Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/0361073X.2022.2048586 http://hdl.handle.net/11449/223597 |
Resumo: | Objective: to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer’s Disease (AD) patients. Methods: 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18–Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. Results: After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Conclusion: Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients. |
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Repositório Institucional da UNESP |
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spelling |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled TrialObjective: to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer’s Disease (AD) patients. Methods: 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18–Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. Results: After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Conclusion: Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients.The Human Performance Research Group UTFPR: Universidade Tecnológica Federal do Paraná, PRPostgraduate Program in Physical Education UFTM Universidade Federal do Triangulo MineiroInstituto Federal do Triângulo Mineiro, MGDepartment of Pharmacology Biomedical Sciences Institute USP: Universidade de Sao PauloInstitute of Biosciences UNESP: Universidade Estadual Paulista Julio de Mesquita Filho, SPInstitute of Psychiatry UFRJ Universidade Federal do Rio de Janeiro, RJCenter of Mathematics Computing and Cognition UFABC Universidade Federal do ABC, SPUfabc: Universidade Federal Do AbcInstitute of Biosciences UNESP: Universidade Estadual Paulista Julio de Mesquita Filho, SPUTFPR: Universidade Tecnológica Federal do ParanáUniversidade Federal do Triangulo MineiroInstituto Federal do Triângulo MineiroUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Universidade Federal do Rio de Janeiro (UFRJ)Universidade Federal do ABC (UFABC)Stein, Angelica MikiCoelho, Flávia Gomes de MeloVital-Silva, Thays Martins [UNESP]Rueda, André VelosoPereira, Jessica RodriguesDeslandes, Andréa CamazCamarini, RosanaSantos Galduróz, Ruth Ferreira2022-04-28T19:51:33Z2022-04-28T19:51:33Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/0361073X.2022.2048586Experimental Aging Research.1096-46570361-073Xhttp://hdl.handle.net/11449/22359710.1080/0361073X.2022.20485862-s2.0-85126030403Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Aging Researchinfo:eu-repo/semantics/openAccess2022-04-28T19:51:33Zoai:repositorio.unesp.br:11449/223597Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:51:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
title |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
spellingShingle |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial Stein, Angelica Miki |
title_short |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
title_full |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
title_fullStr |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
title_full_unstemmed |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
title_sort |
Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial |
author |
Stein, Angelica Miki |
author_facet |
Stein, Angelica Miki Coelho, Flávia Gomes de Melo Vital-Silva, Thays Martins [UNESP] Rueda, André Veloso Pereira, Jessica Rodrigues Deslandes, Andréa Camaz Camarini, Rosana Santos Galduróz, Ruth Ferreira |
author_role |
author |
author2 |
Coelho, Flávia Gomes de Melo Vital-Silva, Thays Martins [UNESP] Rueda, André Veloso Pereira, Jessica Rodrigues Deslandes, Andréa Camaz Camarini, Rosana Santos Galduróz, Ruth Ferreira |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
UTFPR: Universidade Tecnológica Federal do Paraná Universidade Federal do Triangulo Mineiro Instituto Federal do Triângulo Mineiro Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Universidade Federal do Rio de Janeiro (UFRJ) Universidade Federal do ABC (UFABC) |
dc.contributor.author.fl_str_mv |
Stein, Angelica Miki Coelho, Flávia Gomes de Melo Vital-Silva, Thays Martins [UNESP] Rueda, André Veloso Pereira, Jessica Rodrigues Deslandes, Andréa Camaz Camarini, Rosana Santos Galduróz, Ruth Ferreira |
description |
Objective: to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer’s Disease (AD) patients. Methods: 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18–Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. Results: After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Conclusion: Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:51:33Z 2022-04-28T19:51:33Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/0361073X.2022.2048586 Experimental Aging Research. 1096-4657 0361-073X http://hdl.handle.net/11449/223597 10.1080/0361073X.2022.2048586 2-s2.0-85126030403 |
url |
http://dx.doi.org/10.1080/0361073X.2022.2048586 http://hdl.handle.net/11449/223597 |
identifier_str_mv |
Experimental Aging Research. 1096-4657 0361-073X 10.1080/0361073X.2022.2048586 2-s2.0-85126030403 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental Aging Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797790423499931648 |