic |
cutaneous tumors dermatopathology dogs Skin lymphomas uncommon lymphomas |
description |
Cutaneous lymphomas are uncommon tumors in dogs that can occur as epitheliotropic and non-epitheliotropic types. The epitheliotropic type comprises three, already well established, distinct clinicopathological presentations. However, the non-epitheliotropic lymphoma, despite its poor characterization, represents a heterogeneous group of not yet correlated presentations that can mimic different skin tumors, configuring a diagnostic challenge. Therefore, this study’s main aim was to establish whether there is a correlation between the macroscopic presentation and the histological subtypes of cutaneous non-epitheliotropic lymphoma in the population of dogs involved in this study. Additionally, we aimed to determine the prevalence of each type and histological subtype of canine cutaneous lymphoma and describe the epidemiological and anatomopathological characteristics of the presented cases. From a total of 38 cases of cutaneous lymphoma diagnosed in dogs, 17 (44.7%) were considered as epitheliotropic and 21 (55.3%) as non-epitheliotropic. From the 17 cases of cutaneous epitheliotropic lymphoma, 13 (34.2%) and four (10.5%) were subclassified as mycosis fungoides and pagetoid reticulosis, respectively. The cases of cutaneous non-epitheliotropic lymphoma included were: anaplastic large T-cell lymphoma (ALTCL – 9/21, 23.9%), peripheral T-cell lymphoma, unspecified (PTCL-NOS – 4/21, 10.5%), subcutaneous panniculitis-like T-cell lymphoma (SPTCL – 4/21, 10.5%), diffuse large B-cell lymphoma – immunoblastic type (DLBCL – 2/21, 5.2%), lymphomatoid granulomatosis (LYG – 1/21, 2.6%), and marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) - lymphoplasmacytic variant (1/21, 2.6%). Based on the anatomopathological findings, it was possible to infer that when faced with multiple, nodular or placoid skin lesions, predominantly on the trunk and limbs, the diagnosis is more likely to be consistent with ALTCL. Whereas, with solitary skin nodules or plaques, PTCL-NOS will be the most frequently observed histological type. When these lesions are exclusively located in the subcutaneous tissue, one should first think about SPTCL and, more rarely, DLBCL. Regarding to epitheliotropic cutaneous lymphomas, the most commonly observed type in dogs is the cutaneous form of mycosis fungoides, especially in the pre-mycotic and mycotic phases. We hope that this information can assist veterinary clinicians and pathologists in their diagnostic routines and contribute to the characterization of non-epitheliotropic cutaneous lymphomas in the canine species. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:49:52Z 2023-07-29T13:49:52Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-5150-PVB-7124 Pesquisa Veterinaria Brasileira, v. 43. 1678-5150 0100-736X http://hdl.handle.net/11449/248649 10.1590/1678-5150-PVB-7124 2-s2.0-85151821840 |
url |
http://dx.doi.org/10.1590/1678-5150-PVB-7124 http://hdl.handle.net/11449/248649 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 43. 1678-5150 0100-736X 10.1590/1678-5150-PVB-7124 2-s2.0-85151821840 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964686069792768 |